Combination antihypertensive wafer

A composition and high blood pressure technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of restricting the freedom of movement of patients, inconvenience, need of water, etc., to avoid the first-pass effect, easy to take, and reduce the dose. Effect

Inactive Publication Date: 2009-07-01
LTS LOHMANN THERAPIE-SYST AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A disadvantage of conventional tablet administration for many patients is that water etc. are usually required in order to swallow the tablet
This limits the patient's freedom of movement and is considered an inconvenience

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] Water-soluble or swellable polymers suitable as base polymers for hydrophilic water-soluble and / or swellable polymer films are polymers in the group comprising: dextran; polysaccharides including starch and starch derivatives such as carboxymethyl cellulose, ethyl cellulose or propyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose (e.g. Walocel), methyl Cellulose, cellulose derivatives of hydroxyethylcellulose and hydroxypropylethylcellulose; polyvinyl alcohol; polyethylene glycol; polyacrylic acid; polyacrylates; polyvinylpyrrolidone; alginate; pectin; gelatin ; alginic acid; collagen; chitosan; arabinogalactan; galactomannan; agar; agarose; carrageenan natural gum; tragacanth; highly dispersed silica; bentonite; and the above Derivatives of hydrophilic polymers; or combinations of two or more of these polymers. Alternatively, the polymer film can be made of polyvinyl alcohol-polyethylene glycol graft copolymer.

[0...

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PUM

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Abstract

The present invention relates to a planar-shaped drug preparation that quickly dissolves or decomposes in an aqueous environment, for the application of active ingredient combinations for the treatment of hypertension, wherein the drug preparations contain at least two active ingredients that are suitable for the treatment of hypertension, and wherein the antihypertensive drug is selected from the group that encompasses beta receptor blockers, alpha receptor blockers, calcium antagonists, ACE inhibitors, AT1 antagonists, centrally acting antihypertensive drugs, direct vasodilators, and diuretics. The present invention also relates to the use of active ingredient combinations according to the invention for the production of an oral drug preparation for the treatment of high blood pressure, to a method for the therapeutic treatment of hypertension, and to a method for the production of a planar-shaped drug preparation.

Description

technical field [0001] The present invention relates to rapidly dissolving or disintegrating tablet dosage forms in an aqueous environment for the administration of an active agent composition for the treatment of hypertension. Background technique [0002] According to the "Hochdruckliga" the ideal blood pressure is 120 / 80 mmHg. In contrast, hypertension is considered to be a pathological increase in arterial pressure to systolic values ​​above 140 mmHg and diastolic values ​​above 90 mmHg. [0003] Recent studies have found that high blood pressure is a widespread disease in countries with a western lifestyle and the cause of high blood pressure values ​​cannot be found in 90% of patients, which is why this high blood pressure is called the cause idiopathic or essential hypertension. Nonetheless, certain risk factors such as genetic predisposition, being overweight, lack of exercise, stress or eating high amounts of salt can contribute to the development of high blood pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/00A61K45/06A61P9/12
CPCA61K9/006A61K45/06A61K31/00A61K9/7007A61P9/12A61K2300/00
Inventor 汉斯来纳·霍夫曼雷托·布兰德利弗兰克·西奥博尔德
Owner LTS LOHMANN THERAPIE-SYST AG
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