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Pyraclostrobin nanoparticle and preparation method of pyraclostrobin nanoparticle

A technology of pyraclostrobin and nano-microspheres, which is applied in the field of pesticides and can solve the problems of polluting the ecological environment, poor quick-acting performance, and waste of resources.

Inactive Publication Date: 2014-12-17
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Of the existing preparations of pyraclostrobin, only the emulsifiable concentrate formulation has been registered as a pesticide
The emulsifiable concentrate preparations contain a large amount of volatile organic solvents, which are discharged into the environment, which not only pollutes the ecological environment, but also causes waste of resources; conventional pesticide preparations are quick-acting, and have a short duration in the growth period of crops, requiring multiple application, reducing the The utilization rate of pesticides increases the amount of pesticide application and labor costs
Generally, the particle size of microspheres is micron-scale, which has a longer sustained release time, and its disadvantage is that the quick-acting effect is poor, while nano-microspheres have a faster release rate than conventional microspheres due to their nano-scale particle size, but their persistence Shorter than conventional microspheres and higher than conventional emulsifiable concentrate formulations, it has both quick-acting and sustained-release effects

Method used

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  • Pyraclostrobin nanoparticle and preparation method of pyraclostrobin nanoparticle
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  • Pyraclostrobin nanoparticle and preparation method of pyraclostrobin nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Example 1 : Preparation of 17.2% pyraclostrobin nanospheres

[0019] Weigh an appropriate amount of poly(lactic-co-glycolic acid) (PLGA) and pyraclostrobin technical substance into dichloromethane, ultrasonically dissolve it completely, and prepare a preparation containing 5 mg / mL pyraclostrobin and 20 mg / mL PLGA. dichloromethane solution. Under magnetic stirring, the dichloromethane solution in which the polymer and the original drug were dissolved was added dropwise to a 2% (W / V) aqueous solution of gum arabic at an oil-to-water ratio of 1:4, and stirred rapidly for 5 minutes. Ultrasonic crush the mixture for 54S (99W, 2s each time, 8s interval) to obtain an O / W emulsion, remove the organic solvent by rotary evaporation for 15min, and finally centrifuge at 9000r / min for 15min, pour off the supernatant, and the precipitate after centrifugation The mixture was washed three times with deionized water and freeze-dried to obtain pyraclostrobin nanospheres. Its embedding...

Embodiment 2

[0021] Example 2 : Preparation of 40.5% pyraclostrobin nanospheres

[0022] The concentrations of PLGA and pyraclostrobin are both 20 mg / mL, the water phase is 2% aqueous solution of gum arabic, and other preparation methods are the same as in Example 1. The prepared microspheres have a drug loading capacity of 40.5%, an embedding rate of 76%, and a volume median diameter of 0.57 μm. It can be seen that increasing the dosage of pyraclostrobin can prepare nano-microspheres with high drug loading.

Embodiment 3

[0023] Example 3 : Preparation of 24.2% pyraclostrobin nanospheres

[0024] The carrier is polycarbonate, the concentration is 20 mg / mL, the concentration of pyraclostrobin is 10 mg / mL, the water phase is 2% gum arabic aqueous solution, and other preparation methods are the same as in Example 1. The prepared microspheres had a drug loading capacity of 24.2%, an embedding rate of 69%, and a volume median diameter of 0.58 μm.

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Abstract

The invention discloses a pyraclostrobin nanoparticle and a preparation method of the pyraclostrobin nanoparticle. The pyraclostrobin nanoparticle is prepared by adopting an ultrasonic emulsification-volatilization method; a solid spherical nanoparticle is prepared by taking polyester as a carrier and taking arabic gum as a dispersing agent; and the drug loading capacity of the prepared nanoparticle is 5.0-30%, the embedding rate is 65-90%, and the volume immediate diameter is about 0.6 micron. The pyraclostrobin nanoparticle disclosed by the invention has quick release and slow release functions, and the lasting period is lower than that of a conventional particle and is higher than that of missible oil. The nanoparticle prepared by the method is secondarily processed into a conventional dosage form, and can be applied to foliar spraying to prevent and treat various diseases of crops.

Description

technical field [0001] The invention belongs to the field of pesticides and relates to a new formulation of pesticides, in particular to pyraclostrobin nano-microspheres and a preparation method thereof. Background technique [0002] The effective utilization rate of conventional pesticide spraying is only 20% to 30%. Most of the active ingredients of pesticides are lost to the atmosphere, soil, water and other environments, which not only pollutes the environment, but also causes a lot of waste. Therefore, developing new pesticide formulations that are safe, environmentally friendly, long-lasting, and reduce environmental pollution is one of the future development directions of pesticide formulations. [0003] Microspheres (Microspheres or Microbeads) are new formulations of pesticides with sustained release function developed in recent years. They are spherical preparations prepared with polymer materials such as starch, chitosan, polylactic acid, and gelatin. The drugs in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/24A01N25/04A01P3/00
Inventor 陈福良郑玉尹明明
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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