Compound apigenin nanoemulsion antihypertensive drug

Abstract

The invention discloses a compound apigenin nanoemulsion antihypertensive drug which comprises the following raw materials in mass percent: 1-15% of apigenin, 5-35% of surfactant, 1-20% of cosurfactant, 1-20% of oil, 0.5-10% of motherwort fruit aqueous extract, 0.5-10% of semen cassiae water extract and the balance of distilled water; and the sum of mass percents of the above raw materials is 100%. The nanoemulsion is small in emulsion droplet, uniform in distribution, low in viscosity and good in liquidity. After apigenin is prepared into a nanoemulsion, blood brain barrier transmission capacity is obviously increased, the bioavailability of a technical material is obviously improved, the half-life period of the drug can be prolonged; and the drug administration times can be reduced; with adoption of the nanoemulsion, the dissolution and infiltration capacity of atenolol can be improved and the stability of apigenin is increased; and the nanoemulsion has obvious synergistic effect compounded with the motherwort fruit and the semen cassiae; and the medicinal cure effect can be more fully played.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antihypertensive drug apigenin, in particular to a compound apigenin nanoemulsion antihypertensive drug. Background technique [0002] The chemical structure of apigenin is 4,5,7-trihydroxyflavone, the three hydroxyl groups at the 4,5,7 positions and the C 2 C 3 The double bond determines its unique pharmacological effects and biological properties. The source of apigenin is Apium graveolens var.dulce leaves; Selaginella tamariscina whole herb; Cupressaceae Sabina chinensis leaves. Zhang et al. found that apigenin had a significant relaxation effect on the contraction of mouse aortic rings caused by high K-induced removal of endothelial cells when the concentration was greater than 1 [IC 50 is (12.0±1.1)μM]. Phenylephrine has a stable contraction effect on isolated aortic rings with or without endothelial cells, and apigenin has a dose-dependent (1-12.5 μM) rela...

AI Technical Summary

Problems solved by technology

Existing antihypertensive drugs such as apigenin suspension in the market, although can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Coupled with the slow action of apigenin itself, the efficacy of apigenin cannot be utilized quickly

Images