Nano micro ball with taxol capable of biologically degradating high molecule and its preparing method
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
- Publication Date
- 2005-01-12
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to biodegradable macromolecular nano microspheres loaded with paclitaxel and a preparation method thereof. Background technique
[0002] Paclitaxel is a diterpene natural product, which was first isolated from the bark of Pacific yew tree and Taxus brevifolia by Wani et al. in 1971 (J.AM.Chem. Soc.), 93:2325 (1971)), and its structure was determined by chemical and X-ray crystallographic methods. It has been found to be effective in the treatment of various tumors, such as ovarian cancer, breast cancer, non-small cell lung cancer, head cancer and neck cancer.
[0003] The biological activity of paclitaxel is related to its effect on cell division. It can promote the assembly of microtubule dimers into microtubules during cell division, and then increase the stability of microtubules by preventing the multimerization process, thereby inhibiting the normalization of the microtubule network. Kinetic reorganization, thereby affectin...