7 results about "Acute arthropathy" patented technology

The utility model provides a lumbar zygapophyseal joint gasket, and relates to the technical field of lumbar zygapophyseal joint lesion treatment, the lumbar zygapophyseal joint gasket comprises a gasket main body, the gasket main body comprises a first contact wall, a second contact wall and a side wall; the edge contour of the first contact wall comprises two arc-shaped parts, the two arc-shaped parts are in smooth transition connection, and one arc-shaped part is larger in size and fuller than the other arc-shaped part; and the middle part of the first contact wall protrudes outwards to form an arc-shaped bulge. After the lumbar zygopophysis joint gasket is implanted and fixed between an upper zygopophysis and a lower zygopophysis, the edge contour of the first contact wall and the design of the arc-shaped protrusion can increase the contact area with the upper zygopophysis, and stability is improved; meanwhile, the gap height between the upper zygopophysis and the lower zygopophysis can be kept due to the existence of the lumbar zygopophysis joint gasket, inflammation and nerve compression caused by abnormal contact or displacement between the zygopophysis are avoided, therefore, clinical symptoms of the patient are relieved, and the life quality of the patient is improved.

The present invention relates to compositions comprising a mixture comprising or, alternatively, consisting of a turmeric extract and at least one compound selected from the group comprising or, alternatively, consisting of cinnamon oil and thymol for use in the treatment, preventive and / or curative, of at least one joint pathology of an inflammatory and / or degenerative nature and / or of a symptom associated therewith in human beings, or monogastric animals, by modulation of the receptors and / or enzymes of the endocannabinoid system.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

The invention relates to the technical field of image processing, in particular to a method for automatically identifying arthropathy in a sports medical image, which comprises the following steps of: acquiring the sports medical image and acquiring an edge in the sports medical image; according to the distribution positions of pixel points on the edges in the motion medical image, the possibility that end points in different disconnected edges are located on the same skeleton edge is obtained, and the disconnected edges are connected according to the possibility to obtain a complete skeleton edge; obtaining a plurality of joint gaps according to the distribution of pixel points in the complete skeleton edge; and according to the width of each position in the same joint gap and the width difference of different joint gaps, obtaining the lesion characteristics of the joint gaps and lesion joints. According to the method, the extension trend of the skeleton is analyzed, the incomplete skeleton edges are connected into the complete skeleton edge, and the joint position in the motion medical image is accurately obtained by further analyzing the characteristics of the joint edges, so that the diseased joint is accurately detected and recognized.

The invention discloses a triptolide-loaded engineered M2 macrophage exosome drug delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. A carrier of the delivery system is an M2 type macrophage source exosome combined and modified by phospholipid polyethylene glycol glucose; a loaded drug is triptolide, the triptolide is subjected to nano-micelle phospholipid polyethylene glycol glucose surface modification to form hypoxia response nanoparticles, M2Exo can target an inflammatory environment induced by macrophages, the specific anti-inflammatory biological function of M2Exo can be played, and the hypoxia response nanoparticles can be used for preparing the anti-inflammatory drug. Under the hypoxia condition, the compound is specifically taken by M1 macrophages, the polarization level and inflammatory response of the compound are inhibited, and the drug delivery efficiency is remarkably improved. Animal experiment model verification shows that the system can regulate and control rheumatoid arthritis synovial inflammation by regulating the polarization level of macrophages and improve the condition of arthropathy. According to the scheme, a new technical scheme is provided for precise treatment of inflammatory lesions such as rheumatoid arthritis caused by macrophages.

The invention relates to the technical field of biological medicines, in particular to a psoralen derivative and application thereof in preparation of a medicine for treating rheumatoid arthritis. According to the derivative, through an ester prodrug strategy, psoralen C8 / C5 hydroxyl and a non-steroidal anti-inflammatory drug are coupled to obtain a double-pharmacophore molecule. According to the invention, the problems of poor lipid solubility and high hepatotoxicity of psoralen are solved through an ester prodrug design strategy, a high-efficiency and low-toxicity novel drug candidate is provided for RA treatment, and the prepared psoralen derivative can effectively treat rheumatoid arthritis and complications thereof, and can significantly improve arthropathy caused by RA.

The invention belongs to the technical field of medicines, particularly relates to application of eupatilin in treatment of synovial arthropathy (such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and the like) and other joint diseases characterized by synovial pathology hyperplasia, and provides novel application of eupatilin in preparation of medicines for resisting synovial arthropathy. Particularly, the compound has a good inhibition effect on abnormal behaviors such as proliferation and invasion of synovial fibroblasts; eupatilin is provided as an effective medicine component for treating joint deformation, and the main action mechanism is that clinical symptoms are relieved by inhibiting proliferation and invasion of RA-FLS; the innovation of the invention lies in providing a therapy based on eupatilin, and through application of a specific dosage, joint inflammation of patients can be effectively relieved and joint functions can be improved.