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This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.