Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof

An alprazolam, anti-inflammatory and analgesic technology, which is applied in the field of alprazolam pharmaceutical composition, can solve the problems that have not yet been reported on alprazolam, and achieve improved anti-inflammatory and analgesic effects, significant progress, outstanding The effect of material characteristics

Inactive Publication Date: 2016-07-27
李晨露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no relevant report on alprazolam and its pharmaceutical composition and anti-inflammatory analgesia

Method used

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  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof
  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof
  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0017] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0018] Separation method: (a) Grind the dried rhizome (5kg) of Achyranthes sichuanensis, extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate to no alcohol smell (4L), and then use petroleum ether ( 4L×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) The n-butanol extract in step (a) is removed with AB-8 macroporous resin, first eluted with 8% ethanol for 10 column volumes, then with 70% ethanol for 12 column volumes, and collected 70% of ...

Embodiment 2

[0022] Embodiment 2: Anti-inflammatory and analgesic effects

[0023] 1. Materials and methods

[0024] 1.1 Drugs and reagents

[0025] Alprazolam was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Aspirin enteric-coated tablets (Jinan Yongning Pharmaceutical Co., Ltd.), Tween 80 (Tianjin Guangcheng Chemical Reagent Co., Ltd.); xylene (Tianjin Botong Chemical Co., Ltd.); Evans Blue (Sinopharm Chemical Reagent Co., Ltd.).

[0026] 1.2 Animals

[0027] Kunming mice, weighing 18-22 g, half male and half male, clean grade, provided by the Experimental Animal Center of Taishan Medical College.

[0028] 1.3 Analgesic experiment: mouse writhing method

[0029] Take 50 mice, half male and half female, weighing 18-22 g, and randomly divide them into alprazolam group (0.2 g·kg -1 ), compound (Ⅰ) group (0.2g·kg -1 ), alprazolam and compound (Ⅰ) composition group ...

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PUM

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Abstract

The invention discloses an alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof. The alprazolam pharmaceutical composition contains alprazolam and a natural product compound (I) which is separated and obtained from dry rhizomes of cyathula officinalis kuan and is novel in structure; when alprazolam and the natural product act separately, the anti-inflammatory and analgesic effects are common; when alprazolam and the natural product act jointly, the anti-inflammatory and analgesic effects are significantly improved, and alprazolam and the natural product can be developed into a drug capable of achieving the anti-inflammatory and analgesic effects. Compared with the prior art, the alprazolam pharmaceutical composition has the prominent substantive advantage and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of alprazolam, in particular to a pharmaceutical composition of alprazolam and its anti-inflammatory and analgesic effects. Background technique [0002] Alprazolam is a new BDZ drug with similar pharmacological effects to diazepam, such as anxiolytic, antidepressant, sedative, hypnotic, anticonvulsant and muscle relaxants. Its anti-anxiety effect is 10 times stronger than that of diazepam, and its mechanism of action may be related to the β-adrenoceptor in the brain. This product is absorbed quickly and completely after oral administration, and the peak plasma concentration can be reached in 1 to 2 hours. The plasma half-life is 12 to 18 hours, and the plasma concentration reaches a steady state in 2 to 3 days. Plasma protein binding is about 80%. After absorption, it is distributed throughout the body and can pass through the placental barrier. There are also drugs i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/22A61K31/5517A61K31/439A61P29/00
CPCC07D491/22A61K31/439A61K31/5517
Inventor 李晨露
Owner 李晨露
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