Lappaconitine transdermal patch and preparation method thereof

A technology of high uridine and transdermal patches, which is applied in sheet-like delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of large side effects and addiction, and achieve short production cycle, Easy to use and long-lasting effects

Inactive Publication Date: 2009-11-11
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, Western medicine is the main drug for treating pain, which is mainly divided into two types: non-steroidal anti-inflammatory analgesics and narcotic analgesics. Addictive, although non-steroidal anti-inflammatory analgesics do not have such a large side effect of narcotic analgesics, but there are also many negative adverse reactions such as gastrointestinal tract

Method used

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  • Lappaconitine transdermal patch and preparation method thereof
  • Lappaconitine transdermal patch and preparation method thereof
  • Lappaconitine transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Example 1: Gao Ujiasu Patch

[0112] High uricine: 0.5kg lauryl nitrogen Ketones: 1kg

[0113] Acrylic pressure sensitive adhesive: 10kg;

[0114] Take 0.5kg of quinine, add 10kg of acrylic pressure-sensitive adhesive and lauryl nitrogen 1 kg of ketone was dissolved and mixed to prepare a solution; the above solution was coated on the backing layer by the salivation process, and the solvent was evaporated to dryness, and after cooling, the protective layer was covered to obtain the Gaowujiasu patch.

Embodiment 2

[0115] Example 2: Gao Ujiasu Patch

[0116] Polyurine: 1kg Menthol: 0.5kg

[0117] Polyisobutylene pressure sensitive adhesive: 12kg;

[0118] Take 1 kg of quinine, add 12 kg of polyisobutylene pressure-sensitive adhesive and 0.5 kg of menthol, dissolve and mix, and prepare a solution; use the salivation process to coat the above solution on the backing layer until the solvent is evaporated, and after cooling Cover it with a protective layer to get the Gaowujiasu patch.

Embodiment 3

[0119] Embodiment 3: Gao Ujiasu patch

[0120] High Urine: 1.5kg Transdermal Absorption Accelerator: 1.5kg

[0121] Polysiloxane pressure sensitive adhesive: 8kg;

[0122] Take 1.5 kg of quinine, add 8 kg of polysiloxane pressure-sensitive adhesive and 1.5 kg of propylene glycol, dissolve and mix, and prepare a solution; use the salivation process to coat the above solution on the backing layer until the solvent evaporates, After cooling, cover with a protective layer to obtain Gaowujiasu patch.

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Abstract

The invention discloses a lappaconitine transdermal patch and preparation method thereof. The patch comprises a back sheet, a drug storing layer and a protection layer, wherein, the drug storing layer is composed of the raw materials of lappaconitine and pressure sensitive adhesive, or a right amount of transdermal accelerant is added to finally prepare lappaconitine transdermal patch. The lappaconitine transdermal patch of the invention has the advantages of convenient use, high bioavailability and lasting action, avoids first-pass effect of liver as well as damage to gastrointestinal tract, reduces drug toxicity and side effect, improves bioavailability of drug and safety of treatment, and has obvious effect on anti-inflammatory and analgesia.

Description

technical field [0001] The present invention relates to a transdermal patch and a preparation method thereof, in particular to a homogenate transdermal patch and a preparation method thereof. Background technique [0002] Pain is the most common multiple co-symptom in clinical diseases of medical research, and this conundrum is a great challenge for researchers and doctors. Nowadays, Western medicine is the main drug for treating pain, which is mainly divided into two types: non-steroidal anti-inflammatory analgesics and narcotic analgesics. It is addictive. Although non-steroidal anti-inflammatory analgesics do not have such a large side effect of narcotic analgesics, they also have many negative adverse reactions such as gastrointestinal tract. The medical field is also constantly seeking anti-inflammatory analgesics with good analgesic effect and minimal side effects. [0003] [0004] Molecular formula of homogenin Hydrobromide molecular formula of homogenin [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/439A61K47/44A61P29/00A61K47/10A61K47/14A61K47/22A61K47/26A61K47/32A61K47/34
Inventor 刘海龙高虹黄玉兰陈丽娟
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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