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Ph-responsive three-dimensional ordered macroporous controlled-release material

A three-dimensional orderly, controlled release technology, applied in non-active ingredients medical preparations, immobilized on/in organic carriers, pharmaceutical formulations, etc., can solve the problems of capsules that are not easy to overcome the burst release effect, low pore volume, etc. , to achieve the effect of wide application value, good controllable release and high graft density

Inactive Publication Date: 2011-07-13
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: in view of the low pore volume of the current pH-sensitive mesoporous materials, and the insurmountable burst release effect of the pH-sensitive capsules, the present invention provides a brand-new three-dimensional ordered large-scale The pH value response control release material of the pore material has the characteristics of high pore capacity and slow release

Method used

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  • Ph-responsive three-dimensional ordered macroporous controlled-release material
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  • Ph-responsive three-dimensional ordered macroporous controlled-release material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of responsive 3DOM CLPS-g-PAA material obtained after hydrolysis of 3DOM CLPS material with an average pore size of 800nm ​​grafted with poly(tert-butyl acrylate) segments.

[0029] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm

[0030] At room temperature, in a three-necked flask, 11 g of ammonia water with a concentration of 25% by mass, 70 g of absolute ethanol, 6.2 g of distilled water, and 3 g of ethyl orthosilicate were successively added. Stir until the mixed solution becomes a uniform and stable suspension, add an equal amount of ammonia water, absolute ethanol, distilled water and ethyl orthosilicate in the same mass ratio, repeat 3 times, pour the resulting suspension into a beaker, Stand still at room temperature to allow the solvent to volatilize completely to obtain a silica colloidal crystal template, which is placed in a sweet pot, sintered at 400°C in a horse-boiling furnace for 5 hours, and then slow...

Embodiment 2

[0039] Preparation of pH-responsive 3DOM CLPS-g-PMAA material obtained by grafting poly(n-butyl methacrylate) segments with an average pore size of 800 nm after hydrolysis

[0040] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm

[0041] The preparation method steps of the colloidal crystal template with an average particle diameter of 1100 nm are the same as in Example 1 (1).

[0042] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 800nm:

[0043] Average pore diameter is that the preparation method other steps of 800nm ​​three-dimensional ordered macroporous cross-linked polystyrene material are the same as embodiment 1 (2), what adjust is that adding volume is 6ml (5.5g) styrene monomer, 1ml (0.9g) di Vinylbenzene crosslinking agent, 0.03g azobisisobutyronitrile initiator, soak for 1.5 hours, polymerize at 80°C for 32 hours, peel off the polystyrene on the surfac...

Embodiment 3

[0050] Preparation of pH-responsive 3DOM CLPS-g-P4VP material obtained by grafting poly(4-vinylpyridine) segments on 3DOM CLPS material with an average pore size of 500 nm.

[0051] (1) Preparation of colloidal crystal templates with an average particle size of 660nm

[0052] The other steps of the preparation method of the colloidal crystal template with an average particle diameter of 660nm are the same as in Example 1 (1), and the adjustments are to add 14.3g of ammonia water, 91g of absolute ethanol, 8.06g of distilled water, and 3.9g of distilled water with a concentration of 25%. g tetraethyl orthosilicate, repeated twice to obtain a colloidal crystal template with an average particle diameter of 660 nm.

[0053] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 500nm:

[0054] The average pore diameter is 500nm three-dimensional ordered macroporous cross-linked polystyrene material. The other steps o...

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Abstract

The invention relates to a pH-responsive three-dimensional ordered macroporous controlled-release material. The sizes of macropores and communicating windows of the pH-responsive three-dimensional ordered macroporous controlled-release material are uniform, the sizes of the macropores are 100-1000nm, the sizes of the communicating windows are 40-120nm, and the pore volume is 1.3-2.8 cm<3> / g; the substrate is monodisperse three-dimensional ordered macroporous crosslinked polystyrene with windows which are mutually communicated, and a pH-responsive polymer chain section is introduced into the substrate by an atom transfer free-radical activity-controllable graft polymerization method; and the uncurling-curling action of the pH-responsive polymer chain section under different pH values is utilized to control the opening and closing of the communicating windows among the macropores: as the pH value increases, macromolecule chains gradually uncurl, and the pore windows are gradually closed, thereby realizing the controllable release of the contained filler. The pH-responsive three-dimensional ordered macroporous controlled-release material has wide application values in the controlled-release fields of biomedicine, medicine controlled-release systems, organized enzymes, slow release-embedding of catalysts, and the like.

Description

technical field [0001] The scheme of the present invention relates to polymer materials, in particular to a pH value responsive three-dimensional ordered macropore controlled release material. technical background [0002] Controlled release means that the active agent in the system can be released into the surrounding environment at a predetermined rate, so that the concentration of the active agent can be maintained within a predetermined range in a certain period of time and in a specific area (Reineccius G A. Carbonhydrates for Flavor Encapulation. Food Technology, 1991, 45(3): 144-149). To obtain the ideal release behavior, the material used as the carrier is required to have appropriate physical and chemical properties, be able to produce a certain response to the environment, and have biocompatibility, etc. At present, it is a research hotspot in the field of polymer science to use organic polymers as the carrier or medium of active preparations to make sustained-rel...

Claims

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Application Information

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IPC IPC(8): C08L25/06C08F212/08C08F212/36C08J9/42C08J9/36C08J9/26A61K47/32C12N11/08
Inventor 张旭张海群王小梅王青青刘盘阁
Owner HEBEI UNIV OF TECH
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