80 results about "Avermectines" patented technology

Microencapsulated formulations of macrolide lactones (abamectin, milbemectin, milbemycins emamectin, avermectins, ivermectins) wherein the active ingredient is protected from UV-degradation, with exceptional release characteristics resembling those of an emulsion concentrate or, if desired, of long-lasting effect; further with appropriate rheological properties, and with reduced toxicity. The invention provides a unique microencapsulation process for the chemical stability and biological activity of mectins, e.g. abamectin, and provides microcapsules of mectins to be used in formulations CS, WG / CS, ZC, EC / CS and any formulation type containing microcapsules and combination with other biologically active ingredients.

A nanosphere of abamectin used as both medicine and agricultural chemical is prepared through preparing the polylactic acid-polyglycollic acid copolymer (PLGA), mixing abemectin with PLGa, ultrasonicemulsifying, volatilizing solvent, supersonic centrifugal treating, mixing, concentrating, leaching with distilled water, and supersonic centrifugal treating, mixing, concentrating again, and freeze drying at -106- -108 deg.C. Its advantages are slow release, low poison and low cost.

Compositions and nanoemulsions containing lipid nanocapsules dispersed in a hydrophilic phase, such nanocapsules including at least one avermectin compound, are useful for the treatment of dermatological pathologies, e.g., rosacea.

The invention discloses an avermectin nanometer microemulsion and a preparation method and application thereof. The avermectin nanometer microemulsion comprises following constitutes according to percent by weight: 0.5 percent of avermectin, 1 percent of medicine carrier, 0.95 percent of cosolvent, 15 percent of solvent, 6 percent of surfactant A, 0.1 percent of surfactant B, 0.2 percent of stabilizer and 76.25 percent of water. The prepared avermectin nanometer microemulsion is basically of a spherical shape, is uniform in particle size, is singly dispersed, cannot be adhered, and has high dispersion performance and biological availability, and the technological blank of the avermectin nanometer microemulsion is filled.

The invention discloses tefluthrin-containing combination which contains A active ingredient and B active ingredient, wherein the A active ingredient is tefluthrin and the B active ingredient is avermectin or fosthiazate. The weight ratio of the A active ingredient to the B active ingredient is 40:1-1:20. The combination has obvious synergistic effect and can reduce the dosage of the active ingredients and the pesticide application time. The combination is applicable for prevention and control of various agricultural pests and nematodes.

The invention belongs to the technical field of microorganisms, and particularly relates to a method for preparing avermectin (Avermectins). The method comprises the following steps: cultivating a streptomyces avermitilis strain capable of generating avermectin and genetic improved bacteria thereof in a first stage of fluid nutrient medium, and then inoculating into a second stage of fluid nutrient medium as a seed solution; fermenting and cultivating after inoculating the seed solution into the second stage of fluid nutrient medium, and feeding a sodium propionate precursor to carry out feeding cultivation; collecting the avermectin B1a from fermentation broth after fermentation is finished. The effective method has the characteristics of being high in production efficiency and the like.

The invention relates to a process for preparing avermectin and derivant dimethylamino avermectin, ivermectin, and doramectin slow release nanometer micro-balloon preparation. The technical procedures comprise suspending the suspending solution of 1%-40% unequal avermectin-type medicine, 0%-4% divinylbenzene (cross linking agent), (metyl group) methyl acrylate of 1% BPO (initiating agent) or solvent of methacrylic acid glycidyl ester in an aqueous phase of 40 DEG C with 1% sodium dodecyl benzene sulfonate and 0.5% gelatine or 0.5% PVA (the size ratio of an oil phase and the aqueous phase is 1:3) in a three-mouth bottle with an agitator, a reflux condensing tube and a thermometer, adding numerous ml of 0.5% methylene blue, regulating ultrasonic homogenization power, heating-up to 61 DEG C at 5 DEG C / 10mins after the grain size is even, aggregating for two hours, heating-up to 85 DEG C with the same speed, aggregating for 8 hours and preparing 50nm-100nm avermectin-type medicinal nanometer micro-balloon preparation with different medicine-loading amount, and the packaging and loading rate reaches more than 91%. The invention solves the problem of long-acting controlled release of biological medicament, reduces the toxic and side effect simultaneously, improves the biological availability, reduces the cost and is friendly to the environment.

The invention discloses a methylamino avermectin benzoate soluble particle agent and preparing method in the pesticide product domain, which comprises the following parts: methylamino avermectin benzoate original-drug, beta-cyclodextrin, nonyl phenol polyoxyethylene ether NP40 surface activator, sodium dodecylbenzene sulfonate ABS-Na surface activator, sodium bicarbonate and anhydrous citrate according to certain weight percentage. The manufacturing method comprises the following steps: blending methylamino avermectin benzoate original-drug, beta-cyclodextrin and ABS-Na surface activator in the water, homogenizing under high-pressure, spraying, drying, preparing composite mother drug, dissolving NP40 surface activator to blend with sodium bicarbonate and anhydrous citrate, obtaining plastic agent, squeezing into column shaped particle, drying in the vacuum to produce the drug.

The invention discloses a broad-spectrum pesticide emulsion-in-water formula. The broad-spectrum pesticide emulsion-in-water formula includes, by weight, 1-3% of avermectins, 20-35% of PHMG (polyhexamethylene guanidine), 0.5-1.5% of high-solubility polyvinyl alcohol, 20-40% of organic silicon, and 32-52% of seaweed extract. The problems of decreased pesticide quality, environmental pollution and the like due to excessive use of pesticides can be solved effectively, the broad-spectrum pesticide emulsion-in-water formula is stable in performance, simple, feasible, low-cost and convenient for large-area popularization and application, and agricultural substantial development can be promoted effectively.

The invention elates to a microcapsule suspension-suspending agent containing avermectin and fluopyram, and a preparation method thereof. The preparation method comprises following steps: a, an oil phase material is mixed with a water phase material so as to obtain an O / W emulsion; b, an organic solvent in the O / W emulsion is removed so as to obtain an avermectin microcapsule suspension solution;c, the avermectin microcapsule suspension solution, a first dispersant, a first thickening agent, and a first antifreezing agent are mixed so as to obtain an avermectin microcapsule suspending agent;and d, the avermectin microcapsule suspending agent and a fluopyram suspension solution are mixed so as to obtain the avermectin.fluopyram microcapsule suspension-suspending agent. The avermectin.fluopyram microcapsule suspension-suspending agent containing avermectin and fluopyram is excellent in storage stability, and long in effect lasting period, is capable of reducing medicine application times, reducing medicine using amount, contains no organic solvent, and low environment pollution is caused.

The invention relates to a synthesis method and application of avermectin B2-based emamectin benzoate (YAB), and belongs to the technical field of organic synthesis. The preparation method comprises the following specific steps: sequentially performing a hydroxyl protection reaction, a hydroxyl oxidation reaction, a carbonyl amination reaction, an imine reduction and hydroxyl deprotection reactionand a salt formation reaction on avermectin B2 to obtain a target product YAB. Compared with the currently and widely used avermectin B1-based emamectin benzoate, the product YAB prepared by the synthesis method provided by the invention has the advantages of higher insecticidal activity, lower toxicity and low raw material cost and has significant market advantages.

Physically and chemically stable, oxidation-resistant, cosmetic / dermatological inverse emulsions contain a therapeutically effective amount of at least one avermectin compound, notably ivermectin, a glycolic or aqueous / glycolic dispersed hydrophilic phase, a continuous lipophilic phase and an emulsifier having an HLB ranging from 2 and 7, and are useful for the treatment of a variety of dermatological conditions / afflictions, e.g., rosacea.

Pharmaceutical / dermatological emulsions containing at least one avermectin compound, notably ivermectin, include at least one fatty phase and at least one aqueous phase, the at least one avermectin compound being solubilized in the fatty phase, which emulsions are useful for the treatment of a variety of dermatological conditions / afflictions, in particular rosacea.

The invention discloses an avermectin-resistant Neoseiulus barkeri molecular marker with the nucleotide sequence represented by SEQ ID No.3, and a primer 4F / 4R for amplifying the marker, and also discloses an application of the molecular marker in the avermectin-sensitive line and avermectin-resistant line classification of the Neoseiulus barkeri m, and a detection method of the avermectin-resistant Neoseiulus barkeri molecular marker. The detection method comprises the following steps: extracting total DNA from Neoseiulus barkeri to be detected, carrying out PCR amplification by using the total DNA as a template and using the primer 4F / 4R to obtain a NbGluCl gene fragment containing a mutation region, and carrying out sequence comparison on the obtained gene fragment and the avermectin-resistant Neoseiulus barkeri molecular marker with the nucleotide sequence represented by SEQ ID No.3 in order to judge whether a line is an avermectin-sensitive or avermectin-resistant line or not. The marker has a high specificity and a high stability, and can be used to analyze whether the sample to be detected is the avermectin-sensitive line or the avermectin-resistant line.

The invention discloses a solid-state avermectin particle preparation and a preparation method and application thereof. Particles comprise microspheres and microcapsules. A preparation method of the microspheres includes following steps: 1), dissolving avermectin in an organic solvent to obtain an organic solution of avermectin as an oil phase; 2), dissolving a stabilizer in water to obtain a stabilizer water solution as an outer water phase; 3), mixing the oil phase with the outer water phase for mechanical stirring to obtain an oil-in-water primary emulsion; 4), utilizing a membrane emulsification device to perform membrane filtering on the oil-in-water primary emulsion under action of nitrogen to obtain an oil-in-water emulsion; 5), sequentially stirring and centrifuging the oil-in-water emulsion to collect precipitate, washing with water, and drying to obtain the solid-state avermectin microspheres. A membrane emulsification method is combined with an emulsion solvent evaporation method to obtain the solid-state avermectin microspheres and microcapsule preparation which has the advantages of stability in storage, safety and convenience in transport and use and low cost.

The invention discloses use of a regulatory protein gene in streptomyces avermitilis. The inactivation of the gene can obviously change the ability of the streptomyces avermitilis to generate an avermectin. The regulatory protein gene comprises an avaL2 gene, an avaR1 gene or an avaR2 gene, wherein the gene replaced mutation strains of the avaL2 gene and the avaR1 gene can obviously improve avermectin generating ability and the gene replaced mutation strain of the avaR2 gene can obviously reduce the avermectin generating ability. The invention also discloses a method for generating the streptomyces avermitilis mutation strain by using the genes, and the application of the streptomyces avermitilis mutation strain, wherein the streptomyces avermitilis mutation strain is increased in the yield. Compared with the yield of the avermectin obtained from an unmodified strain, the yield of the avermectin obtained by fermenting the corresponding mutation strain is greatly increased.

The invention discloses a water emulsion containing avermectin and carbosulfan and its preparation method. The water emulsion uses avermectin and carbosulfan as basic components and water as dispersion medium, to be formed into uniform and flowable water emulsion through adding adjuvants and high shear dispersion of a homogenizer. In the invention, the effective components and auxiliary carriers comprises (by wt%) avermectin and carbosulfan composite 5-30, emulsifying agent 1-15, cosolvent 1-15, stabilizer 1-5, dispersant 1-15, antifreezing agent 2-10, antifoaming agent 0.1-1, and water as balance.

The invention discloses a reaction kettle which comprises a vertical cylindrical kettle body, wherein the kettle body is provided with a kettle cover, a viewing mirror, a liquid longitudinal circulation system, a material port, a temperature probe and the like; a cooling jacket is arranged on the outer wall of the kettle body; a stirring device is arranged in the kettle body and penetrates through the kettle top to be connected with a power device; an air-pressure sealing device is arranged outside the rotatable connection part between the stirring device and the kettle top; the stirring is divided into three layers, wherein the three-vane propulsive stirring is performed at the bottom layer, and two-vane inclined-paddle type stirrers are arranged on the two layers above; annular pipes are arranged in the kettle body and connected by fin pipes; the kettle body, the kettle cover, the annular pipes and the fins are all made from 304 steel; and the outer layer is provided with the cooling jacket made from carbon steel. Compared with the existing reaction kettle, the reaction kettle disclosed by the invention has novel design, can mix the materials more sufficiently, improves the heat exchange efficiency, reduces the manufacturing cost, and particularly obviously improves the product conversion efficiency and reaction effect in the production of emamectin benzoate and improves the product quality.

The invention relates to a dressing coccidology killing solution used in steam, wherein the invention is characterized in that: it is formed by avermectin, imidacloprid, shelf element and nitrogen ketone, while their ratio is 0.3-0.5:1.4-1.8:8-12:0.4-0.6. The invention can absorb and kill, to form at the surface of plant, to kill the pest in two hours. And it can kill the pest inside the tree in 4-7 days more than 95%. The dressing agent and drug form micro capsules covering the plant while its effective period is more than one month.

The invention discloses a method for prevention and control of vegetable root-knot nematodiasis with mixed Sr18 biological nematocide. The method includes: preparing the mixed Sr18 biological nematocide from 8-time concentrated aqueous solution of Sr18 and avermectin emulsion according to a weight part ratio of 7.5:2; subjecting soil to rotary tillage before use of the mixed Sr18 biological nematocide, dividing plots according to areas of test plots, ridging, taking corresponding Sr18 agent and avermectin emulsion according to the preparation ratio at the step (1), uniformly mixing, adding clean water for diluting by 10-20 times, adopting spraying equipment for soil spraying, transplanting in 3-5 days after application of the mixed Sr18 biological nematocide, and additionally applying the nematocide for 1-2 times to long-season vegetables in the middle period of planting by irrigating the nematocide along with water and keeping the dosage and proportion unchanged; detecting conditions of vegetable root-knot nematodiasis. Experiment results show that root-knot nematodiasis can be effectively controlled by the method, consumption and utilization frequency of avermectins are greatly reduced, the picking period of cucumbers is greatly prolonged by about 3 months, and fruit setting rate of tomatoes is increased by 30%.

Veterinarian composition comprising an organic salt of levamisole in combination with at least one avermectine and / or milbemycine. A veterinarian formulation comprising of organics salts of levamisole, more specifically to the disophenolat salt of levamisole and the nitroxynil-salt of levamisole with avermectines and milbemycines and its use in treatment of helminthiasis in mammals, in particular in bovines, swines, caprines, equines, ovines, canines and felines.

The invention discloses an avermectin emulsion pesticide and a production technology thereof. The pesticide comprises 1-2 percent of avermectin emulsion, 6-10 percent of methyl nano, 1-3 percent of isophorone, 4-8 percent of phenethyl isopropyl phenyl phenol ethoxylates, 1-3 percent of calcium dodecyl benzene sulfonate and the balance of water according to percent by weight, and a preparation method comprises processes of weighing, dissolving raw medicines, preparing mother liquor and shearing. The avermectin emulsion pesticide has the advantages that dosage form is stable, synergism is obvious, and the production technology is simple.

The invention provides avermectin nanopowder and a preparation and use method thereof. The avermectin nanopowder is made from, by weight, 1-25% of avermectin / methamidoavermectin benzoate, 1-30% of a surfactant, 0.5-10% of a stabilizer, and 35-65% of a functional carrier. The functional carrier is a compound which contains at least one phenyl and one carboxylic group. The preparation method does not require high energy consumption equipment such as a grinder, the preparation process is simple and easy to control, the quality of products is stable, the reproducibility is good, the production efficiency and the utilization rate of pesticides are improved, and the production cost is saved. Due to the small size effect, the large specific surface effect, the interfacial effect and the high permeability characteristics of a nano preparation, the dispersity and dissolution rate of insoluble pesticides are easily improved, the bioavailability of the nano powder is improved, the consumption ofpesticides is reduced, and residual pollution is reduced.

The invention relates to a method used for increasing industrial avermectin B<1a> yield via optimization of fermentation medium. It is found via large scale of screening that adding of an appropriate concentration of calcium chloride into streptomyces avermitilis fermentation medium is capable of increasing B<1a> yield obviously. The invention also provides a medium used for the method.

The invention discloses a synergistic acaricidal composition containing avermectin and spiromesifen. The acaricidal composition comprises a first effective component, a second effective component and common auxiliary components, wherein the first effective component is the avermectin, the second effective component is the spiromesifen, and the weight ratio of the avermectin to the spiromesifen is 30:1-1:80. After being the compounded, the acaricidal composition has a significant synergistic effect. The effect of preventing the panonychus on the orange and the carminespider mite on the cotton of the acaricidal composition is superior to the effect of the single avermectin and the single spiromesifen. Due to the adoption of the acaricidal composition, the use amount of the pesticide can be reduced, the cost of the pesticide can be lowered, the pollution to the environment can be reduced.

The invention discloses a CAPS marking method for detecting avermectin resistance related gene mutation of spider mites. Spider mite population GluCl3 gene to be detected which contains a gene fragment with G326E mutation is amplified, and enzyme sites are analyzed, wherein a Hinf I enzyme site exists in the amplified fragments of the sensitive population, and the site does not exist in the resistance homozygosis population, amplified fragments containing the Hinf I enzyme site exist in the resistance heterozygosis population, and amplified fragments without the site exist in the resistance heterozygosis population. The method can be used for replacing traditional biological assay methods, and has the advantages of little manpower and few sample amounts, large detection quantity, high sensitivity, good specificity, rapid and simplicity, and accuracy and reliability; the method is suitable for rapid diagnosis of avermectin resistance of Tetranychus urticae field population, and is usedfor carrying out real time monitoring and early warning forecast of avermectin resistance of field spider mites at the same time; the method has important meaning for avermectin resistance monitoringof field spider mites, and application prospect is wide.

The invention discloses an insecticidal composition which comprises the constituents (by weight portions) of avermectin 0.2-5%, and thiazine ketone 5-40%, balancing adjuvant and dissolvent. The composition has synergic action and the action of delaying drug resistance.

The invention discloses a quick analysis method for a reaction process of emamectin benzoate and relates to an analysis method for a chemical reaction intermediate process. By utilizing the method, the problems that the time for high performance liquid chromatograph is long, the operation steps are minute and complicated, the detection is time-consuming, a large number of samples need to be measured, the provided experimental data often lags behind the production process, the monitoring of the production process is incomplete and problems can not be found in time are solved. The method comprises the following steps: 1) establishing a sample library; 2) establishing a sample spectral pattern library; 3) selecting a sample; 4) carrying out pretreatment on the sample; 5) establishing a standard sample model; 6) establishing a quantitative analysis model, and getting an optimal quantitative analysis model; and 7) collecting spectral information of the sample to be tested, and predicting the contents of residual avermectin B1a and double-protection matter in the sample to be tested through the optimal quantitative analysis model. The analysis of the sample can be completed within 1 minute by the method, thus the method is time-saving, labor-saving and cost-saving and is easy for operation.