Temperature-responsive three-dimensional ordered macroporous controlled-release material

A three-dimensional ordered, temperature-responsive technology, which is applied to medical formulations with non-active ingredients, immobilized on/in organic carriers, pharmaceutical formulations, etc. effect and other problems, to achieve the effects of high graft density, good controllable release, and good threshold flow effect.

Inactive Publication Date: 2011-07-13
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: in view of the deficiencies in the current technology due to the low pore volume of mesoporous materials and the burst release effect that is difficult to overcome in capsules, the present invention provides a new three-dimensional ordered macroporous material. Temperature-responsive controlled release material with high pore capacity and sustained release

Method used

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  • Temperature-responsive three-dimensional ordered macroporous controlled-release material
  • Temperature-responsive three-dimensional ordered macroporous controlled-release material
  • Temperature-responsive three-dimensional ordered macroporous controlled-release material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of responsive 3DOM CLPS-g-PNIPAAm material obtained by grafting poly-segments on 3DOM CLPS material with an average pore size of 500nm.

[0025] (1) Preparation of colloidal crystal templates with an average particle size of 660nm

[0026] At room temperature, 11 g of ammonia water with a concentration of 25% by mass, 70 g of absolute ethanol, 6.2 g of distilled water, and 3 g of ethyl orthosilicate were successively added into a three-necked flask. Stir until the mixed solution is a uniform and stable suspension, add an equal amount of ammonia water, absolute ethanol, distilled water and ethyl orthosilicate in the same mass ratio, repeat twice, pour the obtained suspension into a beaker, Stand still at room temperature to allow the solvent to volatilize completely to obtain a silica colloidal crystal template, which is placed in a sweet pot, sintered at 400°C in a horse-boiling furnace for 5 hours, and then slowly cooled to room temperature to obtain a coll...

Embodiment 2

[0034] Preparation of temperature-responsive 3DOM CLPS-g-PDMAA material obtained by grafting poly N, N-dimethylacrylamide segments on 3DOM CLPS material with an average pore size of 800 nm

[0035] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm

[0036] The other steps of the preparation method of the colloidal crystal template with an average particle diameter of 1100nm are the same as in Example 1 (1), and the change is that the number of repetitions is 3 times to obtain a colloidal crystal template with an average particle diameter of 1100nm silica microspheres adhered to each other ;

[0037] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 800nm:

[0038] Average pore diameter is that the preparation method other steps of 800nm ​​three-dimensional ordered macroporous cross-linked polystyrene material are the same as embodiment 1 (2), what adjust is that adding ...

Embodiment 3

[0044] Preparation of responsive 3DOM CLPS-g-PNIPAAm material obtained by grafting poly-segments on 3DOM CLPS material with an average pore size of 800nm.

[0045] (1) Preparation of colloidal crystal templates with an average particle size of 1100 nm

[0046] The preparation method steps of the colloidal crystal template with an average particle diameter of 1100 nm are the same as in Example 2 (1).

[0047] (2) Preparation of three-dimensional ordered macroporous cross-linked polystyrene material with an average pore size of 800nm:

[0048] The steps of the preparation method of the three-dimensionally ordered macroporous cross-linked polystyrene material with an average pore diameter of 800 nm are the same as in Example 2 (2).

[0049] (3) Grafting of temperature-responsive polymer segments

[0050] The chlorine atom initiator is anchored on the pore wall surface of the three-dimensional ordered macroporous cross-linked polystyrene material through chloromethylation reacti...

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Abstract

The invention relates to a temperature-responsive three-dimensional ordered macroporous controlled-release material. The apertures of a macropore and a communicating window of the controlled-release material are uniform, wherein the aperture of the macropore is 100-1000nm, the communicating window has a size of 40-120nm and the pore volume is 1.3-2.8cm<3> / g; and a substrate of the controlled-release material is monodisperse three-dimensional ordered macroporous crosslinked polystyrene with mutually communicated windows, a polymer chain segment with temperature responsiveness is introduced onto the substrate through an atom transfer radical activity-controlled graft polymerization method, and the on-off control of the communicating window between macropores is realized by utilizing the extending-curling action of the temperature-responsive polymer chain segment under different temperatures: a macroporous chain gradually shrinks along with the temperature rise, the pore window gradually opens, and furthermore, the controlled-release action on filled and packaged substances is achieved. The temperature-responsive three-dimensional ordered macroporous controlled-release material has extensive application values in the fields of controlled-release of biomedicines, drug controlled-release systems, controlled release-embedding of active enzyme and catalysts, and the like.

Description

technical field [0001] The solution of the invention relates to polymer materials, in particular to a temperature-responsive three-dimensional ordered macropore controlled release material. technical background [0002] At present, it is a research hotspot in the field of polymer science to use organic polymers as the carrier or medium of active preparations to make sustained-release agents. The controllable release of active preparations has been widely used in the fields of medicine, pesticides, and bioengineering. Extensive research and application (Yang Q, Wang S C, Fan P W, et al.pH- Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte fo [0003] Ishika et al. (Ishika L, Wang X J, Paul W B. Temperature-Controlled Flow Switching in Nanocapillary Array Membranes Mediated by Poly(N-isopropylacrylamide) Polymer Brushes Grafted by Atom Transfer Radical Polymerization. Langmuir 2007, 23: 305-311) in Tu The surface of porous polyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L25/06C08F212/08C08F212/36C08J9/42C08J9/36C08J9/26A61K47/32C12N11/08
Inventor 张旭王小梅张海群王青青刘盘阁
Owner HEBEI UNIV OF TECH
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