Treatment cancers using combination comprising parp inhibitors, temozolomide and/or radiation therapy

An inhibitor, cancer technology, applied in the directions of X-ray/γ-ray/particle irradiation therapy, drug combination, medical preparations containing active ingredients, etc., can solve the problem of insufficiently obtained, undisclosed clinical benefits, and aggravate the adverse effects of myelosuppression and other issues to achieve an effective anti-tumor response
CN110891576AInactive Publication Date: 2020-03-17百济神州(苏州)生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
百济神州(苏州)生物科技有限公司
Publication Date
2020-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R) -2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, incombination with temozolomide and / or radiation therapy. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R) -2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with temozolomide and the use thereof.
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Description

[0001] related application

[0002] This application claims the benefit of International Patent Application No. PCT / CN2017 / 093192 filed on July 17, 2017, the disclosure of which is hereby incorporated by reference in its entirety for all purposes. technical field

[0003] Disclosed herein is a method for preventing cancer, delaying the progression of cancer, or treating cancer in a subject, the method comprising administering to a subject in need a therapeutically effective amount of a PARP inhibitor and a therapeutically effective amount of temozolomide and / or A combination of radiation therapies.

[0004] Background of the invention

[0005] One of the hallmarks and driving forces of cancer is genetic instability [Hanahan D and Weinberg R A, Hallmarks of cancer: the next generation. Cell, 2011.144(5): pp. 646-74.]. Particularly in familial cancers, mutations in the breast cancer susceptibility BRCA1 and BRCA2 tumor suppressor genes, key players in homologous recombination ...

Claims

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