Polystyrene/calcium alginate composite gel microsphere in nuclear shell structure and preparation method thereof

A technology of calcium alginate gel and polystyrene microspheres, which can be used in the preparation of microspheres, microcapsule preparations, medical preparations of non-active ingredients, etc., and can solve the problems of easy agglomeration, large size, and blockage of products. Achieve the effect of low production equipment requirements, controllable shell thickness, and mild synthesis conditions
CN101857698AInactive Publication Date: 2010-10-13XIAMEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2010-10-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a polystyrene / calcium alginate composite gel microsphere in a nuclear shell structure and a preparation method thereof, relating to biopolymer materials. The polystyrene / calcium alginate composite gel microsphere in the nuclear shell structure takes a polystyrene microsphere as a core and calcium alginate gel as a shell, wherein the grain size of the core is 1-100 microns, and the thickness of the shell layer is 50-800 nm. The preparation method comprises the following steps of: mixing polystyrene microsphere with aqueous solution containing a surface active agent I, and carrying out ultrasonic emulsification to obtain mixed solution A; adding sodium alga acid solution in the mixed solution A, and stirring to obtain mixed solution B; adding organic solution containing a surface active agent II into the mixed solution B, and stirring to obtain mixed solution C; adding calcium chloride solution which has the same volume with the sodium alga acid solution into the mixed solution C under stirring to react, and carrying out vacuum filtration, washing the solution until no calcium ion residue exists on the surface and drying to obtain a product D; and dispersing the product D into water, centrifuging the mixture, pouring out supernate and taking out precipitate to obtain the product.
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Description

technical field

[0001] The invention relates to a biopolymer material, especially a polystyrene / calcium alginate composite gel microsphere with a core-shell structure and a preparation method thereof. Background technique

[0002] Using natural or synthetic polymers with good biocompatibility as carriers of drugs, enzymes, cells or other bioactive molecules, and realizing intelligent controlled release, targeted delivery, artificial cells, etc. is one of the research hotspots in polymer science in recent years. . Calcium alginate gel is one of the most studied biogels due to its ease of preparation and good biocompatibility. High-stability core-shell structure polymer microcontainers are usually hollow microcapsules or microspheres, because different preparation methods have different lumens, shell structures, permeability properties and surface properties, which can realize the drug, enzyme, cell or other bioactive molecules for effective protection and controlled release...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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