Medicinal composition containing felodipine and metoprolol

A kind of technology of felodipine and composition, applied in the field of solid pharmaceutical composition containing felodipine and metoprolol

Inactive Publication Date: 2010-01-13
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To sum up these technologies, different amounts of toxic organic solvents, such as isopropanol, are used in the implementation process.

Method used

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  • Medicinal composition containing felodipine and metoprolol
  • Medicinal composition containing felodipine and metoprolol
  • Medicinal composition containing felodipine and metoprolol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] Preparation:

[0025] Weigh the prescribed amount of felodipine and p-hydroxytert-butylanisole, add a certain amount of ethanol to dissolve, add lactose to mix, then mix with calcium hydrogen phosphate and hypromellose, add 50% alcohol water to make granules , dry, add magnesium stearate and mix well, and set aside; another prescription amount of metoprolol succinate and calcium stearate is crushed together, passed through a 200-mesh sieve, mixed with wax 888, and ethanol with shellac The solution is granulated, dried, added with magnesium stearate and mixed evenly, together with the above-mentioned felodipine granules, it is compressed into tablets by a double-layer tablet press. Coating with 15% Opadry solution, that is.

Embodiment 2

[0027]

[0028] Preparation:

[0029] Weigh the prescribed amount of felodipine and p-hydroxytert-butylanisole, add a certain amount of ethanol to dissolve, add lactose to mix, then mix with calcium hydrogen phosphate and hypromellose, add 50% alcohol water to make granules , dry, add magnesium stearate and mix well, and set aside; another prescription amount of metoprolol succinate and magnesium stearate is weighed and pulverized together, passed through a 80-mesh sieve, mixed with wax 888, and ethanol with shellac The solution is granulated, dried, added with magnesium stearate and mixed evenly, together with the above-mentioned felodipine granules, it is compressed into tablets by a double-layer tablet press. Coating with 15% Opadry solution, that is.

Embodiment 3

[0031]

[0032] Preparation:

[0033] Weigh the prescribed amount of felodipine and p-hydroxytert-butylanisole, add a certain amount of ethanol to dissolve, add lactose to mix, then mix with calcium hydrogen phosphate and hypromellose, add 50% alcohol water to make granules , dried, added magnesium stearate and mixed, and set aside; another prescription amount of metoprolol succinate was crushed with stearyl alcohol, passed through a 65-mesh sieve, mixed with waxy 888, ethyl cellulose, added insecticide The ethanol solution of the gum is granulated, dried, mixed with magnesium stearate, and compressed with the above-mentioned felodipine granules using a double-layer tablet press. Coating with 15% Opadry solution, that is.

[0034] The above-mentioned embodiment 1,2,3 and the compound felodipine metoprolol slow-release tablet of commercially available trade name LOGIMAX are in the phosphate buffer saline buffer of 6.5 respectively in the pH of 1% SDS, according to Chinese P...

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Abstract

The invention discloses a medicinal composition containing felodipine and metoprolol, which contains the felodipine and the metoprolol with a grain diameter D90 of between 10 and 200mu m, wherein the felodipine and the metoprolol are double-layer tablets prepared by dispersing in respective pharmaceutically acceptable carriers respectively in the medicinal composition. The composition can be steadily released, has good stability at the same time, and is used for the hypertension which has poor treatment effect by other medicaments.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension, in particular to a solid pharmaceutical composition containing felodipine and metoprolol. Background technique [0002] Felodipine belongs to dihydropyridines, which can reduce vascular resistance and cardiac load through direct action on vascular smooth muscle, and is widely used in the treatment of cardiovascular diseases. Felodipine has extremely low solubility in water, and becomes an obstacle affecting absorption due to incomplete or slow dissolution in the body, making it a difficult problem for the human body to absorb and utilize it for a long time by preparing its slow and controlled release preparation and controlling its release. Therefore, many applicants use solubilizers to solubilize it and then prepare it into sustained and controlled release preparations, which is relatively common. For example, in the patent CN1189774A, it is prepared into a solid dispersi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/138A61K9/28A61P9/12
Inventor 尚丽霞
Owner BEIJING D VENTUREPHARM TECH DEV
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