Temperature-responsive three-dimensional ordered macroporous controlled-release material

A three-dimensional ordered, temperature-responsive technology, which is applied to medical formulations with non-active ingredients, immobilized on/in organic carriers, pharmaceutical formulations, etc. Low problems, to achieve the effect of good controllable release, high graft density, good threshold flow effect
CN102120854BInactive Publication Date: 2012-08-29HEBEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEBEI UNIV OF TECH
Publication Date
2012-08-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a temperature-responsive three-dimensional ordered macroporous controlled-release material. The apertures of a macropore and a communicating window of the controlled-release material are uniform, wherein the aperture of the macropore is 100-1000nm, the communicating window has a size of 40-120nm and the pore volume is 1.3-2.8cm<3> / g; and a substrate of the controlled-release material is monodisperse three-dimensional ordered macroporous crosslinked polystyrene with mutually communicated windows, a polymer chain segment with temperature responsiveness is introduced onto the substrate through an atom transfer radical activity-controlled graft polymerization method, and the on-off control of the communicating window between macropores is realized by utilizing the extending-curling action of the temperature-responsive polymer chain segment under different temperatures: a macroporous chain gradually shrinks along with the temperature rise, the pore window graduallyopens, and furthermore, the controlled-release action on filled and packaged substances is achieved. The temperature-responsive three-dimensional ordered macroporous controlled-release material has extensive application values in the fields of controlled-release of biomedicines, drug controlled-release systems, controlled release-embedding of active enzyme and catalysts, and the like.
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Description

technical field

[0001] The solution of the invention relates to polymer materials, in particular to a temperature-responsive three-dimensional ordered macropore controlled release material. technical background

[0002] At present, it is a research hotspot in the field of polymer science to use organic polymers as the carrier or medium of active preparations to make sustained-release agents. The controllable release of active preparations has been widely used in the fields of medicine, pesticides, and bioengineering. Extensive research and application (Yang Q, Wang S C, Fan P W, et al. pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery. Chem. Mater., 2005, 17: 5999-6003) . Controlled release means that the active agent in the system can be released into the surrounding environment at a predetermined rate, so that the concentration of the active agent can be maintained within a predetermined range in a certa...

Claims

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