Transdermal drug delivery system for treating infantile diarrhea and preparation method thereof
A drug delivery system and technology for infantile diarrhea, applied in the field of transdermal drug delivery system for treating infantile diarrhea and its preparation, can solve the problems of inconvenient use, unsatisfactory cure rate, and long course of treatment for patients, and achieve convenient treatment and avoid bleeding. Peak and valley fluctuation of drug concentration, quick effect
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Embodiment 1
[0023] After mixing 0.5g Galla gall extract with 50.0g polyisobutylene pressure-sensitive adhesive, 11.0g ethyl acetate, 15.0g ethylene glycol, 18.0g succinic acid and 5.5g oleic acid, spread it evenly on the non-woven fabric. Galla gall extract content in the layer is 0.1mg / cm 2 ; After drying at 20°C, cover the siliconized paper on the other side of the matrix layer and cut it into an area of 45cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.
[0024] 10 cases of children with diarrhea were treated with the transdermal drug delivery system for 3 courses of treatment, and the effective rate was 92%.
Embodiment 2
[0025] Example 2: After mixing 55.0g gallnut extract with 15.0g silicone rubber pressure-sensitive adhesive, 8.0g ethanol, 8.0g mineral oil, 9.0g citric acid and 5.0g N-methylpyrrolidone, evenly spread it on the stretch cloth , the content of Galla gall extract in the stroma layer is 10mg / cm 2 ; After drying at 80°C, cover the polyethylene film on the other side of the matrix layer and cut it into an area of 55cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.
[0026] 14 cases of children with diarrhea were treated with the transdermal drug delivery system for one course of treatment, and the effective rate was 100%.
Embodiment 3
[0027] Example 3: After mixing 5.0g Galla extract with 45.0g polyacrylate pressure-sensitive adhesive, 20.0g acetone, 15.0g propylene glycol, 15.0g cyclopentadiene and 3.0g ethylene glycol, evenly spread it on the composite aluminum foil Above, the content of Galla gall extract in the stroma layer is 9mg / cm 2 ; After drying at 60°C, cover the polystyrene film on the other side of the matrix layer and cut it into an area of 55cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.
[0028] 18 cases of children with diarrhea were treated with the transdermal drug delivery system for 2 courses of treatment, and the effective rate was 94%.
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