Ph-responsive three-dimensional ordered macroporous controlled-release material
A three-dimensional orderly, controlled release technology, applied in non-active ingredients medical preparations, immobilized on/in organic carriers, pharmaceutical formulations, etc., can solve the problems of capsules that are not easy to overcome the burst release effect, low pore volume, etc. , to achieve the effect of wide application value, good controllable release and high graft density
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[0027] Example 1
[0028] Preparation of responsive 3DOM CLPS-g-PAA materials obtained by hydrolysis of 3DOM CLPS materials with an average pore size of 800 nm grafted on poly(tert-butyl acrylate) segments.
[0029] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm
[0030] At room temperature, in a three-necked flask, sequentially add 11 g of ammonia water with a concentration of 25% by mass, 70 g of absolute ethanol, 6.2 g of distilled water, and 3 g of ethyl orthosilicate. Stir until the mixed solution is a homogeneous and stable suspension, add the same amount of ammonia water, absolute ethanol, distilled water and ethyl orthosilicate in the same mass ratio, repeat 3 times, and pour the obtained suspension into a beaker, At room temperature, the solvent is naturally volatilized completely, and the silica colloidal crystal template is obtained, which is placed in a sweet pot, sintered at 400 ° C in a horse boiler for 5 hours, and then ...
Example Embodiment
[0038] Example 2
[0039] Preparation of pH-responsive 3DOM CLPS-g-PMAA materials obtained by hydrolysis of poly(n-butyl methacrylate) segments grafted on 3DOM CLPS materials with an average pore size of 800 nm
[0040] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm
[0041] The steps of the preparation method of the colloidal crystal template with an average particle size of 1100 nm are the same as those in Example 1(1).
[0042] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 800 nm:
[0043] The preparation method of the three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 800nm The other steps are the same as those in Example 1 (2), except that the volume of 6ml (5.5g) of styrene monomer and 1ml (0.9g) of styrene monomer are adjusted. Vinylbenzene crosslinking agent, 0.03g azobisisobutyronitrile initiator, soak...
Example Embodiment
[0049] Example 3
[0050] Preparation of pH-responsive 3DOM CLPS-g-P4VP materials obtained by grafting poly(4-vinylpyridine) segments to 3DOM CLPS materials with an average pore size of 500 nm.
[0051] (1) Preparation of colloidal crystal templates with an average particle size of 660 nm
[0052] The other steps of the preparation method of the colloidal crystal template with an average particle size of 660 nm are the same as those in Example 1 (1), except that the addition of 14.3 g of ammonia, 91 g of absolute ethanol, 8.06 g of distilled water, 3.9 g ethyl orthosilicate, repeated twice to obtain a colloidal crystal template with an average particle diameter of 660 nm.
[0053] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 500 nm:
[0054] The preparation method of the three-dimensional ordered macroporous cross-linked polystyrene material with an average pore diameter of 500nm The other steps are t...
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