Felodipine ramipril compound sustained-release preparation and preparation method thereof

A sustained-release preparation, the technology of felodipine, which is applied in the field of felodipine and ramipril compound sustained-release preparations and its preparation, can solve the problem that there is no production, marketing and registration application for felodipine and ramipril compound sustained-release preparations. problems, to achieve the effect of small differences in individual bioavailability, good fluidity, and reduction of drug toxicity and side effects
CN102600451AInactive Publication Date: 2012-07-25广州科的信医药技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广州科的信医药技术有限公司
Publication Date
2012-07-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a compound sustained-release preparation containing felodipine and ramipril and a preparation method of the compound sustained-release preparation, wherein the compound sustained-release preparation is prepared by mixing felodipine sustained-release pellets and ramipril immediate-release pellets according to a specific dose proportion. The felodipine sustained-release pellets can sustainably release for 12 hours, and can be taken once a day, so as to keep the antihypertensive effect for a long time, the ramipril immediate-release pellets can be quickly absorbed so as to achieve the antihypertensive effect and treat the plasma concentration, due to the combination of the two kinds of pellets, the antihypertensive effect can be greatly enhanced, the toxic and side effect of the medicine can be reduced, the administration frequency can be reduced, sustainably stable antihypertensive effect can be achieved in a human body, the patient compliance can be enhanced, the compound sustained-release preparation consists of hundreds and thousands of pellets in uniform particle sizes, so that the damage of individual pellets will not cause burst release of the whole preparation, and compared with the sustained release tablets, the compound sustained-release preparation disclosed by the invention has the advantages of higher safety, lower irritation to gastrointestinal tract, more stable plasma concentration and capability of effectively improving the clinical effect.
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Description

technical field

[0001] The invention relates to the technical field of a compound sustained-release preparation, in particular to a felodipine-ramipril compound sustained-release preparation and a preparation method thereof. It belongs to a compound sustained-release preparation of antihypertensive drugs. Background technique

[0002] Hypertension is one of the most common cardiovascular diseases, and it is also a major risk factor leading to increased morbidity and mortality of congestive heart failure, stroke, coronary heart disease, renal failure, and aortic aneurysm. In recent years, with the continuous improvement of the living standards of the Chinese people and the growth of the elderly population, hypertension is becoming a common disease with a very high prevalence rate and has entered our lives. At present, there is no effective way to cure hypertension in the world. Once the disease is diagnosed, it will be accompanied by lifelong and cause many other related dis...

Claims

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