47results about How to "Avoid the first pass effect" patented technology

The invention relates to an inhalation spray of antivirus medicines. The inhalation spray comprises the following components in percentage by mass of 0%-30% of antivirus activity agents, 0%-30% of auxiliary agents, 0%-30% of taste masking agents and the balance solvents, wherein the content of the antivirus activity agents and the content of the auxiliary agents are not 0% at the same time. Compared with the prior art, the inhalation spray disclosed by the application has the purpose that during outbreak period of epidemic corona viruses and other viruses, people do not need to occupy medicalresources in short supply and only need to inhale the antivirus medicines into respiratory tracts, medicine administration is accurately targeted, and the objective of preventing virus infection and propagation can be achieved; in addition, through united medication of the antivirus activity agents and the auxiliary agents, besides, various medicines are inhaled into the respiratory tract of a patient, synergistic treatment effects are generated, the viruses are eliminated, and serious respiratory tract and infection and serious pulmonary infection caused by the viruses can be treated; and chloroquine type antivirus medicines and macrocyclic antibiotics are inhaled through spraying for united medication, and the dosage of the medicines can be notably reduced, so that side effects of prolonged QT intervals, Tdp and sudden cardiac death caused by the medicines can be reduced.

The present invention relates to one kind of broad-spectrum cancer treating Chinese medicine capsule and its preparation process. It is prepared with trichosanthes root, edible tulip bulb, zedoary, pinellia tuber, grisaema tuber and other Chinese medicinal materials. It has the functions of nourishing Yin, promoting blood circulation, warming Yang, promoting urination, dredging meridian and dissipating mass. The animal experiment and the clinical application show that the Chinese medicine has obvious curative effect, no negative reaction and no toxic side effect.

The invention relates to a surface coating adopting contraceptive for women, which consists of one or more than one active components such as compound, infiltrating accelerant, and humectant in anti-progestin medicine or progestational hormone medicine and estrogen medicine as well as normal raw materials such as oily component, aqueous component, macromolecule material, surface active agent, bacteriostat, chemical inhibitor and spice and so on. The invention can be made into electuary, emulsion, cream, jellies, spray and liquid cream so as to be used in contraception, urgent contraception, lactation contraception and reproductive health. The contraceptive adopts a method of being coated on the skin or the mucosa surface to reach the aim so as to prevent the first-pass effect and the gastrointestinal tract effect of the oral medicine, thereby reducing the injure to the liver and the kidney, reducing toxic and side effect, providing new preparation, method and route of administration for enlarging the range of the medicine-user, and making the contraception become more simple, convenient, easier and more willing to be accepted.

The invention discloses a lappaconitine transdermal patch and preparation method thereof. The patch comprises a back sheet, a drug storing layer and a protection layer, wherein, the drug storing layer is composed of the raw materials of lappaconitine and pressure sensitive adhesive, or a right amount of transdermal accelerant is added to finally prepare lappaconitine transdermal patch. The lappaconitine transdermal patch of the invention has the advantages of convenient use, high bioavailability and lasting action, avoids first-pass effect of liver as well as damage to gastrointestinal tract, reduces drug toxicity and side effect, improves bioavailability of drug and safety of treatment, and has obvious effect on anti-inflammatory and analgesia.

The invention discloses a traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and a preparation method thereof. According to the method, apithecellobium clypearia extract and a lamiophlomis rotata extract are used as raw materials; poly(lactic-co-glycolic acid) PLGA, vitamin E polyethylene glycol succinate TPGS and poloxamer are used as a drug-loaded matrix. The preparation method comprises the following steps: mixing raw medicinal materials with the drug-loaded matrix to form an oil phase and an oil-in-water phase, performing probe ultrasonic emulsification to obtain a nano-suspension, and adding carbomer, collagen tripeptide, oat beta-glucan and propylene glycol as a gel matrix to obtain traditional Chinese medicine composition nanogel. The prepared traditional Chinese medicine composition nanogel has the particle size of 120 nm-260 nm, has good drug loading capacity, obviously improves the solubility and bioavailabilityof hydrophobic drugs, inhibits bacteria, diminishes inflammation, stops bleeding and relieves pain, and is definite in curative effect.

The invention discloses a traditional Chinese medicine foot bath preparation prepared by utilizing microbial fermentation and a preparation method thereof and belongs to the field of parenteral administration preparations. The preparation method includes: placing brewer's yeast, candida utilis and lactobacillus reuteri in a water solution of ginkgo leaf extract, algae powder, menthol, baking soda, edible salt and glucose at 37-40 DEG C for anaerobic cultivation to obtain microbial fermentation foot bath preparation engineering bacterium liquid. The bacterium liquid is adopted for fermenting compound traditional Chinese medicine. The ginkgo leaf extract has promoting effect on expanding pores and blood vessels and increasing administration speed, menthol has transdermal efficacy and can improve permeability of drug in a plantar dermis layer and a cuticle layer, density of foot bath liquid prepared by baking soda, edible salt and glucose is greater than that of body fluid, so that osmotic pressure of the foot bath liquid is increased. Toxic and harmful substances in the compound traditional Chinese medicine are degraded after fermentation, and absorbing effect of traditional Chinese medicine activity agent is improved by utilizing synergistic effect of beneficial bacteria and active ingredients of the traditional Chinese medicine. The traditional Chinese medicine foot bath preparation is effective in disease dispelling, healthcare and scientific administration.

The invention relates to the cream and the ointment of Letrozole tablet percutaneous administration and the preparation method of the cream and the ointment thereof, and relates to the cream and the ointment of the percutaneous administration and the preparation method of the cream and the ointment thereof. The invention solves the problems that the prior Letrozole tablet oral preparation cannot avoid the first pass effect of liver and the bad reaction is numerous. The cream and the ointment of the percutaneous administration are characterized in that the cream and the ointment of the percutaneous administration comprise raw materials and penetrating agent with the following percentages: 0.01 to 20 percent of Letrozole tablet and 0.1 to 20 percent of percutaneous penetrating agent. The invention has the method that through vitro and a skin penetration test, the Letrozole tablet only with oral preparation is filtered out a formula with good non-steady state/steady state distribution by a skin release curve, and then the cream and the ointment of the percutaneous administration are prepared, so as to lead principal medicine to avoid the liver first pass effect of oral administration to directly reach mammary gland target tissue, and to lead the concentration of target tissue internal medicine to be improved. Compared with the prior preparation at home and at abroad, the invention technically has the advantages that the prepared external preparation can reduce the side effect of Letrozole tablet and improve the curative effect of the Letrozole tablet, thereby the invention has good promotion and application value.

The invention relates to a slow release long-acting rasagiline transdermal patch with high bioavailability and a preparation method thereof. The patch is characterized in that effective amount of rasagiline and a substrate are contained, wherein the concentration of rasagiline is in the range of 0.1 mg/cm2 - 2 mg/cm2, every patch contains 1 mg - 10 mg of rasagiline, and the substrate contains one or more than two kinds of the following substances: acrylic polymers containing no carboxylic group and silicone polymers with silanol groups capped by alkyls. The time of maximum plasma drug concentration of the patch is prolonged to be 5 times or more that of oral tablets, and the bioavailability of the patch is 130 percent or more of that of oral tablets. The patch in the invention can be applied to effectively inhibit monoamine oxidase B (MAOB) for at least 3 days, in addition, the preparation method is simple and suitable for industrial production.

The invention discloses a transdermal drug delivery system for treating infantile diarrhea. The transdermal drug delivery system consists of a substrate layer, a backing layer and a protective film; and the substrate layer comprises the following components in percentage by weight: 0.5 to 55 percent of gallnut extract, 5 to 60 percent of adhesive, 3 to 20 percent of organic solvent, 1 to 20 percent of plasticizer, 2 to 30 percent of thickening agent, and 1 to 10 percent of penetration enhancer. The substrate layer of the traditional Chinese medicine gallnut transdermal drug delivery system has high compatibility and adhesion with skin; the substrate layer has high stability; and the transdermal drug delivery system can be adhered to infantile Shenque acupoint (that is, navel), has the advantages of treating an inside disease outside the body of a patient, treating and preventing, avoiding injection and administration, being accepted by sick children and parents easily, along with simplicity, convenience and high operability.

The invention relates to a cataplasm for curing acute injury of soft tissues and a preparation method thereof. The cataplasm is prepared by raw materials of angelica extract, saposhnikoviae radix extract, bitter orange extract, anemarrhena asphodeloides extract, rhizoma arisaematis (processed) extract, fructus trichosanthis extract, angelica dahurica extract, carthamus tinctorius extract, thunberg fritillary bulb extract and suitable accessories. The cataplasm consists of rear lining layers, ointments containing drugs, and cover lining layers. The cataplasm takes effect quickly, performances of moisture and air permeability are good, usage is comfortable and convenient, irritation on skins is small, and compliance of patients is high.

The invention discloses frovatriptan inhalation aerosol powder which comprises frovatriptan micro-powder and carrier micro-powder. The particle sizes of the frovatriptan micro-powder are d10=0.8-1.8 micrometers, d50=1.5-4.5 micrometers and d90=3.0-9.0 micrometers, the particle sizes of more than 95% of the frovatriptan micro-powder are smaller than 10 micrometers, the particle sizes of the carrier micro-powder are d10=20-45 micrometers, d50=80-110 micrometers and d90=120-180 micrometers, and the weight ratio of the frovatriptan micro-powder to the carrier micro-powder is 1:(1-1000). A preparation method of the frovatriptan inhalation aerosol powder includes the steps of frovatriptan micronizing, carrier micronizing, carrier granulation, mixing and sub-packaging. Capsules are filled with the blended powder by a micro-capsule filling machine, and the powder is sub-packaged to prepare the capsules containing the frovatriptan inhalation aerosol powder, and the filling amount of each capsule is 1-200mg. The frovatriptan inhalation aerosol powder includes a nasal inhalation mode and an oral inhalation mode, and frovatriptan can exist in a physiological salt form. The frovatriptan inhalation aerosol powder is high in bioavailability and rapid in effect.

The invention relates to a nasal spray or aerosol containing Fasudil. The active component in the preparation can be absorbed rapidly through the nasal mucosa so that the response is rapid. The nasal spray or aerosol has the advantages of high bioavailability and good compliance, and is convenient in use and carrying. The preparation provided by the invention contains Fasudil hydrochloride and pharmaceutically acceptable excipients.

The invention discloses a retooling human granulocyte colony stimulating factor microemulsion to medicinal technique, which comprises the following steps: allocating mass ratio of retooling human granulocyte colony stimulating factor, surface activator, cosurfactant, oil phase and water phase at 1 : (1-5) : (0. 5-3) : (1-3) : (500-2000); adding the retooling human granulocyte colony stimulating factor into oil phase; stirring evenly; dispersing in water phase; getting the product. This product is fit for treat neutrophilic granulocytopenia, which can keep bioavailability with the same effect in injection give medicine.

The invention relates to a raloxifene emplastrum and a preparation method thereof. Raloxifene microemulsion is made into a transdermal emplastrum which is divided into an anti-adhesion layer, a viscose layer, a backlining layer and a medicine storage layer. The raloxifene microemulsion taken as a medical ingredient of the raloxifene emplastrum comprises the following ingredients: raloxifene taken as an active ingredient, polysorbate taken as surfactant, propanediol taken as cosurfactant, pure water or distilled water, and the like. Except for the medical ingredient, a plurality of nonpolar polymers, plasticizing agent, caking agent, transdermal enhancing agent and antioxidant are also added in the emplastrum. Compared with the prior dosage forms, such as tablets, the invention has the remarkable advantages of durable medical effect, safety, low toxicity, simple, convenient and sanitary, and accurate medical dosage.

The invention relates to the field of biomedicines, and particularly relates to an insulin sustained-release oral patch as well as a preparation method and an application thereof. The pharmaceutical preparation is characterized by comprising nanoparticles and pharmaceutical excipients that comprise a filler, an adhesive and a lubricant. The dosage form of the pharmaceutical preparation is an oral patch. According to the invention, insulin is prepared into the sustained-release oral patch, thereby avoiding first-pass effect of gastrointestinal tracts, prolong action time of the medicine, improving curative effect and economic benefit of the medicine, reducing influence of enzymes on the insulin, and relieving pain of patients due to injection. The oral patch of the present invention is high in adhesive capacity, good in release and moderate in dissolution rate.

The invention relates to fasudil-containing oral spray or aerosol in which active constituents can be quickly absorbed through the mouth mucosa to work quickly; and the spray or the aerosol has the advantages that the spray or the aerosol is high in bioavailability, excellent in compliance, portable, convenient to use and the like. The spray or the aerosol comprises the following constituents: fasudil hydrochloride, and pharmaceutically acceptable accessories selected from buffering agent, osmotic pressure regulator, flavoring agent, preservative, absorbefacient, antioxidant, bioadhesive agent, pH modifier, dissolvent and the like.

The invention relates to a traditional Chinese medicine composition for relieving primary dysmenorrhea, a preparation method of the traditional Chinese medicine composition and a dysmenorrhea patch, belongs to the technical field of traditional Chinese medicines, and solves the problem that in the prior art, pain of primary dysmenorrhea cannot be relieved. The traditional Chinese medicine composition for relieving primary dysmenorrhea provided by the invention is prepared from 2-3 parts of peach kernels, 2-3 parts of flos carthami, 3-5 parts of radix angelicae sinensis, 1-2 parts of olibanum, 1-2 parts of myrrh, 3-5 parts of radix cyathulae, 3-5 parts of garden balsam stems, 2-3 parts of rhizoma curcumae longae, 3-5 parts of ramulus mori, 1-2 parts of fructus viticis, 3-5 parts of cassia twigs and 1-2 parts of trogopterus dung. The invention further provides a preparation method of the traditional Chinese medicine composition and the dysmenorrhea patch containing the traditional Chinese medicine composition components. The traditional Chinese medicine composition is suitable for treating primary dysmenorrhea of common gynecological diseases.

The invention relates to a method for preparing a composition capable of resisting infectious diseases. The method comprises the following steps: S1: drawing blood plasma from infection-free recovered patients at a recovery period of the infectious diseases; S2, extracting protein from the blood plasma to obtain crude protein extract; S3: freeze-drying the crude protein extract to obtain powder, namely the composition capable of resisting the infectious diseases. The invention further relates to the composition capable of resisting the infectious diseases, which is prepared by the method, and also relates to atomization spray capable of resisting the infectious diseases, which is prepared from the composition. The composition and the atomization spray, provided by the invention, contain antibodies aiming at corresponding infectious diseases and can be used for treating and preventing the infectious diseases.