4 results about "Acute arthropathy" patented technology

The utility model provides a lumbar zygapophyseal joint gasket, and relates to the technical field of lumbar zygapophyseal joint lesion treatment, the lumbar zygapophyseal joint gasket comprises a gasket main body, the gasket main body comprises a first contact wall, a second contact wall and a side wall; the edge contour of the first contact wall comprises two arc-shaped parts, the two arc-shaped parts are in smooth transition connection, and one arc-shaped part is larger in size and fuller than the other arc-shaped part; and the middle part of the first contact wall protrudes outwards to form an arc-shaped bulge. After the lumbar zygopophysis joint gasket is implanted and fixed between an upper zygopophysis and a lower zygopophysis, the edge contour of the first contact wall and the design of the arc-shaped protrusion can increase the contact area with the upper zygopophysis, and stability is improved; meanwhile, the gap height between the upper zygopophysis and the lower zygopophysis can be kept due to the existence of the lumbar zygopophysis joint gasket, inflammation and nerve compression caused by abnormal contact or displacement between the zygopophysis are avoided, therefore, clinical symptoms of the patient are relieved, and the life quality of the patient is improved.

The present invention relates to compositions comprising a mixture comprising or, alternatively, consisting of a turmeric extract and at least one compound selected from the group comprising or, alternatively, consisting of cinnamon oil and thymol for use in the treatment, preventive and / or curative, of at least one joint pathology of an inflammatory and / or degenerative nature and / or of a symptom associated therewith in human beings, or monogastric animals, by modulation of the receptors and / or enzymes of the endocannabinoid system.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

The invention discloses a triptolide-loaded engineered M2 macrophage exosome drug delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. A carrier of the delivery system is an M2 type macrophage source exosome combined and modified by phospholipid polyethylene glycol glucose; a loaded drug is triptolide, the triptolide is subjected to nano-micelle phospholipid polyethylene glycol glucose surface modification to form hypoxia response nanoparticles, M2Exo can target an inflammatory environment induced by macrophages, the specific anti-inflammatory biological function of M2Exo can be played, and the hypoxia response nanoparticles can be used for preparing the anti-inflammatory drug. Under the hypoxia condition, the compound is specifically taken by M1 macrophages, the polarization level and inflammatory response of the compound are inhibited, and the drug delivery efficiency is remarkably improved. Animal experiment model verification shows that the system can regulate and control rheumatoid arthritis synovial inflammation by regulating the polarization level of macrophages and improve the condition of arthropathy. According to the scheme, a new technical scheme is provided for precise treatment of inflammatory lesions such as rheumatoid arthritis caused by macrophages.