56 results about "Acute arthropathy" patented technology

A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and / or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion. An interspinous process implant with a selectably expandable spacer can be placed between adjacent spinous processes. a device implanted between the spinous processes of adjacent vertebrae of the spine can be used for relieving pain associated with the vertebrae and surrounding tissues and structures by maintaining and / or adding distraction between adjacent vertebrae. A tissue expander can be adapted to move from a first insertion position, for ease of implantation between spinous processes, to a second retention position that prevents displacement of the implant. An embodiment of a system can include an implant having a spacer with a thickness and a wing, wherein a first configuration of the wing has a first height substantially similar to the thickness and wherein the wing is adapted to be selectably arranged in a second configuration such that the wing has a second height greater than the first height. A periphery of the implant has a shape generally conformal with a shape of an inner surface of a cannula and a cross-sectional diameter smaller than an inner diameter of the cannula. The cannula is inserted such that a proximal end of the cannula is arranged between the adjacent spinous processes. The implant is then urged into position between the adjacent spinous processes by way of the cannula, and subsequently arranged in a second configuration to fix the implant in position.

The present invention provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

The invention is directed to a compound of the formula Iwherein the variables are as defined herein, ora stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof.Another aspect of the present invention is directed to a pharmaceutical composition comprising, a pharmaceutically effective amount of one or more compounds of formula I according to claim 1 in admixture with a pharmaceutically acceptable carrier.The invention is also directed to a method for effecting the prophylaxis and therapy of degenerative joint diseases such as osteoarthroses, spondyloses, cartilage loss following joint trauma or a relatively long period of joint immobilization following meniscus or patella injuries or ligament ruptures, diseases of the connective tissue such as collagenoses, periodontal diseases, wound healing disturbances and chronic diseases of the locomotory apparatus such as inflammatory, immunological or metabolism-associated acute and chronic arthritides, arthropathies, myalgias and disturbances of bone metabolism, for the treatment of ulceration, atheroscleroses and stenoses, and for the treatment of inflammations, cancer diseases, tumor metastasis formation, cachexia, anorexia, cardiac insufficiency and septic shock or for the prophylaxis of myocardial and cerebral infarctions, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound of formula I according to claim 1, or a pharmaceutically acceptable salt, solvate or prodrug thereof.Furthermore the invention is directed to a method for preparing a compound of formula I.

The invention provides a nanometer composition of chondroitin sulfate for external use and its preparation method and application, which belong to the field of medicine. The nano composition provided by the invention comprises the following components in mass percentage: 5-100% of nano drug system, 5-40% of moisturizing agent and 10-90% of drug carrier, and the sum of the amounts of each component is 100%. The nano-composition prepared by using a specific amount of each component raw material in the present invention has a structure similar to a biofilm, including an oil phase and a water phase, which is similar to the bilayer structure of the skin. According to the principle of similar miscibility, the present invention provides The nano composition can soften the cuticle of the skin, quickly penetrate the cuticle and subcutaneous tissue of the skin surface, enter the joint cavity, be directly absorbed at the bone joint, and maintain the drug concentration required for treatment in the joint cavity for a long time to treat joint diseases. Relieve pain and joint discomfort, convenient administration, no skin irritation, no discomfort.

The combined Chinese medicine for preventing and treating rheumatism, rheumatoid, protrusion of lumbar intervertebral disc, hyperosteogeny, spinal arthropathy and sciatica includes oral liquid and medicinal wine prepared with honey, date, eucommia bark, scorpion and other Chinese medicinal materials; granule, bolus and capsule prepared with vomiting nut, dragon's blood, edible fungus and other Chinese medicinal materials etc; and liniment prepared with vomiting nut, frankincense, myrrh and other three kinds of Chinese medicinal materials. The orally taken medicine and the externally applied medicine are used simultaneously to result in the synergistic functions of dispersing wind and cold, eliminating wetness and heat, dredging meridian passage, promoting blood circulation to disperse blood clots, diminishing inflammation and relieving pain.