Felodipine sustained-release tablet and preparation method thereof

Abstract

The invention relates to a felodipine sustained-release tablet and a preparation method thereof. The sustained-release tablet contains an effective amount of felodipine, polyvinylpyrrolidone K30 or polyvinylpyrrolidone K25, wherein the ratio of the polyvinylpyrrolidone K30 or polyvinylpyrrolidone K25 to the felodipine is 3 to 12 : 1, sustained-release materials and the like. The preparation method of the felodipine sustained-release tablet comprises the following steps: adding a solubiliser into an organic good solvent of felodipine for dissolution, and then adding the felodipine for completedissolution of the solubiliser; adding a prepared solution into a adsorbent mixture, and performing sieving and granulating; and then carrying out drying under a normal pressure to obtain sustained-release dry particles containing solubilized felodipine, and then carrying out granulating, tabletting, and coating to obtain a felodipine sustained-release tablet. According to the invention, the felodipine is solubilized, which enables the curative effect to be enhanced. Besides, a traditional hard-soluble medicament sustained-release tablet has complicated preparation process with high energy consumption, and is not easy to produce and uncontrollable in quality; however, the above problems are solved by the preparation method provided in the invention. Therefore, the simple, low-energy, and high-efficient industrialized production is allowed according to the invention.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a felodipine sustained-release tablet and a preparation method thereof. Background technique [0002] Felodipine is a new generation of DHPs calcium antagonist with high selectivity to blood vessels, which lowers blood pressure by reducing peripheral vascular resistance. The half-life of felodipine sustained-release tablets is as long as 25 hours, and it is taken once a day. It is convenient to use and has good patient compliance. It can be used as an effective drug for the long-term treatment of essential hypertension and is suitable for the treatment of all stages of hypertension. [0003] Scientific research has found that simple high blood pressure can cause damage to organs, but blood pressure fluctuations are especially serious. Felodipine ordinary tablets need to be taken 2-3 times a day. Although this preparation can achieve blood pressure lowering However, d...

AI Technical Summary

Problems solved by technology

This method process is more complicated, and the use cost of crospovidone is high

Cross-linked povidone is used as a super disintegrant. This method is effective in preparing fast-dissolving preparations, but the preparation of sustained-release preparations leads to difficulty in controlling the release rate, large amount of sustained-release matrix materials, obvious burst release phenomenon, and difficult to guarantee safety.

[0006] The preparation methods of the above-mentioned prior art are complicated, the process is cumbersome, the energy consumption is high, and industrialized production is very difficult, which has seriously affected the production and application of felodipine sustained-release preparations

There are also some companies that have not solubilized felodipine, but directly prepared sustained-release preparations, resulting in poor curative effect of some felodipine sustained-release preparations, affecting the healing of patients.