Transdermal drug delivery system for treating infantile diarrhea and preparation method thereof

A drug delivery system and technology for infantile diarrhea, applied in the field of transdermal drug delivery system for treating infantile diarrhea and its preparation, can solve the problems of inconvenient use, unsatisfactory cure rate, and long course of treatment for patients, and achieve convenient treatment and avoid bleeding. Peak and valley fluctuation of drug concentration, quick effect

Inactive Publication Date: 2011-02-16
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some external application methods have good curative effect, but the course of treatment is long, the cure rate is not ideal, and it is inconvenient for patients to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] After mixing 0.5g Galla gall extract with 50.0g polyisobutylene pressure-sensitive adhesive, 11.0g ethyl acetate, 15.0g ethylene glycol, 18.0g succinic acid and 5.5g oleic acid, spread it evenly on the non-woven fabric. Galla gall extract content in the layer is 0.1mg / cm 2 ; After drying at 20°C, cover the siliconized paper on the other side of the matrix layer and cut it into an area of ​​45cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.

[0024] 10 cases of children with diarrhea were treated with the transdermal drug delivery system for 3 courses of treatment, and the effective rate was 92%.

Embodiment 2

[0025] Example 2: After mixing 55.0g gallnut extract with 15.0g silicone rubber pressure-sensitive adhesive, 8.0g ethanol, 8.0g mineral oil, 9.0g citric acid and 5.0g N-methylpyrrolidone, evenly spread it on the stretch cloth , the content of Galla gall extract in the stroma layer is 10mg / cm 2 ; After drying at 80°C, cover the polyethylene film on the other side of the matrix layer and cut it into an area of ​​55cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.

[0026] 14 cases of children with diarrhea were treated with the transdermal drug delivery system for one course of treatment, and the effective rate was 100%.

Embodiment 3

[0027] Example 3: After mixing 5.0g Galla extract with 45.0g polyacrylate pressure-sensitive adhesive, 20.0g acetone, 15.0g propylene glycol, 15.0g cyclopentadiene and 3.0g ethylene glycol, evenly spread it on the composite aluminum foil Above, the content of Galla gall extract in the stroma layer is 9mg / cm 2 ; After drying at 60°C, cover the polystyrene film on the other side of the matrix layer and cut it into an area of ​​55cm 2 Quadrilateral, that is, the transdermal drug delivery system is obtained.

[0028] 18 cases of children with diarrhea were treated with the transdermal drug delivery system for 2 courses of treatment, and the effective rate was 94%.

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PUM

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Abstract

The invention discloses a transdermal drug delivery system for treating infantile diarrhea. The transdermal drug delivery system consists of a substrate layer, a backing layer and a protective film; and the substrate layer comprises the following components in percentage by weight: 0.5 to 55 percent of gallnut extract, 5 to 60 percent of adhesive, 3 to 20 percent of organic solvent, 1 to 20 percent of plasticizer, 2 to 30 percent of thickening agent, and 1 to 10 percent of penetration enhancer. The substrate layer of the traditional Chinese medicine gallnut transdermal drug delivery system has high compatibility and adhesion with skin; the substrate layer has high stability; and the transdermal drug delivery system can be adhered to infantile Shenque acupoint (that is, navel), has the advantages of treating an inside disease outside the body of a patient, treating and preventing, avoiding injection and administration, being accepted by sick children and parents easily, along with simplicity, convenience and high operability.

Description

technical field [0001] The invention relates to the technical field of transdermal drug delivery system and medicine, in particular to a transdermal drug delivery system for treating infantile diarrhea and a preparation method thereof. Background technique [0002] Transdermal drug delivery systems (trandermal therapeutic systems, TTS) are administered on the surface of the skin so that the drug enters the blood at a constant rate (or close to a constant rate) through the skin without accumulating under the skin, which is different from preparations that act on the skin or subcutaneous local tissues (such as Ointment, plaster, paint, aerosol, etc.) have the following advantages: (1) avoid the liver first-pass effect and gastrointestinal fire extinguishing that may occur after oral administration, improve the therapeutic effect, and reduce toxic and side effects; transdermal administration Time continues to diffuse into the blood circulation. (2) The drug is controlled to be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K47/34A61K47/46A61P1/10A61K9/70A61K47/44A61K47/32A61K47/02
Inventor 何道航李新伟
Owner SOUTH CHINA UNIV OF TECH
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