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Dispersible tablet for treating hypertension

A technology of dispersible tablets and hydrochlorothiazide, which is applied in the directions of organic active ingredients, cardiovascular system diseases, and medical preparations containing active ingredients, etc., can solve the problems that there is no scientific basis for the development of compound irbesartan dispersible tablet forms.

Active Publication Date: 2006-02-15
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no one has provided a scientific basis for the development of compound irbesartan dispersible tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: prescription (calculated in single tablet)

[0035] Component Content (mg / tablet)

[0036]Irbesartan 300mg

[0037] Hydrochlorothiazide 12.5mg

[0038] Microcrystalline Cellulose 150mg

[0039] Mannitol 100mg

[0040] Sodium Carboxymethyl Starch 40mg

[0041] Low-substituted hydroxypropyl cellulose 10mg

[0042] Micronized silica gel 10mg

[0043] Talc powder 5mg

[0044] Stevia 5mg

[0045] 3% hypromellose in 90% ethanol solution

[0046] Total tablet weight 632.5mg

[0047] Process:

[0048] Get the raw materials of irbesartan and hydrochlorothiazide, pulverize them, pass through a 200-mesh sieve, and set aside.

[0049] According to the prescription amount, weigh irbesartan, hydrochlorothiazide, microcrystalline cellulose, mannitol, stevioside and carboxymethyl starch sodium, mix them evenly through a 100 mesh sieve, pour into the adhesive soft material, pass through a 40 mesh sieve to granulate , dried at 55°C, granulated with 40 mesh, ...

Embodiment 2

[0050] Embodiment 2: prescription (calculated in single tablet)

[0051] Component Content (mg / tablet)

[0052] Irbesartan 75mg

[0053] Hydrochlorothiazide 25mg

[0054] Calcium Sulfate 50mg

[0055] Microcrystalline Cellulose 100mg

[0056] Low-substituted hydroxypropyl cellulose 30mg

[0057] Micronized silica gel 5mg

[0058] Talc powder 5mg

[0059] Aspartame 5mg

[0060] 2% hypromellose in 75% ethanol solution

[0061] Total tablet weight 295mg

[0062] Process:

[0063] According to the prescription amount, weigh irbesartan, hydrochlorothiazide, calcium sulfate, microcrystalline cellulose, aspartame and 3 / 4 of the prescription amount of low-substituted hydroxypropyl cellulose, pass through a 100-mesh sieve and mix evenly, pour into viscous Mixture soft material, pass through a 20 mesh sieve, granulate, dry at 50°C, granulate at 20 mesh, add micropowder silica gel, talcum powder and remaining low-substituted hydroxypropyl cellulose that have passed thro...

Embodiment 3

[0064] Embodiment 3: Prescription (calculated in single tablet)

[0065] Component Content (mg / tablet)

[0066] Irbesartan 300mg

[0067] Hydrochlorothiazide 25mg

[0068] Mannitol 75mg

[0069] Calcium Sulfate 75mg

[0070] Carboxymethyl Starch Sodium 50mg

[0071] Low-substituted hydroxypropyl cellulose 10mg

[0072] Sodium Lauryl Sulfate 15mg

[0073] Micronized silica gel 10mg

[0074] Talc powder 10mg

[0075] Protein sugar 20mg

[0076] 5% hypromellose in 95% ethanol solution

[0077] Total tablet weight 590mg

[0078] Process:

[0079] Get the raw materials of irbesartan and hydrochlorothiazide, pulverize them, pass through a 180-mesh sieve, and set aside.

[0080] According to the prescription amount, weigh irbesartan, hydrochlorothiazide, mannitol, calcium sulfate, sodium starch glycolate, sodium lauryl sulfate, protein sugar, pass through a 100-mesh sieve and mix evenly, pour into the soft material made of adhesive, Pass through a 18-mesh sieve t...

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PUM

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Abstract

The invention relates to a medicinal oral preparation containing Irbesartan and Hydrochlorothiazide, more specifically the dispersible tablets for enhancing the beneficial effects of Irbesartan and Hydrochlorothiazide.

Description

technical field [0001] The present invention relates to a pharmaceutical oral formulation comprising irbesartan and hydrochlorothiazide, in particular to a dispersible tablet form for enhancing the beneficial effects of irbesartan and hydrochlorothiazide. Background technique [0002] Irbesartan is an angiotensin II (Angiotensin II) receptor inhibitor, which can inhibit the transformation of Ang I into Ang II, and can specifically antagonize the angiotensin-converting enzyme 1 receptor (AT1). AT28500 times, by selectively blocking the combination of Ang II and AT1 receptors, inhibiting vasoconstriction and aldosterone release, resulting in antihypertensive effect. Hydrochlorothiazide (hydrochlorothiazide, HCTZ) is a traditional antihypertensive drug and belongs to the middle-effect diuretic. Acts on the distal renal tubule to activate the renin-angiotensin system (RAS). The combined application of the two can make blood pressure more effectively controlled; compared with t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K9/20A61P9/12A61K31/4184
Inventor 姚俊华
Owner 江苏万高药业股份有限公司
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