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Method for preparing nano-microballons of Avermectins medicine and usage

A technology of nano-microspheres and abamectin, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve problems such as restrictions on large-scale promotion and use, large impact on the soil ecological environment, and toxic residual effects , to achieve the effect of solving soil ecological problems, reducing the amount of drugs, and reducing toxicity

Inactive Publication Date: 2003-10-01
方淑昌 +1
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  • Summary
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AI Technical Summary

Problems solved by technology

As a pesticide, there are toxicity and residual effects, which have a great impact on the soil ecological environment, and problems such as poor stability, low efficacy, and high cost limit the large-scale promotion and use of this biological pesticide.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, the preparation method of avermectins and its derivatives ivermectin and doramectin nano-microspheres, the process steps are:

[0019] A. Use biodegradable polylactic acid-co-glycolic acid copolymer (Poly lactic acid-co-glyclic acid, PLGA) as the carrier material, and weigh the drug in the corresponding proportion (content 1%-40%), add dichloro A mixed solvent of methane and acetone makes it dissolve;

[0020] B, preparation concentration is the polyvinyl alcohol (PVA) aqueous solution of 1%-6% concentration, PLGA solution is dispersed in the aqueous solution of PVA with ultrasonic emulsifier, forms oil-in-water emulsion;

[0021] C. After vacuumizing the oil-in-water emulsion to remove the organic solvent for 10 to 24 hours under constant stirring, the prepared nano-microspheres are solidified;

[0022] D. Centrifuge the solidified nano-microspheres on a low-temperature ultracentrifuge at a speed of 10,000 to 40,000 rpm for 20 to 30 minutes to collect th...

Embodiment 2

[0036] Embodiment 2, preparation method, on the basis of embodiment 1, microsphere carrier material is polylactic acid-polyglycolic acid copolymer (PLGA).

Embodiment 3

[0037] Embodiment 3, preparation method, on the basis of embodiment 1, the microsphere of the pharmaceutical dosage form that embeds is below 150nm.

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PUM

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Abstract

A nanosphere of abamectin used as both medicine and agricultural chemical is prepared through preparing the polylactic acid-polyglycollic acid copolymer (PLGA), mixing abemectin with PLGa, ultrasonicemulsifying, volatilizing solvent, supersonic centrifugal treating, mixing, concentrating, leaching with distilled water, and supersonic centrifugal treating, mixing, concentrating again, and freeze drying at -106- -108 deg.C. Its advantages are slow release, low poison and low cost.

Description

technical field [0001] The invention relates to a preparation method and application of abamectin drug and its derivative ivermectin slow-release nano-microspheres. technical background [0002] Avermectins are currently the most excellent class of broad-spectrum and high-efficiency antiparasitic drugs, and are also the fastest growing and most widely used biomedicine and pesticides in the world. However, as an in vivo drug, the effective blood drug concentration is only maintained for about 68 hours, and the bioavailability is as low as 20%-30%. As a pesticide, it has toxicity, residual effect, great impact on the soil ecological environment, poor stability, low drug efficacy, and high cost, which limit the large-scale promotion and use of this biological pesticide. Contents of the invention [0003] The purpose of the present invention is to aim at the drawback of above-mentioned prior art, provide a kind of adopt biodegradable macromolecular material polylactic acid-po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/50A61K31/7048A61P33/00
Inventor 方淑昌于美丽
Owner 方淑昌
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