Amlodipine- and erbesartan-containing compound preparation for treating hypertension

A technology of amlodipine and compound preparations, which is applied in the field of compound preparations containing amlodipine and irbesartan for the treatment of hypertension, and can solve the problems of non-optimized proportioning, poor patient compliance, and low blood pressure control rate. Achieve the effects of reducing adverse reactions, quick results, and high blood pressure compliance rate

Inactive Publication Date: 2011-02-09
邬林祥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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  • Amlodipine- and erbesartan-containing compound preparation for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0010] Embodiment 1-4 list is as follows:

[0011] In the embodiment, the conventional method in the pharmaceutical industry is used, and the formula in the following table is prepared into tablets, and the pharmaceutically acceptable carrier-adjuvant used for making the tablet is a conventional adjuvant in the art. Wherein the proportioning of its main components is as follows:

[0012]

[0013] Simultaneously, use conventional method in the pharmaceutical industry in the embodiment, can also be prepared into capsule, soft capsule, granule, powder, sustained and controlled release agent or injection dosage form, pharmaceutically acceptable carrier-the auxiliary material used is the art of this dosage form conventional excipients.

Embodiment 5

[0014] Embodiment 5: The curative effect test of the compound preparation of the present invention for treating hypertension:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on hypertension through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 400 clinical cases of hypertensive patients, 140 were 40-50 years old; 140 were 51-60 years old, and 120 were 61-70 years old.

[0018] 2. Diagnostic criteria: According to the "Guidelines for the Prevention and Treatment of Hypertension in China", hypertension is defined as: systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg without taking antihypertensive drugs.

[0019] 3. Therapeutic method: 400 hypertensive patients are randomly divided into 4 groups, and each group adopts the compound preparation medicine obtained in Examples 1-4 of the present invention respectively to make tablets and take it ...

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Abstract

The invention relates to an amlodipine- and erbesartan-containing compound preparation for treating hypertension, which comprises the following components: amlodipine or pharmaceutically acceptable salts of amlodipine, hydrochlorothiazide, and erbesartan or pharmaceutically acceptable salts of erbesartan which serve as main components, and a medicinal carrier, wherein in each preparation unit, the amlodipine or the pharmaceutically acceptable salts of amlodipine is 2.5 to 10.0mg based on the amlodipine, the erbesartan or pharmaceutically acceptable salts of erbesartan is 27.5 to 300.0mg based on the erbesartan, and the hydrochlorothiazide is 6.25 to 25.0mg. The compound preparation has the advantages that: through medicament combination to give full play to complementary action mechanisms of medicaments, the treatment effect is enhanced, the blood pressure quickly meets the standard, the qualification rate of the blood pressure is 80 percent, untoward effect related to dose increase of a certain medicament is reduced, and the longer action time is kept. The compound preparation has the characteristics of quick response, high qualification rate of blood pressure, small side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing amlodipine and irbesartan for treating hypertension, belonging to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARBs), etc., but it is difficult to achieve the standard for a single drug treatment of hypertension in the sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/12A61K31/4184A61K31/549A61K31/4422
Inventor 邬林祥邬林云
Owner 邬林祥
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