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Medicine composite for treating and relieving high blood pressure

A composition and technology for hypertension are applied in the field of pharmaceutical compositions for hypertension, and can solve the problems such as the pharmaceutical composition formed by telmisartan and felodipine sustained-release preparations that have not been found yet.

Inactive Publication Date: 2010-04-28
广西方略集团崇左制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] At present, no patent literature or other literature reports on the pharmaceutical composition composed of telmisartan and felodipine sustained-release preparations have been found.

Method used

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  • Medicine composite for treating and relieving high blood pressure
  • Medicine composite for treating and relieving high blood pressure
  • Medicine composite for treating and relieving high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Telmisartan-felodipine double-layer sustained-release tablet (40 / 5mg)

[0037] prescription:

[0038] Felodipine

[0039] Component Dosage

[0040] Felodipine 5.0g

[0041] HPMC-K15M 60.0g

[0042] Lactose 20.0g

[0043] Magnesium Stearate 1.0g

[0044] 5% starch slurry appropriate amount

[0045] Telmisartan layer

[0046] Component Dosage

[0047] Telmisartan 40.0g

[0048] Microcrystalline Cellulose 80.0g

[0049] Lactose 50.0g

[0050] Povidone 5.0g

[0051] Magnesium Stearate 1.5g

[0052] 5% starch slurry appropriate amount

[0053] A total of 1000 pieces were made

[0054] Preparation:

[0055] The felodipine of the prescribed amount is passed through a 100-mesh sieve, and the HPMC-K15M and lactose of the prescribed amount are respectively passed through a 60-mesh sieve. Mix the above raw and auxiliary materials evenly, make soft material with 5% starch slurry, granulate with 18 mesh sieve, dry at 50°C, granulate with 20 mesh sieve, a...

Embodiment 2

[0058] Embodiment 2 Telmisartan and felodipine double-layer sustained-release tablet (40 / 2.5mg)

[0059] prescription:

[0060] Felodipine sustained release layer

[0061] Component Dosage

[0062] Felodipine 2.5g

[0063] HPMC-K15M 40.0g

[0064] Lactose 10.0g

[0065] Magnesium Stearate 1.0g

[0066] 5% starch slurry appropriate amount

[0067] Telmisartan immediate release layer

[0068] Component Dosage

[0069] Telmisartan 40.0g

[0070] Microcrystalline Cellulose 100.0g

[0071] Lactose 40.0g

[0072] Sodium carboxymethyl starch 6.0g

[0073] Magnesium Stearate 2.0g

[0074] 5% starch slurry appropriate amount

[0075] A total of 1000 pieces were made

[0076] Preparation:

[0077] The felodipine of the prescribed amount is passed through a 100-mesh sieve, and the HPMC-K15M and lactose of the prescribed amount are respectively passed through a 60-mesh sieve. Mix the above raw and auxiliary materials evenly, make soft material with 5% starch slurry, granul...

Embodiment 3

[0080] Embodiment 3 telmisartan and felodipine double-layer sustained-release tablet (40 / 10mg)

[0081] prescription:

[0082] Felodipine sustained release layer

[0083] Component Dosage

[0084] Felodipine 10.0g

[0085] HPMC-K100M 50.0g

[0086] Lactose 30.0g

[0087] Magnesium Stearate 1.0g

[0088] 5%HPMC-E 6 Appropriate amount

[0089] Telmisartan immediate release layer

[0090] Component Dosage

[0091] Telmisartan 40.0g

[0092] Microcrystalline Cellulose 100.0g

[0093] Pregelatinized starch 40.0g

[0094] Magnesium Stearate 2.0g

[0095] 5%HPMC-E 6 Appropriate amount

[0096] A total of 1000 pieces were made

[0097] Preparation:

[0098] The felodipine of the prescribed amount is passed through a 100-mesh sieve, and the HPMC-K100M and lactose of the prescribed amount are respectively passed through a 60-mesh sieve. Mix the above raw and auxiliary materials evenly, and use 5% HPMC-E 6 Make soft material, granulate with 18 mesh sieve, dry ...

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PUM

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Abstract

The invention discloses a medicine composite for treating and relieving high blood pressure and a preparation method thereof. The composite comprises 10-320mg of telmisartan and 1-20mg of felodipine slow-release preparation. The composite is used for treating patients with moderate and acute high blood pressure and patients whose blood pressure can not be adequately controlled after the high blood pressure is treated by an angiotensin II receptor antagonist or a calcium antagonist.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof for treating patients with moderate or high blood pressure and hypertension whose blood pressure cannot be fully controlled after treatment with angiotensin II receptor antagonists or calcium antagonists, specifically Pharmaceutical composition and use made with telmisartan and felodipine. Background technique [0002] Telmisartan, a white to pale yellow solid, is an angiotensin II receptor antagonist developed for the treatment of hypertension and other medical indications as disclosed in EP-A-502314. It is a non-peptide molecule, and its chemical name is: 4'-[(1,4'-dimethyl-2'-propyl-[2,6'-bi-1H-benzimidazole]-1'-yl) Methyl]-[1,1'-biphenyl]-2-carboxylic acid, its molecular formula is: C 33 h 30 N 4 o 2 , its molecular weight is: 514.63, and its structural formula is: [0003] [0004] Telmisartan is prepared and supplied in the free acid form. It is chara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/4184A61K9/24A61P9/12
Inventor 杨进明王德武莫国飞
Owner 广西方略集团崇左制药有限公司
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