Curcumin micelle nasal solution and preparation method thereof
A technology of nasal administration and curcumin, which is applied in the field of curcumin micellar nasal administration solution and its preparation, can solve the problems of low trigeminal ganglion targeting, side effects, and effective stability of only 3 months. Controllable micellar particle size, improved targeting, and good storage stability
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Embodiment 1
[0024] Put 50 mg curcumin, 30 mg four-arm-polyethylene glycol-maleimide (molecular weight 1000) and 900 mg polyethylene caprolactam-polyvinyl acetate-polyethylene glycol (molecular weight 118000) in a 100 mL round bottom flask, Add 20mL of absolute ethanol, after fully dissolved, evaporate the absolute ethanol in a 40°C water bath in a rotary vacuum to obtain a uniformly dispersed film of drug and copolymer, then add 10mL of phosphate buffer, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10 minutes to obtain gel Beam solution. Cool the micellar solution to 4°C, add 10 mg of RGD peptide to the micellar solution, and continue to incubate at 4°C for 30 minutes after fully dissolving, add preservative benzalkonium chloride, isotonic regulator sodium chloride, and adjust the pH to 7.4. After the micellar solution passes through a 0.22 μm microporous membrane, it can be aseptically dispensed. The average particle size of curcumin micelles measured by laser pa...
Embodiment 2
[0026] Put 50mg curcumin, 50mg four-arm-polyethylene glycol-maleimide (molecular weight 1000) and 1000mg polyethylene caprolactam-polyvinyl acetate-polyethylene glycol (molecular weight 118000) in a 100mL round bottom flask, Add 20mL of absolute ethanol, after fully dissolved, evaporate the absolute ethanol in a 40°C water bath in a rotary vacuum to obtain a uniformly dispersed film of the drug and the copolymer, then add 10mL of phosphate buffer, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10 minutes to obtain gel Beam solution. Cool the micellar solution to 4°C, add 25 mg of RGD peptide to the micellar solution, and continue to incubate at 4°C for 30 minutes after fully dissolving, add preservative benzalkonium chloride, isotonic regulator sodium chloride, adjust the pH to 7.4, and After the micellar solution passes through a 0.22 μm microporous membrane, it can be aseptically dispensed. The average particle size of curcumin micelles measured by las...
Embodiment 3
[0028] Put 50 mg curcumin, 15 mg four-arm-polyethylene glycol-maleimide (molecular weight 1000) and 600 mg polyethylene caprolactam-polyvinyl acetate-polyethylene glycol (molecular weight 118000) in a 100 mL round bottom flask, Add 20mL of absolute ethanol, after fully dissolved, evaporate the absolute ethanol in a 40°C water bath in a rotary vacuum to obtain a uniformly dispersed film of the drug and the copolymer, then add 10mL of phosphate buffer, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10 minutes to obtain gel Beam solution. Cool the micellar solution to 4°C, add 3.75mg RGD peptide to the micellar solution, fully dissolve and continue to incubate at 4°C for 30min, add preservative benzalkonium chloride, isotonic regulator sodium chloride, adjust pH to 7.4, After the micellar solution is passed through a 0.22 μm microporous membrane, it can be aseptically dispensed. The average particle size of curcumin micelles measured by laser particle size ...
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