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Nano-drug carrier particles capable of controlling drug release and preparation method thereof

A nano-drug carrier and nano-particle technology, which can be used in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of reducing the dose of tumor site, tissue cell damage, drug leakage, etc., and achieves increased drug release rate, repeatable High sex, the effect of increasing the dose

Active Publication Date: 2016-08-31
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the gold nanocage has a good hollow structure, a large number of drug molecules can be loaded inside it. However, the drug loaded only by physical adsorption will cause serious drug leakage before entering the diseased tissue cells, thus affecting normal tissue cells. cause some damages
On the one hand, this reduces the dosage of the tumor site, and on the other hand, it also produces relatively large toxic and side effects on normal physiological tissues.

Method used

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  • Nano-drug carrier particles capable of controlling drug release and preparation method thereof
  • Nano-drug carrier particles capable of controlling drug release and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A gold nanocage is used as a drug carrier, and a liposome with pH-sensitive properties is wrapped on its outer layer, and the cell-targeting material transferrin is connected to the outer liposome. Liposome acts as a gate switch, and the schematic diagram of the carrier particle structure is shown in figure 1 .

[0044] 1). Preparation of silver cube nanoparticles: Take 5mL of ethylene glycol and place it in a 50mL round bottom flask, and add clean magnetic particles. Place the round-bottomed flask into an oil bath preheated to 150°C, adjust the magnetic sub-rotational speed to 260-350rpm, and heat for more than half an hour to ensure that the internal temperature reaches 150°C. Then 0.06 mL of 3 mM NaSH in ethylene glycol was added. After 2 minutes, inject 0.5mL of 3mM HCl (2.5μL of 38% concentrated hydrochloric acid is added to 10.3mL of ethylene glycol to prepare a 3mM HCl ethylene glycol solution), and then immediately add 1.25mL of 20mg / mL PVP (molecular weight 5...

Embodiment 2

[0049] A gold nanocage is used as a drug carrier, and a liposome with pH-sensitive properties is wrapped on its outer layer, and the cell-targeting material transferrin is connected to the outer liposome. Liposome is used as a gate switch, and nano drug carrier particles are prepared with doxorubicin (DOX) as drug molecule.

[0050] 1). Preparation of silver cube nanoparticles: Take 2mL of ethylene glycol and put it in a 50mL round bottom flask, and add clean magnetic particles. Put the round-bottomed flask into an oil bath preheated to 140°C, adjust the rotation speed of the magnet to 260-350rpm, and heat for more than half an hour to ensure that the internal temperature reaches 140°C. Then 0.03 mL of 3 mM NaSH in ethylene glycol was added. After 2 minutes, inject 0.2mL of 3mM HCl (2.5μL of 38% concentrated hydrochloric acid is added to 10.3mL of ethylene glycol to prepare a 3mM HCl ethylene glycol solution), and then immediately add 1mL of 20mg / mL PVP (molecular weight 5800...

Embodiment 3

[0056] A gold nanocage is used as a drug carrier, and a liposome with pH-sensitive properties is wrapped on its outer layer, and the cell-targeting material transferrin is connected to the outer liposome. Liposome is used as a gate switch, and nano drug carrier particles are prepared with doxorubicin (DOX) as drug molecule.

[0057] 1). Preparation of silver cube nanoparticles: Take 8mL of ethylene glycol and place it in a 50mL round bottom flask, and add clean magnetic particles. Put the round-bottomed flask into an oil bath preheated to 160°C, adjust the magnetic sub-rotational speed to 260-350rpm, and heat for more than half an hour to ensure that its internal temperature reaches 160°C. Then 0.09 mL of 3 mM NaSH in ethylene glycol was added. After 2 minutes, inject 1.5mL of 3mM HCl (2.5μL of 38% concentrated hydrochloric acid is added to 10.3mL of ethylene glycol to prepare a 3mM HCl ethylene glycol solution), and then immediately add 1.5mL of 20mg / mL PVP (molecular weight...

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Abstract

The invention discloses nano-drug carrier particles capable of controlling drug release. The particles have a core-shell structure, wherein a gold nano-cage (1) which is provided with a mesoporous surface and has a hollow structure is arranged in the innermost layer; a polymer PAH layer (2) carrying positive electricity is used for modifying the surface of the gold nano-cage (1); a pH sensitive lipid layer (3) is arranged on the outer surface coating layer of the polymer PAH layer (2). Under pH and light external excitation trigger, gating is switched from a 'closed' state to an 'open' state, and drug molecules are released. The carrier particles can be used for effectively improving the efficiency of cancer chemotherapy.

Description

technical field [0001] The invention relates to a nano drug carrier particle with controllable drug release and a preparation method thereof, belonging to the field of nano material preparation. Background technique [0002] At present, how to improve the efficiency of cancer chemotherapy and reduce its side effects is an urgent problem to be solved. Therefore, in recent years, the use of nanocapsules as antitumor drug carriers is becoming one of the focuses of medical research. As the specificity of existing anti-tumor drugs is generally not high, how to deliver drugs to cancer cells without damaging normal cells has become one of the key issues in current cancer drug research. [0003] Gold nanocages, as a new type of metal nanoparticles with hollow, surface mesoporous structure and plasmonic properties, have been widely used in the research of nano drug carriers. The good light scattering and absorption ability of this kind of nanoparticle in the near-infrared region an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K9/127A61K47/24A61K47/42A61K47/02A61K31/704A61P35/00
CPCA61K9/0002A61K9/127A61K9/5115A61K9/5192A61K31/704A61K47/24A61K47/42
Inventor 王著元房杰朱丹崔一平
Owner SOUTHEAST UNIV
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