Formula of non-gelatin soft capsule shell

A soft capsule shell, non-gelatin technology, applied in directions such as capsule transportation, can solve problems such as changes in capsule mechanical properties or biological functions, unqualified disintegration time, unstable soft capsules, etc., achieves good moisturizing effect, and is not easy to cross-link. Phenomenon, the effect of excellent dissolution rate

Inactive Publication Date: 2015-02-11
ZHEJIANG CHUNBAO CAPSULES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The sizing material of existing soft capsule shell comprises owing to the shortcoming of using gelatin: (1) cross-linking reaction: gelatin easily takes place cross-linking reaction, causes the instability of soft capsule, as aldehyde, polyphenol, reducing sugar, multiply charged cation, Electrolytes, cationic or anionic polymers, etc., to change the mechanical properties or biological functions of the capsule
[0005] (2) Safety issues: Gelatin is a material derived from animals. The raw material comes from animal skin and bone. Gelatin is an animal protein colloid and contains a small amount of animal fat.
[0006]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] First put 40kg of purified water, 22kg of glycerol and 18kg of sorbitol into the sol tank, close the feeding port, stir, and raise the temperature of the mixed solution to 60°C. The entire sol process ensures that the temperature of the interlayer water is between 60°C and 80°C.

[0056] Then add 50kg of hydroxypropyl modified starch, 10kg of κ-carrageenan, 10kg of ι-carrageenan, 8kg of alginate, and 0.1kg of hypromellose to the sol tank while stirring, control the input speed to prevent agglomeration, and vacuumize the conditions The sol was carried out under the following conditions, and the dissolution time was 1 hour.

[0057] Then, 0.3 kg of pigment is dissolved in hot water and put into the glue solution, and the sunscreen titanium dioxide is formulated into a mother solution and put into the glue solution, and the mixture is stirred evenly.

[0058] Sampling to detect the viscosity and moisture of the glue. When the viscosity value is 18000pa.s and the moisture i...

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PUM

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Abstract

The invention discloses a formula of a non-gelatin soft capsule shell. The soft capsule shell is prepared from the following components in percentage by weight: 25-75 percent of modified starch, 10-30 percent of carrageenan, 10-25 percent of a plasticizer, 40-50 percent of water, 2-12 percent of a thickening agent and the balance of pigment which can be added according to the required color of the soft capsule pill. According to the formula, the main component gelatin of a traditional capsule shell material is replaced by modified starch and carrageenan, so that multiple defects of gelatin can be overcome, the modified starch has the characteristics of film performance, air resistance, adhesion and the like, has high safety performance and good elasticity, and has the dissolving speed superior to that of gelatin; the soft capsule prepared from modified starch and carrageenan has stable property, and cannot easily perform a crosslinking phenomenon; and the soft capsule prepared by using gelatin replacing materials does not have the problem of oxidation crosslinking, and an antioxidant does not need to be added.

Description

【Technical field】 [0001] The invention relates to the technical field of pharmaceutical industrial production, in particular to the technical field of the formulation of a non-gelatin soft capsule shell. 【Background technique】 [0002] Soft capsules refer to dosage forms in which medicinal material extracts, liquid medicines or mixed with suitable excipients are sealed in a hydrophilic soft shell by dropping method or compression method to make spherical, elliptical or other shapes. Soft capsules are suitable for unstable medicinal substances, such as chemical components that are sensitive to light, volatile, unstable and easily oxidized when exposed to heat and humidity, and medicinal substances with unpleasant taste and bad smell. [0003] Soft capsules are a common dosage form for nutritional supplements and western medicines. Soft capsules have become one of the directions for the reform of traditional Chinese medicine formulations. The capsule shell prescription include...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/10A61K47/38
Inventor 潘苏枫
Owner ZHEJIANG CHUNBAO CAPSULES
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