Irbesartan-containing pharmaceutical composition and preparing process thereof

Abstract

The invention relates to an irbesartan-containing pharmaceutical composition and a preparing process thereof; the pharmaceutical composition comprises the following components: irbesartan, hydrochlorothiazide, lactose, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methyl cellulose, silicon dioxide, magnesium stearate and a coating. Because a solid dispersoid technology is applied in the production manufacturing process, the materials are only subjected to conventional crushing treatment, and great change of the material physical properties are not caused; therefore, selection of a flow aid has no special requirements, and a high-quality and competitive-price precipitated silicon dioxide is selected in the premise of meeting the requirements of the production process.

Description

technical field [0001] The invention relates to a preparation of irbesartan, in particular to a pharmaceutical composition containing irbesartan and a preparation process thereof. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. According to the 2004 survey on nutrition and health status of Chinese residents, the prevalence rate of hypertension among residents aged 18 and over in my country is 18.8%, and it is estimated that the number of patients nationwide exceeds 160 million. Compared with 1991, the prevalence rate increased by 31%, and the number of patients increased by about 70 million people. [0003] In 1998, cerebrovascular disease was the second leading cause of death among urban residents in my country and the first in rural areas. There are more than 1 million deaths every year in the country, and about 5 to 6 million surviving patients, of which more than 75% have disabilities of ...