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Cortisone acetate medicine composition and medical application thereof

A technology of cortisone acetate and a composition, applied in the field of biomedicine, can solve the problems such as no reports related to anti-inflammatory and analgesic of cortisone acetate, and achieve the effect of outstanding substantive characteristics and improved anti-inflammatory and analgesic effects.

Inactive Publication Date: 2016-09-21
蒋灵锟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between cortisone acetate and its pharmaceutical composition and anti-inflammatory and analgesic effects

Method used

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  • Cortisone acetate medicine composition and medical application thereof
  • Cortisone acetate medicine composition and medical application thereof
  • Cortisone acetate medicine composition and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Pulverize Dinggong vine (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 macroporous resin to remove impurities from the ethyl acetate extract, first elute with 20% ethanol for 12 column volumes, then use 80% ethanol for 15 column volumes, collect 80% eluate, and concentrate under reduced pressure to obtain 80% ethanol elution concentrate; (c) the 80% ethanol elution concentrate in step (b) is separated with normal phase silica gel, and the volume ratio is 80:1 (10 column volumes), 40:1 (8 column volumes) successively column volume), 20:1 ...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] Kunming mice, half male and half female (individual males used in experiments), body weight (20±2) g; Wistar rats, male, body weight (200±20) g, were provided by the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine.

[0026] 1.2 Reagents and samples

[0027]Cortisone acetate was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Aspirin enteric-coated tablets (produced by Henan Xinhui Pharmaceutical Co., Ltd.); chemical reagents such as xylene and glacial acetic acid were of analytical grade, and the egg white solution was freshly prepared.

[0028] 1.3 Instruments

[0029] Self-made toe swelling tester

[0030] 1.4 Mouse ear swelling experiment caused by xylene

[0031] Take 50 mice, male, and randomly d...

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PUM

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Abstract

The invention discloses a cortisone acetate medicine composition and medical application thereof. The cortisone acetate medicine composition contains cortisone acetate and a natural product compound (I) of a novel structure, and when cortisone acetate and the compound (I) work independently, the anti-inflammatory and analgesic functions are achieved; when cortisone acetate and the compound (I) work together, the anti-inflammatory and analgesic functions are further improved, and cortisone acetate and the compound (I) can be developed into anti-inflammatory and analgesic medicine. Compared with the prior art, the medicine composition has outstanding substantial characteristics and makes remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of cortisone acetate, in particular to a pharmaceutical composition of cortisone acetate and its medical application. Background technique [0002] Cortisone acetate is an adrenocortical hormone commonly used in clinical endocrine system. [0003] So far, there has been no report on the correlation between cortisone acetate and its pharmaceutical composition and anti-inflammatory and analgesic effects. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of cortisone acetate, containing cortisone acetate and a novel natural product in the pharmaceutical composition, and cortisone acetate and the natural product can synergistically resist inflammation and analgesia . [0005] Above-mentioned purpose of the present invention is achieved by following technical scheme: [0006] A compound (I) having the follow...

Claims

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Application Information

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IPC IPC(8): C07D303/48C07D301/32A61K31/573A61K31/336A61P29/00
CPCC07D303/48A61K31/336A61K31/573A61K36/39C07D301/32
Inventor 蒋灵锟
Owner 蒋灵锟
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