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Traditional Chinese medicine extract for treating rheumatoid arthritis and application of traditional Chinese medicine extract

A technology of arthritis and extracts, which is applied in the field of Chinese medicine extracts, can solve the problems that the time should not be too long, and the condition cannot be improved.

Inactive Publication Date: 2014-09-10
崔新明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Steroid hormones. Hormones are very good analgesic and anti-inflammatory drugs, but long-term use alone cannot improve the condition, but bring many side effects. Steroids can be used as a transitional second-line slow-acting drug before it takes effect, but the dosage should be limited. small, not too long
At present, there is no literature report that cucumber vine extract has biological activity in the treatment of rheumatoid arthritis

Method used

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  • Traditional Chinese medicine extract for treating rheumatoid arthritis and application of traditional Chinese medicine extract
  • Traditional Chinese medicine extract for treating rheumatoid arthritis and application of traditional Chinese medicine extract

Examples

Experimental program
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Effect test

Embodiment 1

[0012] Example 1 Preparation of cucumber vine extract

[0013] Weigh 3 kg of cucumber vines, soak them in 35 L of water for 2 hours, then decoct them for 2 hours, a total of 3 times, combine the decoctions and concentrate to a thick paste with a relative density of about 1.35 at 75 ° C, freeze-dry, crush, and pass through a 100-mesh sieve to obtain Cucumber Vine Extract.

Embodiment 2

[0014] Example 2 Preparation of cucumber vine extract

[0015] Weigh 5 kg of cucumber vines, soak them in 50 L of water for 2 hours, then decoct them for 2 hours, a total of 3 times, combine the decoctions and concentrate to a thick paste with a relative density of about 1.35 at 75 ° C, freeze-dry, crush, and pass through a 100-mesh sieve to obtain Cucumber Vine Extract.

Embodiment 3

[0016] Example 3 Study on the curative effect of cucumber vine extract on rats with adjuvant arthritis

[0017] Clean-grade healthy male Wistar rats, weighing (200±20) g, were randomly divided into 3 groups: blank control group, model control group, and drug treatment group (cucumber vine extract 120 mg / kg). The rats in the blank control group were injected with normal saline intradermally on the right hind toe; in the rest of the groups, BCG was mixed with incomplete adjuvant (BCG 10 mg / m1), emulsified into a suspension emulsion, and injected intradermally on the left hind paw of the rats. Inject 0.1ml and 0.05ml on the back to cause inflammation. After 14 days of modeling, the model replication effect was evaluated with reference to the arthritis index scoring standard (Yu Chuanbin, Immune Inflammation Model, Pharmacological Experimental Methodology, 2nd Edition [M]. Beijing: People's Medical Publishing House, 1991: 723.) For evaluation, rats with a score of 6 or more were ...

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Abstract

The invention relates to a traditional Chinese medicine extract for treating rheumatoid arthritis and application of the traditional Chinese medicine extract. The traditional Chinese medicine extract is a cucumber stem water extract. The extract is prepared by the following methods: soaking a cucumber stem by using water and then decocting and extracting; concentrating after merging an extracting solution, freezing and drying, and crushing, so as to obtain the cucumber stem water extract. By adopting the traditional Chinese medicine extract disclosed by the invention, infiltration of synovial inflammatory cells can be reduced, and the joint swelling rate, angiogenesis and cartilage destruction degree are reduced, so as to improve arthropathy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extracts, and in particular relates to a traditional Chinese medicine extract for treating rheumatoid arthritis, a pharmaceutical composition containing the extract and applications thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, progressive, symmetrical and systemic autoimmune disease with unknown etiology. It is mainly characterized by synovitis of the joints, and persistent attacks can lead to destruction of articular cartilage and bone, joint dysfunction, and even disability. From the perspective of pathological changes, RA is a generalized disease that mainly involves the synovial membrane of the joint (it can later spread to the articular cartilage, bone tissue, joint ligament and tendon), and secondarily involves the serosa, heart, lung and eye and other connective tissues. Inflammatory diseases, along with synovial cell proliferation, ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61P19/02A61P29/00
Inventor 高举梅
Owner 崔新明
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