14 results about "Avermectines" patented technology

Provided herein are compositions for the prevention and treatment of demodex blepharitis in a subject and processes of treatment or prevention of demodex blepharitis. The compositions may include at least one avermectin compound selected from 5-O-demethyl-22,23-dihydroavermectin A1a or 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a, or a combination thereof, and melatonin, wherein an aggregate concentration of the avermectin compound is optionally less than 1 wt %. Further devices are provided that include wipe including a woven or non-woven membrane and a treatment composition, the treatment composition including melatonin, one or more anti-microbial compounds, and optionally one or more pharmaceutically acceptable excipients and processes of treatment or prevention of demodex blepharitis in a subject using the wipe, alone or optionally further with the composition as provided herein.

This invention discloses a method for preparing avermectin nanoparticles supported on zein-sodium lignin sulfonate, and its applications. The preparation method involves dissolving avermectin and zein in an organic solvent to form a solution (stream 1), and dissolving sodium lignin sulfonate or modified sodium lignin sulfonate in deionized water to form a solution (stream 2). Both streams are simultaneously injected into a dual-channel confined counter-current mixer for rapid mixing. The resulting nanoparticle suspension is then collected, completing the preparation process. This invention utilizes the compatibility of hydrophobic zein with avermectin, combined with the self-assembly properties of zein and the use of sodium lignin sulfonate or modified sodium lignin sulfonate as a stabilizer, to prepare avermectin nanoparticles with high drug encapsulation efficiency and excellent drug release performance. Furthermore, these nanoparticles exhibit excellent resistance to UV photodegradation, effectively reducing the photodegradation of avermectin. The method is simple, rapid, and easy to control.

The invention discloses an abamectin fermentation culture medium and a fermentation process, and relates to the technical field of culture media. The abamectin fermentation culture medium is prepared from 15 g / L to 30 g / L of glucose, 81 g / L to 103 g / L of dextrin, 8 g / L to 12 g / L of corn steep liquor, 11 g / L to 15 g / L of soybean cake powder, 0.2 g / L to 0.5 g / L of ammonium sulfate, 0.2 g / L to 0.5 g / L of dipotassium phosphate, 0.05 g / L to 0.2 g / L of monopotassium phosphate, 0.05 g / L to 0.32 g / L of manganese sulfate, 0.3 g / L to 0.5 g / L of cobalt chloride, 0.6 g / L to 1.8 g / L of sodium chloride, 0.05 g / L to 0.25 g / L of a defoaming agent and 2.4 g / L to 5.2 g / L of silanization modified aluminum oxide. According to the technical scheme, glucose and dextrin are adopted as carbon sources, corn steep liquor, soybean cake powder and ammonium sulfate are adopted as nitrogen sources, and silanization modified aluminum oxide is added, so that the element production capacity of thalli is improved, and the titer of abamectin B1a is improved.

Palatable oral dosage formulations are provided including an effective amount of an isoxazoline parasiticidal agent, an avermectin, and a pyrazinoisoquinoline, and optionally one or more additional active ingredients, such as a tetrahydropyrimidine.

The invention belongs to the technical field of gene detection, and particularly relates to a tetranychus urticae cytochrome P450 gene and application thereof to detection and / or monitoring of avermectin resistance of tetranychus urticae. The CYP392A13 gene shows up-regulated expression in a tetranychus urticae resistant population, and the correlation between the target gene and the avermectin resistance of the tetranychus urticae is further confirmed from the back side and the front side through RNAi and in-vitro metabolic activity tests. Therefore, the specific primer pair, the primer group, the kit and the method for detecting the abamectin resistance of the tetranychus urticae are researched and developed, if the expression quantity of a target gene in a population to be detected is obviously higher than that of a tetranychus urticae sensitive population, the population to be detected has the abamectin resistance; a key molecular tool is provided for establishing an abamectin resistance early warning system, and a drug resistance treatment strategy can be formulated in time.

Palatable oral dosage formulations are provided including an effective amount of an isoxazoline parasiticidal agent, an avermectin, and a pyrazinoisoquinoline, and optionally one or more additional active ingredients, such as a tetrahydropyrimidine.

This application relates to the field of pesticide production technology, specifically disclosing a fermentation production process for avermectin and avermectin itself. The avermectin fermentation production process involves inoculating *Streptomyces avermectin* into a culture medium for fermentation. The fermentation process is divided into five stages: 0-20 hours for the adaptation period, 21-80 hours for the growth period, 81-250 hours for the stationary period, and 251-300 hours for the aging period. The aeration rate during the adaptation period is 2000-2500 L / h, during the growth period it is 3000-3200 L / h, during the stationary period it is 2200-2500 L / h, and during the aging period it is 1900-2100 L / h. This avermectin fermentation process can achieve an avermectin yield of 6.89-7.11 g / L, effectively increasing avermectin production. Furthermore, the flexible adjustment of the aeration rate can effectively reduce gas waste, conserve resources, and improve overall economic efficiency.

The application discloses a solid culture medium for fermenting avermectin by using agricultural wastes and an application thereof, and belongs to the technical field of microbial fermentation. In order to solve problems of large water resource and organic reagent consumption, high energy consumption, high cost, environmental unfriendliness and the like in the production of avermectin by using liquid fermentation, and to solve the problem of low utilization rate of agricultural wastes, the optimal agricultural wastes are screened as the solid fermentation culture medium of Streptomyces avermitilis, and the green solid fermentation strategy of Streptomyces avermitilis is developed by optimizing the solid fermentation culture medium of Streptomyces avermitilis and fermentation process parameters, so as to reduce the fermentation cost, reduce the waste of equipment energy consumption, water resource and the generation of waste water and waste residue, and to realize the application of avermectin at a lower cost and in a green and environmental-friendly manner.

The present invention relates to the technical field of rodent pest control. Disclosed are the use of avermectin and a rodenticide formulation. The avermectin has a structure represented by formula (I). The present invention uses a strategy of "new use for old drugs", uses commercially available pesticides as candidate compounds, and uses mouse thrombin as a target to single out pesticide avermectin strongly bound to thrombin, which can activate the activity of mouse thrombin and promote blood coagulation. The present invention has the advantages of low cost, good rodenticidal killing effect, acute and chronic efficacy, good palatability, easy degradation, and the like.

This invention discloses Toll Gene dsRNA and its application in enhancing the efficacy of avermectin in controlling citrus psyllids. This invention provides a targeted... DcToll A technical solution for controlling citrus psyllids using a combination of dsRNA and avermectin, specifically silencing the citrus psyllid's dsRNA. DcToll Inhibiting the immune response of citrus psyllids by targeting genes can reduce their potential tolerance to abamectin. The method provided by this invention holds promise for achieving a synergistic effect between immunosuppression and chemical agents, offering a new technical approach to improving the efficacy of abamectin and delaying the development of resistance, thus contributing to achieving reduced pesticide use and increased efficiency.

The invention relates to the technical field of pharmaceutical chemical purification, and discloses a multistage extraction and crystallization synthesis method in a refining process of acetamido abamectin, the composition comprises: a eutectic solvent formed by tetrabutylammonium bromide and L-menthol; a carboxyl functionalized molecular sieve as a targeted adsorbent; synergistic triggers as crystallization regulators. The core of the method provided by the invention is as follows: in the deep eutectic solvent, the steps of dissolving and extracting the crude acetamido abamectin and adsorbing and removing impurities by the carboxyl functionalized molecular sieve are integrated; after filtering, dropwise adding a synergistic triggering agent into clear filtrate at a constant speed, and inducing a target product to crystallize and separate out through dynamic interface regulation and control. According to the invention, a plurality of purification units are integrated in a one-kettle manner, the process flow is obviously simplified, key impurities are effectively removed through a dual purification mechanism, the product purity is high, the yield is good, and the process is green and environment-friendly.

The application relates to a detection method and a purification method of abamectin, the detection method comprising the following steps: step 1, adding methanol into abamectin fine products to prepare an abamectin methanol solution; step 2, placing the abamectin methanol solution in a volumetric flask and freezing at-18 to-20 DEG C for at least 16 hours; and step 3, placing distilled water in another equal-volume volumetric flask, comparing the frozen abamectin methanol solution with the distilled water under a film reading lamp, and judging the turbidity of the abamectin methanol solution; the purification method comprises the following steps: mixing the abamectin fine products with unqualified impurities determined through turbidity detection with distilled water, heating to boiling, then cooling to room temperature, centrifuging, drying the solid, and then performing turbidity detection again until the turbidity detection is qualified. The application can detect and remove impurities that can cause crop phytotoxicity, improve the quality of abamectin technical material, and make the abamectin technical material capable of being used for preparing emulsifiable concentrate preparations.

The invention discloses a method of a Xinjiang early yellow fig tissue culture and rapid propagation system, and belongs to the technical field of plant tissue culture. The method comprises the steps of explant selection and treatment, induction culture, subculture, rooting culture and domestication and transplanting. In the explant pretreatment, a bacitracin-ursolic acid-abamectin conjugate is used for disinfection, so that the bacitracin and abamectin cooperate to resist bacteria and prevent microbial infection, and ursolic acid is used for inhibiting the activity of polyphenol oxidase to prevent explant browning; hormone-enriched microspheres with chitosan as a core layer and calcium alginate-lignosulfonate as a shell layer are added into the culture medium, BA or NAA can be stably stored and accurately released, nutrient substances can also be adsorbed, meanwhile, mannitol, L-proline and betaine loaded on the microspheres can adjust osmotic pressure, enhance cell stress resistance and reduce vitrification, and the hormone-enriched culture medium is suitable for being used as a culture medium. The rapid propagation of the fig explant can be efficiently promoted, and a feasible technical path is provided for the tissue propagation of the fig explant.

The application provides a pesticide composition, a preparation method and application thereof, and belongs to the technical field of pesticides.The active ingredient of the pesticide composition is composed of acetylamino-avermectin B2a and fluopyram, and the weight ratio of the acetylamino-avermectin B2a and the fluopyram is 30:1-1:30;the preparation method is that acetylamino-avermectin B2a, fluopyram, wetting dispersant, thickening agent, antifreezing agent, defoaming agent and water are mixed according to a predetermined proportion, wet sand grinding is carried out, and water suspension concentrate with a particle size D90 of less than or equal to 5 microns is obtained;the pesticide composition is used for preventing and treating root nematodes of vegetables, cereals and flowers, and the application mode is hole application, trench application or root irrigation.The pesticide composition is high in efficiency, low in toxicity, friendly to the environment, and has a high social value.