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Composition and atomization spray capable of resisting infectious diseases and preparation method of composition

An infectious disease and anti-infection technology, applied in the direction of antiviral agents, anti-infective drugs, chemical instruments and methods, etc., can solve the problems of limited promotion, achieve the effect of expanding the scope of use, low biological activity, and maintaining biological activity

Inactive Publication Date: 2017-06-20
江苏安泰生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, passive immunotherapy is generally carried out by intravenous infusion, which is also the limitation of this method. Blood matching must be carried out before infusion, which limits the promotion of this method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1. The atomized spray of anti-H1N1 type influenza

[0024] In the present embodiment, the atomized spray against H1N1 type influenza is prepared by the following method:

[0025] 1) Extract plasma from recovered patients within six months after recovering from H1N1 influenza;

[0026] 2) Take the plasma, dilute it with normal saline, slowly add saturated ammonium sulfate solution drop by drop while stirring until the final concentration of ammonium sulfate is 50%, let stand at 4°C for 6 hours or overnight, centrifuge at 4000r / min for 15-30min, separate the precipitate, and remove the precipitate Dissolved in normal saline, concentrated by ultrafiltration and desalination to obtain a crude protein extract containing antibodies against H1N1 influenza virus;

[0027] 3) Add 0.03 mg / ml ascorbic acid to the crude protein extract as a protein protectant, and then make a lyophilized powder;

[0028] 4) Cobalt treatment at 10°C 60 Irradiation for virus inactivatio...

Embodiment 2

[0031] Embodiment 2. The atomized spray of anti-HPV infection

[0032] In the present embodiment, the atomized spray of anti-HPV infection is prepared by the following method:

[0033] 1) Plasma was extracted from the recovered patients within six months after recovering from HPV infection;

[0034] 2) Take the plasma, dilute it with normal saline, slowly add saturated ammonium sulfate solution drop by drop while stirring until the final concentration of ammonium sulfate is 50%, let stand at 4°C for 6 hours or overnight, centrifuge at 4000r / min for 15-30min, separate the precipitate, and remove the precipitate Soluble in normal saline, desalted and concentrated by ultrafiltration to obtain a crude protein extract containing antibodies against HPV;

[0035] 3) Add 0.03 mg / ml ascorbic acid to the crude protein extract as a protein protectant, and then make a lyophilized powder;

[0036] 4) Cobalt treatment at 10°C 60 Irradiation for virus inactivation treatment, the irradiati...

Embodiment 3

[0039] Embodiment 3. the atomized spray of anti-avian influenza virus infection

[0040] In the present embodiment, the atomized spray of anti-avian influenza virus infection is prepared by the following method:

[0041] 1) Plasma was extracted from the recovered patients within six months after recovering from avian influenza virus infection;

[0042] 2) Take the plasma, dilute it with normal saline, slowly add saturated ammonium sulfate solution drop by drop while stirring until the final concentration of ammonium sulfate is 50%, let stand at 4°C for 6 hours or overnight, centrifuge at 4000r / min for 15-30min, separate the precipitate, and remove the precipitate Soluble in normal saline, desalinated and concentrated by ultrafiltration to obtain a crude protein extract containing antibodies against avian influenza virus;

[0043] 3) Add 0.03 mg / ml ascorbic acid to the crude protein extract as a protein protectant, and then make a lyophilized powder;

[0044] 4) Cobalt treatm...

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PUM

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Abstract

The invention relates to a method for preparing a composition capable of resisting infectious diseases. The method comprises the following steps: S1: drawing blood plasma from infection-free recovered patients at a recovery period of the infectious diseases; S2, extracting protein from the blood plasma to obtain crude protein extract; S3: freeze-drying the crude protein extract to obtain powder, namely the composition capable of resisting the infectious diseases. The invention further relates to the composition capable of resisting the infectious diseases, which is prepared by the method, and also relates to atomization spray capable of resisting the infectious diseases, which is prepared from the composition. The composition and the atomization spray, provided by the invention, contain antibodies aiming at corresponding infectious diseases and can be used for treating and preventing the infectious diseases.

Description

technical field [0001] The invention relates to the field of treating infectious diseases, and more particularly relates to an anti-infectious disease composition, an atomized spray and a preparation method thereof. Background technique [0002] Passive immunotherapy is a short-term immunity produced by injecting the serum of animals that have acquired immunity into the unimmunized body. The antibodies in the body are not produced by themselves but obtained from the outside. Artificial passive immunization is the injection of immune serum containing specific antibodies or purified immunoglobulin antibodies, or injection of cellular immune preparations such as cytokines, so that the body can immediately acquire specific anti-infection immunity and play a role in time. [0003] Collecting plasma / serum / whole blood from convalescent patients for the treatment of critically ill patients belongs to passive immunization and has been applied to many diseases, such as during the spre...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K9/12A61P31/00A61P31/18A61P31/16A61P1/04A61P31/14
CPCA61K9/0078A61K9/12A61K47/22A61K2039/505C07K16/084C07K16/10C07K16/1018C07K16/1045C07K16/121Y02A50/30
Inventor 闫小君罗进
Owner 江苏安泰生物技术有限公司
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