50results about How to "High molecular stability" patented technology

The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia/lymphoma, solid tumors, fungal infections, hyperproliferative vascular disorders. Also described is a method for the synthesis of water soluble deuteratred rapamycin compounds and their use as described above.

The present invention relates to an Exendin 4 polypeptide fragment, which has hypoglycemic activity, and can be used for the treatment of type II diabetes mellitus. The polypeptide sequence described herein is HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX₄PX₅, where X₁ represents Phe or Tyr, X₂ represents Met, Ile or Leu, X₃ represents Lys, X₄ represents Gly or deletion, X₅ represents Arg or deletion. Additionally, the present invention relates to a method for the Exendin 4 polypeptide fragment preparation.

The invention provides a composition for increasing fertilizer absorption and utilization rate and application thereof. The composition comprises orange essential oil, an emulsifier and an organic solvent, wherein the orange essential oil comprises, by mass percentage, 10-30% of grapefruit essential oil and 50-70% of orange peel essential oil. A method for increasing the fertilizer absorption andutilization rate includes: adding the composition into fertilizer, evenly mixing, and applying the fertilizer to crops. The composition has the advantages that the orange essential oil in the composition can increase molecular stability in humic acid, the problems of alginic acid fertilizer gas expansion and solid fertilizer moisture absorption are solved, the orange essential oil can carry fertilizer components to fast penetrate leaves to enter the bodies of plants, and the absorption and utilization rate of humic acid fertilizer, alginic acid fertilizer, amino acid fertilizer, oligosaccharide fertilizer and fish protein fertilizer can be increased.

Specific antibodies against N-procalcitonin, peptides, genetic constructions and methods for the obtainment of the peptides used in the obtainment of the antibodies. These antibodies can be used for preparing drugs, or diagnostic kits for diseases that develop with systemic inflammatory response or metabolic stress.

Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.

The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.

Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I): H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X1-Gln-X2-Ala-Val-X3-X4-Tyr-Leu-X5-X6 (I) wherein X1, X3 and X4 represent Lys or Arg, respectively; X2 represents Met, Leu or nLeu; X5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu or Asn-Ser-Ile-Leu-Asn-X7 (wherein X7 represents a chemical bond, Gly, etc.); and X6 represents -OH or -NH2, or pharmaceutically acceptable salts thereof.

A method of treating or preventing cardiovascular disease which comprises administering a therapeutically effective amount of at least one n-3 DPA-derived resolvin and/or upregulating or increasing the biosynthesis or activity of at least one n-3 DPA-derived resolvin. n-3 DPA-derived resolvins are normally regulated diurnally in the body and are linked to activation of platelets and leucocytes and formation of platelet-leukocyte aggregates. Dysfunctional regulation of n-3 DPA-derived resolvins may lead to systemic inflammation because of excessive inflammation-inducing eicosanoids, especially in the early hours of the morning. Further, decreased 5-LOX/15-LOX expression and increased systemic adenosine concentrations are found to be associated with reduced resolvin levels and increased risk of cardiovascular disease. n-3 DPA-derived resolvins are administered to achieve maximum absorption in the early hours. Also disclosed are n-3 DPA-derived resolvins for use in the treatment or prevention of cardiovascular disease, and methods for measuring the levels of n-3 DPA-derived resolvins and/or the expression or activity of adenosine or 5-LOX/15-LOX in biological samples obtained from a subject for assessing the subject's risk of cardiovascular disease.

A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxidant, and is used for treating damage to skin comprising applying the topical composition to the skin.

It is intended to provide a novel amyloid protein (human variant amyloid protein) useful as an antigen molecule or the like for improving a vaccine therapy. This human variant amyloid protein is a protein with deletion of Glu at 22nd, Ala at 21st, or Asp at 23rd in a normal (wildtype) amyloid protein (Aβ1-40, Aβ1-42, or Aβ1-43) consisting of 40, 42, or 43 amino acids.

The invention relates to a preparation method of a high-temperature-resistant gas-sensitive material and belongs to the technical field of gas sensor technologies. The method comprises the following steps: taking corn straws, corn leaves and rice hulls as raw materials and putting the same into hydrochloric acid to soak and dissolve part of tissue fibers, separating the plant fibers, corroding byusing citric acid so as to modify a fiber tube, so that the roughness degree of the tube wall of the fiber tube is increased, meanwhile, introducing a large amount of carboxyl group chelating zinc ions and generating nano-scale zinc oxide molecules through the reaction of diethylamine, adsorbing a large amount of zinc ions by the plant fibers through chelating so as to enable the generated nano-zinc oxide to be embedded into the plant fiber tube, and expanding to form holes, thereby increasing the contact area between the nano-scale zinc oxide and the air, and then, carbonizing the plant fibers, so that the zinc oxide molecules exist in the carbon environment, and the zinc oxide is difficult to corrode by external substances, simultaneously, the heat-conduction heat resistance of the carbon fiber is good, the heat resistance of the gas-sensitive material can be obviously improved, and a good application prospect is achieved.

The invention discloses a polyimide waterborne epoxy coating. The polyimide waterborne epoxy coating comprises the following components in parts by weight: 10 parts of waterborne epoxy resin, 50-100 parts of polyimide waterborne epoxy resin, 0.5-2 parts of a curing agent, 0.5-2 parts of a flatting agent, 0.1-1 part of a dispersing agent, 0.2-2 parts of a defoaming agent, 10-20 parts of pigment, 10-100 parts of filler and 50-100 parts of water. A preparation method of the polyimide water-borne epoxy resin comprises the following steps: (1) subjecting 1-amino-3-chloro-2-propanol hydrochloric acid to reacting with chlorosuccinic acid in an alkaline aqueous solution for 1 hour to prepare a solution I; (2) subjecting ethylene glycol disodium to reacting with 3,5-dichlorobenzenesulfonic acid in an alkaline aqueous solution for 0.5 h to prepare a solution II; and (3) mixing the solution I, the solution II and 3-chloro-5-epoxy methylbenzenesulfonic acid, conducting stirring and reacting for 3 hours to prepare the polyimide water-borne epoxy resin. The coating disclosed by the invention has the advantages of high chemical stability, low construction environment requirement, environment friendliness, no toxicity, high water resistance of a cured product and the like, and has prominent popularization prospects.

An environmentally friendly lipstick case formed of PET includes a cap including an internal annular groove on a bottom; a rotation tube including internal spiral guide grooves; an ascending and descending tube including two opposite guide pins on an outer surface, and longitudinal ribs on an inner surface; a support tube including two opposite longitudinal tunnels on a surface, each longitudinal tunnel having an upper horizontal end and a lower horizontal end oriented in a direction opposite to that of the upper horizontal end, and an annular toothed member on a bottom of an inner surface; and a lower exterior casing including an annular shoulder on an outer surface of an upper portion, projections between the annular shoulder and an open top, and a protrusion on a blind bottom disposed in the toothed member. The guide pins are moveably disposed through the longitudinal tunnels into the guide grooves.

A flexible display panel, comprising: a first flexible substrate and a second flexible substrate cell-aligned to each other; a blue phase liquid crystal layer disposed between the first flexible substrate and the second flexible substrate and strip electrodes arranged on the second flexible substrate at a side close to the blue phase liquid crystal layer at intervals; a reflective layer disposed on the second flexible substrate at a side far away from the blue phase liquid crystal layer; and a ¼ wave plate and a polarizer successively arranged on the first flexible substrate at a side far away from the blue phase liquid crystal layer, with an included angle between a light transmitting axis of the polarizer and an optical axis of the ¼ wave plate being 45° and an included angle between each of the strip electrodes and the optical axis of the ¼ wave plate being 90°.