7 results about "Alcohol dependence" patented technology

The invention belongs to the technical field of medicines, and discloses a ligustrazine derivative modified based on a monosaccharide structural unit and a preparation method of the ligustrazine derivative. According to the invention, a monosaccharide structural unit is introduced to carry out glycosylation modification on ligustrazine molecules, so that the water solubility, the biological activity and the drug effect durability of ligustrazine are remarkably improved, and the pharmacological characteristics of ligustrazine are optimized; the glycosylation modification not only can improve the solubility and stability of ligustrazine, but also can improve the treatment effect of the ligustrazine in specific diseases (such as alcohol addiction and the like) by increasing the affinity of the ligustrazine to a specific target spot; through the technical scheme, the defects of the existing ligustrazine derivative in the aspects of bioavailability, drug effect persistence and the like can be overcome, and the treatment effect and clinical application value of the ligustrazine derivative are remarkably enhanced; the glycosylated and modified ligustrazine derivative has better targeting property and stability, is suitable for wider clinical treatment requirements, and particularly shows greater application potential in treatment of diseases such as alcohol dependence.

A system for detecting alcoholism using EEG signal processing, comprising: an EEG signal acquisition module configured to acquire digitized EEG signals from a plurality of electrodes placed on the scalp of a subject according to a 10-20 electrode placement system; a signal preprocessing module operationally connected to the EEG signal acquisition module and configured to preprocess the acquired digitized EEG signals, the preprocessed EEG signals being stored in a database containing signals from both alcohol-dependent and control subjects;a computing unit comprising at least one processor with dedicated memory, wherein the processor is configured to receive the preprocessed digitized EEG signals and perform a multi-resolution signal decomposition based on the discrete cosine harmonic wavelet packet transform (DCHWPT) to generate transformed signal representations corresponding to different frequency subbands; a feature extraction module connected to the computing unit and configured to extract a variety of features from the transformed signal representations; a feature selection module configured to perform a statistical test to reduce the dimensionality of the extracted features and retain only relevant features;a classification module configured to categorize EEG signals into an alcoholic or control category based on the retained relevant features; and an output module connected to the classification module, the output module comprising a user interface configured to display the classified results to the user.

The disclosure is directed to, in part, compounds, or pharmaceutically acceptable salts or solvates thereof, for modulating the activity of aldehyde dehydrogenase such as ALDH2 and / or methods for treating and / or preventing an alcohol related disorder such as alcohol use disorder, alcohol induced disorder, alcohol abuse, alcohol dependence, alcohol intoxication, alcohol withdrawal, and the like and / or methods for reducing the amount of alcohol consumed, reducing alcoholic cravings, or increasing the percentage of no heavy drinking days for a subject with alcohol use disorder.

The invention relates to the field of medical biology, in particular to a biological preparation for inhibiting the alcohol drinking amount of an alcohol-dependent person and application of the biological preparation. The invention discloses a biological agent for inhibiting the alcohol drinking amount of an alcohol-dependent person. The biological agent is lactobacillus plantarum extracellular vesicles. The lactobacillus plantarum extracellular vesicles play a role in regulating and controlling the drinking amount of alcohol-dependent rats by regulating the expression of the BNDF, the lactobacillus plantarum extracellular vesicles can increase the expression of the BDNF of PC12 cells in an in-vitro cell culture experiment, alcohol reduces the expression of the BDNF of the PC12 cells, and the lactobacillus plantarum extracellular vesicles achieve the inhibition effect by reversing the expression of the alcohol on the BDNF of the PC12 cells. According to the biological preparation for inhibiting the alcohol drinking amount of the alcohol-dependent person and the application of the biological preparation, SD male rats serve as research objects, the inhibiting effect of extracellular vesicles derived from intestinal lactobacillus plantarum on the alcohol drinking amount of the alcohol-dependent rats and related mechanisms are researched, and a new thought is provided for clinical prevention and treatment of alcohol dependence.

The application discloses a kind of pharmaceutical composition and its purposes in preparation for inhibiting the autonomous intake preference of ethanol. The pharmaceutical composition includes lorcaserin and midazolam. The pharmaceutical composition for inhibiting the autonomous intake preference of ethanol provided by the application can effectively reduce the desire of body to alcohol, is used to treat alcohol dependence, and has significant long-acting characteristics. When the pharmaceutical composition is administered to mice, the absolute amount of active ethanol intake of mice and the relative proportion of ethanol intake compared with the amount of drinking water can be significantly reduced, and the inhibitory effect can last at least 6 days, which is expected to update the treatment plan for alcohol addiction in clinic.

Provided herein is a method for weaning a subject suffering from a drug addiction or addictive behaviors involving opioid signaling by sequentially blocking peripheral and CNS opioid receptors and modulating opioid dependence.

Provided herein are (e.g., controlled release) compositions for the treatment of acute or chronic diseases or disorders. Described herein are processable opioid conjugates. Also described herein are compositions and methods for the treatment of central nervous system (CNS) diseases or disorders including chronic pain (e.g., cancer pain), acute pain, opioid addiction, alcohol addiction, alcohol dependence, opioid-induced constipation, and narcotic depression. Said compositions and methods comprise opioid agonists and / or opioid antagonists, which demonstrate CNS activity and / or other desirable activities. Injection of said compositions subcutaneously or intraspinally provides therapeutic benefit to individuals suffering from CNS diseases or disorders.