Method of treating epilepsy

An epileptic, eclamptic technique applied in the field of treating a subject's epilepsy and/or seizures that takes 15 to 40 minutes to resolve

Pending Publication Date: 2019-09-20
ALEXZA PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Onset of action may take 15 to 40 minutes and bioavailability of only 40% to 80% of the administered dose

Method used

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  • Method of treating epilepsy
  • Method of treating epilepsy
  • Method of treating epilepsy

Examples

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Embodiment 1

[0091] Example 1 evaluated the ability of inhaled alprazolam to rapidly suppress photosensitivity in a double-blind placebo-controlled crossover proof-of-concept study. This study was a clinically randomized placebo-controlled double-blind five-crossover study design that allowed for a small patient size. Evaluate patients with epilepsy using an intermittent photostimulation model to screen for antiepileptic effects without eliciting seizures or convulsive responses. Three doses of alprazolam and placebo (twice) were studied in 5 subjects.

[0092] In patients with photosensitive epilepsy, generalized epileptiform EEG activity was elicited using intermittent light stimulation. Subjects are exposed to a certain frequency of light stimuli (flash frequency) and a range of photosensitivity is measured. This model has been used to identify the antiepileptic effects of many drugs. The model is specific (sedative drugs do not show photosensitivity).

[0093] The main objectives o...

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Abstract

Alprazolam formulated as an inhaled condensation aerosol and method for treating epilepsy and / or seizures.

Description

[0001] Copyright Notice [0002] Portions of the disclosure of this patent document contain material that is protected by copyright. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure as it appears in the Patent and Trademark Office patent files or records, but otherwise reserves all copyrights. technical field [0003] The present invention relates generally to methods of treating epilepsy and / or seizures in a subject comprising administering by inhalation a therapeutic dose of alprazolam to said subject in need thereof. More specifically, the present invention relates to methods of treating epilepsy and / or seizures by administering alprazolam condensed aerosols. Background technique [0004] There are about 3 million people with epilepsy in the United States. There are two types of seizures: partial and generalized. Once diagnosed, patients are prescribed antiepileptic drugs (AEDs). If two AEDs f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573
CPCA61K31/5517A61P25/08A61K9/007A61K9/0075A61K9/0073A61K9/16
Inventor 詹姆斯·卡塞拉莉莉·恭埃德温·S·卡莫托
Owner ALEXZA PHARMA INC
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