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Compound Nanxing pain paste and cataplasm combination and its preparation method

A composition, the technology of Nanxing, which is applied in the preparation of traditional Chinese medicine compositions and the field of compound Nanxing pain-relieving ointment cataplasm composition, can solve the problems of increasing the dosage of external application, contaminating the skin and clothing with oily matrix, reducing the clinical allergy rate, etc. , to achieve the effect of increasing the dosage of external use, strong transdermal effect, and strengthening the effect of drug treatment.

Active Publication Date: 2011-04-13
JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to improve the existing compound Nanxing analgesic ointment pharmaceutical composition, to provide a new compound Nanxing analgesic ointment composition, the drug inclusion capacity of the composition will be doubled Increase, in order to increase the amount of external administration; and improve the penetration of the skin layer, strengthen the drug treatment effect; will also greatly reduce the irritation of the drug, significantly reduce the clinical allergy rate, eliminate severe allergic reactions; and at the same time solve the plaster problems with sticking viscosity and contamination of skin and clothing with an oily base

Method used

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  • Compound Nanxing pain paste and cataplasm combination and its preparation method
  • Compound Nanxing pain paste and cataplasm combination and its preparation method
  • Compound Nanxing pain paste and cataplasm combination and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0230] Embodiment 1, the component and the weight of every 1000 cataplasma ointment raw materials are as follows:

[0231] Prepare materials according to the above ratio respectively, and the preparation steps are as follows:

[0232] Araceae, Chuanwu, Baizhi, Chuanxiong, cinnamon, asarum, clove, Xu Changqing, frankincense, myrrh and ten herbs were extracted with 6 times the amount of 85% ethanol for 2 times, each time for 1.5 hours;

[0233] Filtrate the reflux liquid, combine the filtrates, recover ethanol until the density of the extract is about 1.05-1.15, and set aside;

[0234] Camphor and borneol are pulverized, sieved, and set aside;

[0235] Add glycol to glycerin, mix thoroughly, add the above extract, EDTA, crospovidone, azone, propylene glycol, camphor, borneol, methyl salicylate, and continue stirring;

[0236] Put in NP-700 and stir evenly;

[0237] Dissolve tartaric acid and gelatin in purified water, put them into the glycerin phase, and continuously vacuum ...

Embodiment 2

[0239] Embodiment 2 is basically the same as Embodiment 1, but has the following changes:

[0240] The composition and weight of every 1000 cataplasm ointment raw materials are as follows:

[0241] Raw Araceae 275g Raw Chuanwu 210g

[0242] Cloves 175g Cinnamon 175g

[0243] Angelica dahurica 315g Asarum 130g

[0244] Chuanxiong 210g Xu Changqing 130g

[0245] Frankincense 86g Myrrh 86g

[0246] Camphor 66g borneol 66g;

[0247] Simultaneously, the component and weight of this composition auxiliary material are as follows:

[0248] NP-700 1.6kg Aluminum Glycol 65g

[0249] Tartaric acid 65g EDTA 18g

[0250] Glycerin 6.5kg Crospovidone 374g

[0251] Purified water 12kg Gelatin 110g

[0252] Azone 110g Propylene Glycol 210g

[0253] Methyl Salicylate 170g.

Embodiment 3

[0254] Embodiment 3 is basically the same as Embodiment 1, but has the following changes:

[0255] The composition and weight of every 1000 cataplasm ointment raw materials are as follows:

[0256] Raw Araceae 260g Raw Chuanwu 190g

[0257] Cloves 160g Cinnamon 160g

[0258] Angelica dahurica 285g Asarum 120g

[0259] Chuanxiong 190g Xu Changqing 120g

[0260] Frankincense 80g Myrrh 80g

[0261] Camphor 60g borneol 60g;

[0262] Simultaneously, the component and weight of this composition auxiliary material are as follows:

[0263] NP-700 1.4kg Aluminum Glycol 55g

[0264] Tartaric acid 55g EDTA 12g

[0265] Glycerin 5.5kg Crospovidone 350g

[0266] Purified water 10kg Gelatin 90g

[0267] Azone 90g Propylene Glycol 190g

[0268] Methyl Salicylate 150g.

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Abstract

The invention provides Nanxing Compound Pain Paste Cataplasma Combination, which is prepared from the following by the following weight parts: 267 grams of raw arisaema tuber, 200 grams of radix aconiti, 167 grams of cloven, 167 grams of cinnamon, 300 grams of angelica, 1250 grams of asarum, 200 grams of hemlock parsley, 125 grams of panicled swallowwort root, 83 grams of frankincense, 83 grams of myrrh, and 63 grams of borneol. The auxiliary materials used for preparing Nanxing Compound Pain Paste Cataplasma Combination are as follows by the following weight parts: 1.5kg of Np-700, 60 grams of dihydroxyaluminium aminoacetate, 60 grams of tartaric acid, 15 grams of EDTA, 6kg of glycerol, 362 grams of crosslinking polyvingypyrrolidone, 11kg of purified water, 100 grams of gelatin, 100 grams of azone, 200 grams of propylene glycol, 160 grams of methyl salicylate. By adopting the materials, 1000 pieces of cataplasma herb paste are prepared. The camphor and the borneol are in powder shape. Other medicaments ethanol extracts. The invention further provides a method used for preparing the combination. Nanxing Compound Pain Paste Cataplasma Combination carries large dosage, conserves water, preserves moisture, has excellent air permeability and skin permeability, can be removed and attached repetitively without such side effects as irritability and so on.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a compound Nanxing Zhitong ointment cataplasm composition and a preparation method of the traditional Chinese medicine composition. Background technique [0002] Pain relief plaster for external use is a commonly used drug. According to the survey, the incidence rate of joint and muscle pain is relatively high, which has seriously affected people's work and study. Although there are many oral and injected Chinese and Western medicines for the treatment of such diseases, most of them have side effects in varying degrees. Pain remains the easiest and most popular method. At present, topical plasters occupy an increasing market share. Wherein, except traditional black plaster, the application adhesive plaster (rubber plaster) is a kind of dosage form that uses a lot. For example, Compound Nanxing Zhitong Ointment (pharmaceutical composition) is a Class III new drug of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8884A61K31/045A61P29/00A61K31/125A61K9/70A61K47/42
Inventor 夏月殷书梅李吉峰王宓林新艳
Owner JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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