4274 results about "Aerosol Solution" patented technology

The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.

The present invention relates to compositions for use in refrigeration, air-conditioning, and heat pump systems wherein the composition comprises a fluoroolefin and at least one other component. The compositions of the present invention are useful in processes for producing cooling or heat, as heat transfer fluids, foam blowing agents, aerosol propellants, and fire suppression and fire extinguishing agents.

A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a steroid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a steroid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.

A smoking article, such as a cigarette, comprises a lighting end and a mouth end. The smoking article possesses an aerosol-generation system that includes (i) a heat generation segment, and (ii) an aerosol-generating region or segment. A mouth end piece segment can be located at the mouth end of the smoking article. A segment of tobacco cut filler, gathered tobacco paper, or other type of flavor source material, can be positioned between the mouth end piece segment and the aerosol-generation segment. Optionally, segment composed of tobacco cut filler can be positioned so as to provide a lighting end segment. The smoking article possesses an overwrap (e.g., a single paper overwrap) that extends over the longitudinally extending surface of the mouth end piece segment, the aerosol generation segment, at least a portion of the length of the heat generation segment, any segment located between the mouth end piece and aerosol generation segments, and at least a portion of the length of the optional lighting end segment. Alternatively, the smoking article possesses an overwrap (e.g., a single paper overwrap) that extends over the longitudinally extending surface of the aerosol-generating segment, at least a portion of the length of the heat generation segment, at least a portion of any segment located downstream from the aerosol-generating segment, and at least a portion of the length of the optional lighting end segment, thereby forming a cigarette rod; and the cigarette rod is connected or attached to a filter element using a tipping type of material and arrangement.

A filter arrangement includes a tubular first filter element having a first media pack defining a first open filter interior and an air flow outlet. The air flow outlet is in gas flow communication with the first open filter interior. A housing construction has a gas flow inlet and a gas flow outlet. The air flow outlet of the first filter element is in gas flow communication with the gas flow outlet. A coalescer filter element is oriented in the housing construction in fluid communication with the gas flow inlet. A tubular second filter element is oriented in the housing construction and has a second media pack defining a second open filter interior. The second open filter interior is in gas flow communication with the gas flow outlet.

A pneumatic nebulizer that produces a high volume of aerosols for inhalent delivery of medications and other constituencies. High pressure gas formed into a gas jet is passed through a thin choked region of fluid that is entrailed and impinged upon an aerosol amplifier which creates a spray whose aerosol components are directed up through vents to an aerosol outlet for delivery. Larger-sized liquid particles are caused to pool up in a region surrounding the aerosol amplifer and then drip down back into the liquid medication reservoir.

A vented vial adapter for reconstitution of a medicament in a vial includes a vent lumen and a medicament lumen. The vent lumen has a cross-sectional area equal to or greater than that of the medicament lumen so that the fluid flow rate through the vent lumen is equal to or greater than that of the medicament lumen. As a result aerosols of the medicament outside the adapter are avoided as is the withdrawal of air bubbles from the vial as the reconstituted medicament is withdrawn from the vial. To maintain the diameter of the sharpened cannula of the vial adapter as small as possible, the vent lumen includes a concave wall facing the medicament lumen and a convex outer wall. In one embodiment, the vent lumen is in the shape of a polygon.

The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water emulsion composition includes: an oil globule system, selected from the group consisting of oil bodies; and sub-micron oil globules, about 0.1% to about 5% by weight of an agent, selected from the group consisting of a surface-active agent, having an HLB value between 9 and 16; and a polymeric agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.

An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

An arrangement for separating a hydrophobic liquid phase from a gaseous stream includes a coalescer filter, a housing, a gas flow direction arrangement, and a liquid collection arrangement. The coalescer filter includes a non-woven media of fibers. The housing includes an interior having a gas flow inlet and a gas flow outlet. The liquid collection arrangement is positioned within the housing construction and is oriented for receiving liquid collected from the coalescer filter and drained therefrom.

Electrocatalyst powders and methods for producing electrocatalyst powders, such as carbon composite electrocatalyst powders. The powders have a well-controlled microstructure and morphology. The method includes forming the particles from an aerosol of precursors by heating the aerosol to a relatively low temperature, such as not greater than about 400° C.

A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.

Crankcase ventilation arrangements are shown. Preferred wet laid media materials, for use in such arrangements are described. Also described and shown are example crankcase ventilation components, parts for use with a preferred media described and characterized.

The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a method aspect of the present invention, a drug ester is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a drug ester, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug ester degradation product. In a kit aspect of the present invention, a kit for delivering a drug ester through an inhalation route is provided which comprises: a) a thin coating of a drug ester composition and b) a device for dispensing said thin coating as a condensation aerosol.

The invention relates to an inhaler component for producing a steam / air mixture or / and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner. The inhaler component comprises the following elements: a housing (3); a chamber (21) arranged in the housing (3); an air inlet opening (26) for the supply of air from the surroundings to the chamber (21); an electrical heating element for evaporating a portion of a liquid material(16), the steam produced mixing in the chamber (21) with the air supplied through the air inlet opening (26), thereby producing the steam / air mixture or / and condensation aerosol; and a wick having a capillary structure, which wick forms a composite structure (22) with the heating element and automatically supplies the heating element with fresh liquid material (16) after evaporation. In order to provide the high specific evaporative capacity required for an intermittent, inhalation- or pull-synchronous operation of the inhaler component (2) while guaranteeing a high efficiency of the evaporator, the composite structure (22) is a flat structure and at least one heated section of the composite structure (22) is arranged in the chamber (21) in a contact-free manner, and the capillary structure of the wick is substantially exposed in the section on at least one side (24) of the flat composite structure.

Aerosol formulations suitable for use in pressurised metered dose inhalers comprise a hydrofluoroalkane propellant, an medicament for inhalation and a surfactant which is a a C8–C16 fatty acid or salt thereof, a bile salt, a phospholipid, or an alkyl saccharide.

A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.

A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and / or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

The lifetime of aerosol monitoring, concentration and collection equipment is extended by acoustic cleaning of accreted particle deposits from internal surfaces where fouling occurs by application of acoustic energy to the particle accretion surface, optionally in combination with a liquid wash or sampling volume. In one application, acoustic cleaning or sampling of particle deposits for analysis is triggered by a signal indicating changes in gas flow associated with particle loading. In another application, electro-acoustic transducers may be used to prevent particle buildup without interruption of particle monitoring.

A non-burning type flavor inhaler includes an aerosol source that generates an aerosol; an atomizer that atomizes the aerosol source without burning; a power source that supplies power to the atomizer; a light-emitting element; and a control unit that controls the light-emitting element. The control unit controls the light-emitting element in a first light-emitting mode in a puff state inhaling the aerosol, and controls the light-emitting element in a second light-emitting mode different from the first light-emitting mode in a non-puff state not inhaling the aerosol. The second light-emitting mode changes according to a number of puff actions for inhaling the aerosol.

A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible aerosolization catheter that can be manipulated during use, a device for the introduction of the aerosolization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller in communication with the medication delivery apparatus, gas delivery apparatus, and gas pressure relief apparatus control of the various means. The method includes providing insufflation gas and an aerosol of medication to an organ or body cavity while controlling overall pressure in the organ or cavity. The method may also include re-entering a patient through at least one port to apply gas and an aerosolized medicament, in either a post-operative procedure or in a chemotherapy context.

An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.

A continuous high-frequency oscillation breathing device delivers therapy during both inhalation and exhalation in order to assist in clearing secretions from the lungs. A fixed shrouded-venturi patient interface circuit is combined with medicated aerosol to deliver continuous high-frequency oscillation therapy. Fixed open apertures in the patient interface circuit allow ingress and egress of flow, and are calibrated to allow exhalation and prevent stacking of successive breaths.

An aerosol generator includes a flow passage having an inlet end, an outlet end, and a constriction in the flow passage at the outlet end. A heater is operable to heat liquid in the flow passage to produce a vapor, which is expelled from the outlet end of the flow passage.

A smoking device for aerosol-generation may comprise a device housing, a surface acoustic wave-atomizer (SAW-atomizer), a supply element, and a control system. The device housing may include a storage portion for an aerosol-forming substrate. The SAW-atomizer may include an atomization region, a first transducer, and / or a second transducer. The first transducer is configured to generate first surface acoustic waves that propagate along a surface of the SAW-atomizer. The supply element is arranged to supply the aerosol-forming substrate from the storage portion to the atomization region of the SAW-atomizer. The control system is configured to operate the SAW-atomizer to atomize the aerosol-forming substrate in the atomization region to generate an aerosol. A cartridge for such a smoking device and a method for generating an aerosol in a smoking system are also provided.

The use of pentafluoropropene (HFO-1225) and tetrafluoropropene (HFO-1234) in refrigeration equipment is disclosed. These materials are generally useful as refrigerants for heating and cooling, as blowing agents, as aerosol propellants, as solvent composition, and as fire extinguishing and suppressing agents.

Aluminum and aluminum-zirconium antiperspirant compositions comprising basic aluminum chlorides that have a particular molecular size distribution defined by having an SEC-HPLC Band III / II ratio of at least 0.5, having SEC-HPLC Band III plus Band II area of at least 70% of the total area and having SEC-HPLC Band I content no more than 5% and containing betaine (trimethylglycine), calcium and / or strontium are disclosed. Also disclosed are the methods of making these compositions and the use thereof in consumer acceptable antiperspirant vehicles such as aerosols, gels, roll-on, sticks and soft solids.

Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.