Method for preparing nano liver-target biodegradating medicine carrier material

Abstract

The preparation method includes the following steps: modifying hepatic target compound onto degradable polymer (chitosan, polylysine, glucosan, agar, polyglutamic acid-benzyl ester, polyalanine) with biological compatibility, and adopting ion exchange or ultrasonic emulsification process to obtain the invented nano hepatic target bio-degradable medicine carrier material. The hepatic target nano particle solution has good target performance for liver, the medicine enriched rate in the liver can be up to 75%, and its slowly-released administration can be up to above 15 days.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, in particular to a method for preparing a nano liver-targeted biodegradation drug carrier material. Background technique

[0002] Liver cancer, especially primary liver cancer, is a common clinical disease and frequently-occurring disease. The mortality rate of primary liver cancer ranks third among malignant tumors, second only to gastric cancer and esophageal cancer. my country is an area with a high incidence of liver cancer, accounting for more than 50% of the global incidence. For the treatment of liver cancer, liver transplantation is the most recommended at present, but donors are hard to find. Anticancer drug therapy (cyclophosphamide, arabinothymidine hydrochloride) due to the systemic distribution of the drug, the drug concentration in the lesion is not high enough, but the damage to other organs is greater, and some patients often die from the damage of chemotherapy drugs to other...

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