Sphingomonas sp. DS-28 and its probiotics in the treatment of endometritis

By using Sphingomonas DS-28 isolated from the uterus of healthy mice and its postbiotic preparation, the colonization and niche adaptation problems of probiotics in the treatment of endometritis were solved, achieving effective treatment and tissue repair for endometritis.

CN121950642BActive Publication Date: 2026-08-04JILIN AGRICULTURAL UNIV
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Patent Information

Application Number
CN202610434557.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-04-03
Publication Date
2026-08-04
Estimated Expiration
2046-04-03

AI Technical Summary

Technical Problem

Currently, probiotics lack colonization ability and niche adaptability in the treatment of endometritis, resulting in limited treatment effects, and the use of antibiotics poses safety and drug resistance issues.

Method used

We provide Sphingomonas DS-28 isolated from the uterus of healthy mice and its postbiotic preparation. Animal experiments were conducted to verify its efficacy in treating Escherichia coli-induced endometritis, which significantly alleviated inflammation and improved uterine tissue damage.

Benefits of technology

Sphingomonas DS-28 significantly reduces the expression of inflammatory factors in uterine tissue, alleviates pathological damage, and has stronger anti-inflammatory and tissue repair capabilities, providing a new option for non-live bacterial preparations.

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Abstract

This invention provides the application of a uterine-derived Sphingomonas DS-28 strain and its metabolites in the treatment of endometritis, relating to the field of microbial technology. The Sphingomonas DS-28 strain provided by this invention possesses uterine colonization ability, good niche adaptability, and significant efficacy in treating Escherichia coli-induced endometritis. Animal experiments show that the preparation of this strain can effectively alleviate uterine redness and swelling, reduce pathological damage, and significantly reduce [the condition / progression]. TNF-alpha , IL-6 , IL-8 It inhibits gene expression and suppresses the NF-κB signaling pathway, exhibiting superior anti-inflammatory and tissue repair effects compared to other Sphingomonas strains C3-25.1, C3-41.1, and C3-42.1. Furthermore, the metabiotic preparation of this strain can also alleviate Escherichia coli-induced endometritis in mice, improve uterine redness and swelling, and reduce pathological damage.
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