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Carbazochrome Sodium Sulfonate infusion and its preparation method

A technology of sodium carbosulfonate and prescription, which is applied in the field of medicine, can solve the problems of inconvenient clinical use of medical staff and cross-contamination of sodium carbosulfonate, and achieve the effect of quick onset and convenient operation

Inactive Publication Date: 2004-12-29
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sodium carbosulfonate is a new generation of vascular strengthening agent. It is a vascular hemostatic drug with excellent curative effect. It was first jointly developed by Suzhou Sixth Pharmaceutical Factory of Jiangsu Wuzhong Industrial Co., Ltd. and experts from China Medical University. Due to its definite curative effect, And it has a wide range of applications and is widely used in clinical practice. Its domestically marketed dosage forms are sodium carbosulfonate tablets and sodium carbosulfonate for injection. Sodium carbosulfonate for injection often needs to be compatible with normal saline or glucose solution in clinical applications. Intravenous infusion (Li Lianhua et al. Observation of curative effect of sodium carbosulfonate. Chinese Clinical Medicine 2002 Volume 3, No. 24, P39), brings inconvenience to the clinical use of medical staff, and also makes injection of sodium carbosulfonate in Easy to cause cross-contamination during compatible use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: sodium carboxysulfonate infusion, the components are as follows (all by weight):

[0023] Sodium carboxysulfonate 0.059%

[0024] Sodium metabisulfite 0.005%

[0025] Sodium Chloride 0.892%

[0026] Water for injection 99.044%

[0027] The preparation method is as follows:

[0028] (1) The infusion bottle, rubber stopper, and polyester film shall be treated according to the conventional requirements of injections and used for future use.

[0029] (2) Preparation of medicinal liquid:

[0030] a. Weigh 900g of sodium chloride in the solution tank, add 50000g of water for injection, and stir to dissolve. Add 20 g of activated carbon for needles, heat and stir the carbon for adsorption for 30 minutes, filter and decarbonize with a titanium filter rod, add water for injection to the full amount, and stir well.

[0031] b. Weigh 60g of sodium carboxysulfonate and 5g of sodium metabisulfite in a liquid dispensing tank, add 80000g of sodium chloride solution...

Embodiment 2

[0037] Embodiment 2: sodium carboxysulfonate infusion, the components are as follows (all are weight):

[0038] Sodium carboxysulfonate 0.426%

[0039] Glycine 3.551%

[0040] Glucose 25%

[0041] Water for injection 71.023%

[0042] The preparation method is the same as in Example 1.

Embodiment 3

[0043] Embodiment 3: sodium carboxysulfonate infusion, the components are as follows (all by weight):

[0044] Sodium carboxylate 0.12%

[0045] Potassium chloride 0.89%

[0046] Water for injection 98.99%

[0047] The preparation method is the same as in Example 1.

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PUM

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Abstract

The present invention belongs to the field of medicine technology. The Carbazochrome liquid contains Carbazochrome 0.002-0.5 wt%, antioxidant 0-10 wt%, osmotic pressure regulator 0.8-75 wt%, and injection water 20-99.1 wt%. The preparation process of the Carbazochrome liquid includes dissolving osmotic pressure regulator with partial injection water in a compounding tank; adding injection level active carbon through heating and stirring for adsorption for 30 min; filtering and decarbonizing with titanium rod and adding rest injection water to obtain the solution I; dissolving Carbazochrome and antioxidant in solution I, adding injection level active carbon for adsorption for 30 min, filtering and decarbonizing with titanium rod, regulating pH value, fine filtering, detecting, packing in bottle, disinfecting and other steps. The medicine is used in intravenous transfusion for treating various hemorrhage diseases.

Description

(1) Technical field [0001] The invention relates to a sodium carboxysulfonate infusion solution and a preparation method thereof, belonging to the technical field of medicine. (2) Background technology [0002] Sodium carboxylate is a new generation of vascular enhancer and a vascular hemostatic drug with excellent curative effect. It was firstly developed by Jiangsu Wuzhong Industrial Co., Ltd. Suzhou No. 6 Pharmaceutical Factory and experts from China Medical University. And it has a wide range of applications and is widely used in clinical practice. Its domestically marketed dosage forms are sodium carboxylate sulfonate tablets and sodium carboxylate sulfonate for injection. Sodium carboxylate sulfonate for injection often needs to be compatible with normal saline or glucose solution in clinical applications. Intravenous drip (Li Lianhua et al. Observation on the efficacy of sodium carboxylate sulfonate. Zhonghua Clinical Medicine, 2002, Vol. 3, No. 24, P39), which brough...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/404A61P7/04
Inventor 肖广常张颖
Owner 肖广常
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