Method for preparing nano-microballons of Avermectins medicine and usage
A technology of nano-microspheres and abamectin, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve problems such as restrictions on large-scale promotion and use, large impact on the soil ecological environment, and toxic residual effects , to achieve the effect of solving soil ecological problems, reducing the amount of drugs, and reducing toxicity
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Embodiment 1
[0018] Embodiment 1, the preparation method of avermectins and its derivatives ivermectin and doramectin nano-microspheres, the process steps are:
[0019] A. Use biodegradable polylactic acid-co-glycolic acid copolymer (Poly lactic acid-co-glyclic acid, PLGA) as the carrier material, and weigh the drug in the corresponding proportion (content 1%-40%), add dichloro A mixed solvent of methane and acetone makes it dissolve;
[0020] B, preparation concentration is the polyvinyl alcohol (PVA) aqueous solution of 1%-6% concentration, PLGA solution is dispersed in the aqueous solution of PVA with ultrasonic emulsifier, forms oil-in-water emulsion;
[0021] C. After vacuumizing the oil-in-water emulsion to remove the organic solvent for 10 to 24 hours under constant stirring, the prepared nano-microspheres are solidified;
[0022] D. Centrifuge the solidified nano-microspheres on a low-temperature ultracentrifuge at a speed of 10,000 to 40,000 rpm for 20 to 30 minutes to collect th...
Embodiment 2
[0036] Embodiment 2, preparation method, on the basis of embodiment 1, microsphere carrier material is polylactic acid-polyglycolic acid copolymer (PLGA).
Embodiment 3
[0037] Embodiment 3, preparation method, on the basis of embodiment 1, the microsphere of the pharmaceutical dosage form that embeds is below 150nm.
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