Method for preparing nano liver-target biodegradating medicine carrier material

A carrier material and biodegradation technology, which is used in drug combinations, pharmaceutical formulations, medical preparations with non-active ingredients, etc., to achieve the effects of high sustained-release drug delivery, reduced treatment costs, and good targeting ability.

Inactive Publication Date: 2008-10-29
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The introduction of small molecular substances with high liver targeting properties such as glycyrrhetinic acid, glycyrrhizic acid, and bile acid into degradable and biocompatible polysaccharides and polyamino acids has not been reported yet.

Method used

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  • Method for preparing nano liver-target biodegradating medicine carrier material
  • Method for preparing nano liver-target biodegradating medicine carrier material
  • Method for preparing nano liver-target biodegradating medicine carrier material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1. Preparation of modified glycyrrhetic acid-modified chitosan nano-liver-targeted biodegradable drug carrier material and nanoparticles:

[0065] 1. Preparation of glycyrrhetic acid-modified chitosan:

[0066] Weigh 2 g of glycyrrhetic acid and 1 g of EDC into a 200 mL beaker, add 70 mL of DMF to the bottle, and dissolve with magnetic stirring.

[0067] Add 5g of chitosan into a 500mL three-necked bottle, add 100mL of distilled water and stir magnetically until dissolved. Then, pour the glycyrrhetic acid solution prepared above into the chitosan solution, continue stirring, and heat to 60° C. to react for 6 hours. The reaction solution was cooled to 40°C and concentrated to about 50 mL with a rotary evaporator. The concentrated solution was poured into a beaker containing 800 mL of ethanol for precipitation, filtered, and the precipitate was washed with 50 mL of ethanol and 50 mL of diethyl ether respectively, and dried in vacuum (40° C., 5 mmHg) for 24 hours...

Embodiment 2

[0074] Example 2. Preparation of modified glycyrrhetic acid-modified polylysine nano-liver-targeted biodegradable drug carrier material and nanoparticles:

[0075] 1. Preparation of glycyrrhetic acid-modified polylysine:

[0076] Weigh 2 g of glycyrrhetic acid and 1 g of EDC into a 200 mL beaker, add 70 mL of DMF to the bottle, and dissolve with magnetic stirring.

[0077] Add 5 g of polylysine to a 500 mL three-necked flask, add 100 mL of distilled water and magnetically stir until dissolved. Then, the glycyrrhetic acid solution prepared above was poured into the polylysine solution, continued stirring, and heated to 60° C. to react for 6 hours. The reaction solution was cooled to 40°C and concentrated to about 50 mL with a rotary evaporator. The concentrated solution was poured into a beaker containing 800 mL of ethanol for precipitation, filtered, and the precipitate was washed with 50 mL of ethanol and 50 mL of ether, and dried in vacuum (40° C., 5 mmHg) for 24 hours. Th...

Embodiment 3

[0084] Embodiment 3. Preparation of agar nano-liver-targeted biodegradable drug carrier material and drug-loaded nanoparticles modified with glycyrrhetic acid:

[0085] 1. Preparation of glycyrrhetinic acid modified agar:

[0086] Weigh 2 g of glycyrrhetic acid and 1 g of EDC into a 200 mL beaker, add 70 mL of DMF to the bottle, and dissolve with magnetic stirring.

[0087] Add 7g of agar into a 500mL three-necked flask, add 100mL DMF and magnetically stir until dissolved. Then, the glycyrrhetic acid solution prepared above was poured into the agar solution, continued to be stirred, and heated to 60° C. to react for 6 hours. The reaction solution was cooled to 40°C and concentrated to about 50 mL with a rotary evaporator. The concentrated solution was poured into a beaker containing 800 mL of ethanol for precipitation, filtered, and the precipitate was washed with 50 mL of ethanol and 50 mL of ether, and dried in vacuum (40° C., 5 mmHg) for 24 hours. The product contained 4%...

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Abstract

The preparation method includes the following steps: modifying hepatic target compound onto degradable polymer (chitosan, polylysine, glucosan, agar, polyglutamic acid-benzyl ester, polyalanine) with biological compatibility, and adopting ion exchange or ultrasonic emulsification process to obtain the invented nano hepatic target bio-degradable medicine carrier material. The hepatic target nano particle solution has good target performance for liver, the medicine enriched rate in the liver can be up to 75%, and its slowly-released administration can be up to above 15 days.

Description

technical field [0001] The invention relates to a biodegradable drug carrier material and the composition of drug-loaded nanoparticles and a preparation method thereof, in particular to the preparation of biodegradable drug carrier materials by modifying liver-targeting compounds on degradable and biocompatible polymers , and prepare liver-targeted drug-loaded nanoparticles by encapsulating the drug by ion crosslinking or phacoemulsification. Background technique [0002] Liver cancer, especially primary liver cancer, is a common and frequently-occurring disease in clinical practice. The mortality rate of primary liver cancer ranks third among malignant tumors, after gastric cancer and esophageal cancer. my country is a high-incidence area of ​​liver cancer, accounting for more than 50% of the global incidence. For the treatment of liver cancer, liver transplantation is currently the first recommendation, but donors are hard to find. Anticancer drug therapy (cyclophospham...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/30A61K47/48A61K31/704A61K31/575A61K31/56A61P35/00A61K47/61A61K47/64
Inventor 袁直查瑞涛杜田赵建新
Owner NANKAI UNIV
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