Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof

An alprazolam, anti-inflammatory and analgesic technology, which is applied in the field of alprazolam pharmaceutical composition, can solve the problems that have not yet been reported on alprazolam, and achieve improved anti-inflammatory and analgesic effects, significant progress, outstanding The effect of material characteristics

Inactive Publication Date: 2016-07-27
李晨露
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no relevant report on alprazolam and its pharmaceutical composition and anti-inflammatory analgesia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof
  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof
  • Alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0017] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0018] Separation method: (a) Grind the dried rhizome (5kg) of Achyranthes sichuanensis, extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate to no alcohol smell (4L), and then use petroleum ether ( 4L×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) The n-butanol extract in step (a) is removed with AB-8 macroporous resin, first eluted with 8% ethanol for 10 column volumes, then with 70% ethanol for 12 column volumes, and collected 70% of ...

Embodiment 2

[0022] Embodiment 2: Anti-inflammatory and analgesic effects

[0023] 1. Materials and methods

[0024] 1.1 Drugs and reagents

[0025] Alprazolam was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Aspirin enteric-coated tablets (Jinan Yongning Pharmaceutical Co., Ltd.), Tween 80 (Tianjin Guangcheng Chemical Reagent Co., Ltd.); xylene (Tianjin Botong Chemical Co., Ltd.); Evans Blue (Sinopharm Chemical Reagent Co., Ltd.).

[0026] 1.2 Animals

[0027] Kunming mice, weighing 18-22 g, half male and half male, clean grade, provided by the Experimental Animal Center of Taishan Medical College.

[0028] 1.3 Analgesic experiment: mouse writhing method

[0029] Take 50 mice, half male and half female, weighing 18-22 g, and randomly divide them into alprazolam group (0.2 g·kg -1 ), compound (Ⅰ) group (0.2g·kg -1 ), alprazolam and compound (Ⅰ) composition group ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an alprazolam pharmaceutical composition and anti-inflammatory and analgesic effects thereof. The alprazolam pharmaceutical composition contains alprazolam and a natural product compound (I) which is separated and obtained from dry rhizomes of cyathula officinalis kuan and is novel in structure; when alprazolam and the natural product act separately, the anti-inflammatory and analgesic effects are common; when alprazolam and the natural product act jointly, the anti-inflammatory and analgesic effects are significantly improved, and alprazolam and the natural product can be developed into a drug capable of achieving the anti-inflammatory and analgesic effects. Compared with the prior art, the alprazolam pharmaceutical composition has the prominent substantive advantage and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of alprazolam, in particular to a pharmaceutical composition of alprazolam and its anti-inflammatory and analgesic effects. Background technique [0002] Alprazolam is a new BDZ drug with similar pharmacological effects to diazepam, such as anxiolytic, antidepressant, sedative, hypnotic, anticonvulsant and muscle relaxants. Its anti-anxiety effect is 10 times stronger than that of diazepam, and its mechanism of action may be related to the β-adrenoceptor in the brain. This product is absorbed quickly and completely after oral administration, and the peak plasma concentration can be reached in 1 to 2 hours. The plasma half-life is 12 to 18 hours, and the plasma concentration reaches a steady state in 2 to 3 days. Plasma protein binding is about 80%. After absorption, it is distributed throughout the body and can pass through the placental barrier. There are also drugs i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/22A61K31/5517A61K31/439A61P29/00
CPCC07D491/22A61K31/439A61K31/5517
Inventor 李晨露
Owner 李晨露
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com