Polystyrene/calcium alginate composite gel microsphere in nuclear shell structure and preparation method thereof

A technology of calcium alginate gel and polystyrene microspheres, which can be used in the preparation of microspheres, microcapsule preparations, medical preparations of non-active ingredients, etc., and can solve the problems of easy agglomeration, large size, and blockage of products. Achieve the effect of low production equipment requirements, controllable shell thickness, and mild synthesis conditions

Inactive Publication Date: 2010-10-13
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first method is the most commonly used, but generally the obtained balls are larger in size (greater than 1mm). To obtain smaller balls, special extruders are required, and such instruments are usually expensive and prone to clogging during use.
The second method can obtain micron-sized spheres, but due to the high viscosity of sodium alginate solution, the products obtained by the second method are easy to agglomerate, and it is difficult to obtain regular microspheres
At present, the construction of a single-component calcium alginate gel shell on the surface of polystyrene microspheres has not been reported

Method used

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  • Polystyrene/calcium alginate composite gel microsphere in nuclear shell structure and preparation method thereof
  • Polystyrene/calcium alginate composite gel microsphere in nuclear shell structure and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1: Mix 1g of polystyrene microspheres with 20mL at a concentration of 2.8×10 -2 Mix g / L Tween-60 aqueous solution, after ultrasonic emulsification for 1h, add 2mL sodium alginate solution with a concentration of 30g / L under the action of magnetic stirring, stir 40ml n-heptane solution with 0.036g Span-80 after stirring for 3h Pour into the above system, stir at room temperature for 2 hours, slowly add 2 mL of calcium chloride solution with a mass fraction of 10%, and react for 1 hour, then use a Buchner funnel to carry out suction filtration, and repeatedly rinse with distilled water until no calcium ions remain on the surface. Dry, disperse the obtained product into water, centrifuge at a speed of 3000r / min for 20min, pour out the supernatant, and take out the precipitate as the final product. From SEM photographs (see figure 1 ) It can be seen that the product has a core-shell structure, the white spherical matrix in the figure is polystyrene with a particle ...

Embodiment 2

[0025] Example 2: The steps are the same as in Example 1, but the concentration of the sodium alginate solution is changed to 50g / L, and finally polystyrene / calcium alginate composite gel microspheres with a core-shell structure can be obtained, and the shell thickness can reach 600nm.

Embodiment 3

[0026] Example 3: The steps are the same as in Example 1, but the concentration of the sodium alginate solution is changed to 10g / L, and finally polystyrene / calcium alginate composite gel microspheres with a core-shell structure can be obtained, and the shell thickness can reach 50nm.

[0027] Example 3: The steps are the same as in Example 1, but the amount of Span-80 is changed to 0.032g, so that the concentration is 0.8 times the critical micelle concentration, and finally a polystyrene / calcium alginate composite gel with a core-shell structure can be obtained The shell thickness of the microsphere is 300nm.

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Abstract

The invention provides a polystyrene/calcium alginate composite gel microsphere in a nuclear shell structure and a preparation method thereof, relating to biopolymer materials. The polystyrene/calcium alginate composite gel microsphere in the nuclear shell structure takes a polystyrene microsphere as a core and calcium alginate gel as a shell, wherein the grain size of the core is 1-100 microns, and the thickness of the shell layer is 50-800 nm. The preparation method comprises the following steps of: mixing polystyrene microsphere with aqueous solution containing a surface active agent I, and carrying out ultrasonic emulsification to obtain mixed solution A; adding sodium alga acid solution in the mixed solution A, and stirring to obtain mixed solution B; adding organic solution containing a surface active agent II into the mixed solution B, and stirring to obtain mixed solution C; adding calcium chloride solution which has the same volume with the sodium alga acid solution into the mixed solution C under stirring to react, and carrying out vacuum filtration, washing the solution until no calcium ion residue exists on the surface and drying to obtain a product D; and dispersing the product D into water, centrifuging the mixture, pouring out supernate and taking out precipitate to obtain the product.

Description

technical field [0001] The invention relates to a biopolymer material, especially a polystyrene / calcium alginate composite gel microsphere with a core-shell structure and a preparation method thereof. Background technique [0002] Using natural or synthetic polymers with good biocompatibility as carriers of drugs, enzymes, cells or other bioactive molecules, and realizing intelligent controlled release, targeted delivery, artificial cells, etc. is one of the research hotspots in polymer science in recent years. . Calcium alginate gel is one of the most studied biogels due to its ease of preparation and good biocompatibility. High-stability core-shell structure polymer microcontainers are usually hollow microcapsules or microspheres, because different preparation methods have different lumens, shell structures, permeability properties and surface properties, which can realize the drug, enzyme, cell or other bioactive molecules for effective protection and controlled release...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L25/06C08L5/04B01J13/02A61K47/36C12N11/10C12N11/04
Inventor 戴李宗蒋妮娜许一婷罗伟昂
Owner XIAMEN UNIV
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