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Inhalation spray of antivirus medicines

An antiviral and spray technology, applied in the field of biomedicine, can solve the problems of low bioavailability, large drug dosage, large toxic and side effects, etc., and achieve the effects of high bioavailability, fast blood flow, and drug saving

Pending Publication Date: 2020-06-19
宁波合康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to provide a brand-new inhalation spray of antiviral drugs in order to overcome the defects of large drug dosage, large toxic and side effects, low bioavailability, and slow onset of action in the above-mentioned Table 1 drugs.

Method used

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  • Inhalation spray of antivirus medicines
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  • Inhalation spray of antivirus medicines

Examples

Experimental program
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Effect test

preparation example Construction

[0065] The preparation method of the above-mentioned spray is as follows: under GMP production conditions, the active agent, auxiliary agent and taste-masking agent are weighed according to the proportion of the prescription, and slowly added to the solvent or mixed solvent respectively, stirred until completely dissolved, filtered and filled in the In the above-mentioned spraying device, pack and get final product.

[0066] The method of using the spray is as follows: the spray can be filled in an air compression atomizer, a heating atomizer, a vibrating screen microporous atomizer, an ultrasonic atomizer and other atomization devices. Which drug delivery device to use and how to inhale the spray depends on actual needs.

[0067] The following is the specific implementation process of the present invention:

[0068] If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature i...

Embodiment 1

[0070] A drug inhalation spray against novel coronavirus.

[0071] Uses: Prevention and treatment of novel coronavirus and other epidemic viral infections.

[0072] prescription:

[0073]

[0074] Preparation:

[0075] (1) Take the prescribed amount of water, mannitol, propylene glycol, hydroxychloroquine sulfate, essence; (2) filter after completely dissolving; (3) quantitative filling; (4) pack.

[0076] Quality Evaluation:

[0077]

[0078] The drug spray is loaded into a suitable atomization device, so that the atomized particle size formed by atomization is 1-5 μm, and the drug is mainly deposited in the terminal alveoli of the lungs (in the terminal 5-6 bronchi).

Embodiment 2

[0080] A drug inhalation spray against novel coronavirus.

[0081] Uses: Prevention and treatment of novel coronavirus and other coronavirus infections

[0082] prescription:

[0083]

[0084] Preparation:

[0085] (1) Take the prescribed amount of water, xylitol, propylene glycol, hydroxychloroquine sulfate, and azithromycin lactobionate; (2) filter after completely dissolving; (3) quantitative filling; (4) packaging.

[0086] Quality Evaluation:

[0087]

[0088] The drug spray is loaded into a suitable atomization device, so that the atomized particle size formed by atomization is 1-5 μm, and the substance is mainly deposited in the terminal alveoli of the lungs (in the terminal 5-6 bronchi).

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Abstract

The invention relates to an inhalation spray of antivirus medicines. The inhalation spray comprises the following components in percentage by mass of 0%-30% of antivirus activity agents, 0%-30% of auxiliary agents, 0%-30% of taste masking agents and the balance solvents, wherein the content of the antivirus activity agents and the content of the auxiliary agents are not 0% at the same time. Compared with the prior art, the inhalation spray disclosed by the application has the purpose that during outbreak period of epidemic corona viruses and other viruses, people do not need to occupy medicalresources in short supply and only need to inhale the antivirus medicines into respiratory tracts, medicine administration is accurately targeted, and the objective of preventing virus infection and propagation can be achieved; in addition, through united medication of the antivirus activity agents and the auxiliary agents, besides, various medicines are inhaled into the respiratory tract of a patient, synergistic treatment effects are generated, the viruses are eliminated, and serious respiratory tract and infection and serious pulmonary infection caused by the viruses can be treated; and chloroquine type antivirus medicines and macrocyclic antibiotics are inhaled through spraying for united medication, and the dosage of the medicines can be notably reduced, so that side effects of prolonged QT intervals, Tdp and sudden cardiac death caused by the medicines can be reduced.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an antiviral drug inhalation spray, in particular to an anti-new coronavirus COVID-19 drug inhalation spray. Background technique [0002] According to the data released by the World Health Organization, there are 600-120 million influenza cases in the world every year, of which 3-5 million are severe influenza, and 250-500 thousand people die from influenza each year. In recent years, the spread of A / H1N1 virus, A / H3N2 virus, and B influenza virus worldwide, as well as frequent outbreaks of influenza virus such as H7N9, H5N1, and H5N8 avian influenza, have always threatened human health and life safety, affecting People's daily life hinders the country's economic development. The recent global outbreak of novel coronavirus (COVID-19) pneumonia, common fever, cough, dyspnea, more severe acute respiratory distress syndrome, septic shock, etc., can lead to death of patients. Due to its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K45/06A61P31/14A61P11/00A61K31/4706A61K31/7052A61K31/215
CPCA61K9/0078A61K31/215A61K31/4706A61K31/7052A61K45/06A61K47/10A61P11/00A61P31/14A61K2300/00
Inventor 施雄伟王伟
Owner 宁波合康生物医药科技有限公司
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