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53 results about "Cortisone acetate" patented technology
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Cortisone acetate (brand names Adreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others) is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed in many countries throughout the world, including in the United States, the United Kingdom, and various other European countries. It is the C21 acetate ester of cortisone, and acts as a prodrug of cortisone in the body.
Method for producing prednisolone acetate
InactiveCN101210259AStrong response specificityEasy to operateMicroorganism based processesFermentationMicrobial transformationArthrobacter simplex
The invention belongs to the field of microbial pharmaceutics and pharmaceutical engineering, specifically relates to a production method of prednisone acetate by microbial transformation with Arthrobacter simplex as bacteria strain and hydrocortisone acetate as substrate. The method uses Arthrobacter simplex as bacteria strain and comprises the following steps of: performing primary seed culture, performing second fermentation culture, adding hydrocortisone acetate into the fermentation liquid of Arthrobacter simplex to transform hydrocortisone acetate into prednisone acetate, filtering, and collecting cake to obtain prednisone acetate. The bacteria can be prepared into double liquid phase, broken cells or protoplast, each of which has high transformation ratio. The inventive production method replaces cortisone acetate with hydrocortisone acetate as raw material, and has the advantages of high yield, simple process, good economical and practical performance, and less use of harmful reagents; and is important for steroids production with biotransformation method.
Owner:TIANJIN UNIV OF SCI & TECH
Preparation method of important intermediate of cortisone acetate
Owner:JIANGSU YUANDA XIANLE PHARMA
Method for preparing prednisolone through bio-fermentation in one step
The invention relates to a method for directly generating prednisolone through bio-fermentation in one step by using cortisone acetate as a raw material and Arthrobacter Simple ATCC 21032.
Owner:TIANJIN JINYAO GRP
Method for preparing prednisone acetate
InactiveCN108588163AImprove conversion rateImprove refining efficiencyMicroorganism based processesFermentationArthrobacter simplexSolvent
Owner:ZHEJIANG XIANJU PHARMA
Preparation method of cortisone acetate
The invention relates to a preparation method of cortisone acetate. Anecortave acetate is used as a raw material and sequentially takes addition, oxidization and reduction reaction to obtain the anecortave acetate. The method comprises the following reaction steps of A, addition reaction: under the nitrogen production, adding the anecortave acetate into an organic solvent; adding a halogenating reagent and an acid catalyst to obtain an intermediate II; B, oxidization reaction: under the nitrogen gas protection, adding the compound II into the organic solvent; adding an oxidizing agent to obtain an intermediate III; C, reduction reaction: under the nitrogen gas production, adding the compound III into the organic solvent; adding an acid catalyst and a reducing agent to obtain a target product of the cortisone acetate IV. The method has the advantages that the raw materials can be easily obtained; the reaction steps are few; the quality and the yield achieve the obvious competitiveness; in addition, the pollution on the environment is reduced.
Owner:HENAN LIHUA PHARMA
Preparation method of cortisone acetate
The invention discloses a preparation method of cortisone acetate. According to the method, hydrocortisone is taken as an initiator, and preparation is performed through steps including acetylation, oxidization and the like. Sodium hypochlorite which is low in cost and environment-friendly is used for replacing chromic anhydride which is high in cost and larger in toxicity and serves as an oxidizing agent in an oxidation reaction, and a catalyst which cannot be recovered and recycled is not required in an oxidation reaction process. The preparation method of the cortisone acetate has the advantages that the production cost is reduced, the production operation is simplified, environmentally hazardous chromium ion wastewater is not discharged, and the method is suitable for industrial production.
Owner:HUAZHONG PHARMA
Preparation method of cortisone acetate
The invention discloses a preparation method of cortisone acetate, and belongs to the field of pharmaceutical chemistry. According to the method, 11 alpha-hydroxy- 16 alpha, 17 alpha-epoxy progesterone is used as a raw material to prepare the cortisone acetate through bromine reaction, debromination reaction, bromination reaction, replacement reaction and oxidation reaction. The method can effectively avoid the occurrence of side reactions, and improves the quality of the product; at the same time, iodine is replaced by low-cost bromine for halogenating reaction, the production cost is greatly reduced, the method is high in efficiency and low in energy consumption, and the product quality and yield are good.
Owner:HENAN LIHUA PHARMA
Process for preparing hydrocortisone
InactiveCN102827231AChange crystal formComplete crystal formSteroidsBulk chemical productionAlkaneHydrocortisone
The invention discloses a process for preparing hydrocortisone, and belongs to the field of chemical pharmacy. The process comprises the following steps of: preparing a reducing matter by using cortisone acetate as a raw material; removing a protecting group to acquire the hydrocortisone; in the step of removing the protecting group, adding the reducing matter into uniformly-mixed solution of hydrochloric acid solution and chloralkane; stirring and dissolving clearly; and dipping sodium nitrite solution under a certain temperature to separate out hydrocortisone. With the adoption of the process, the side reaction caused by a large quantity of auxiliary materials during the removal of the protecting group is avoided, so that the product is pure; the production cost is reduced; the hydrocortisone is easily crystallized in heterogeneous solution of the chloralkane and the water; and the crystal form is better than that in the traditional process.
Owner:HENAN LIHUA PHARMA
Method for separating and detecting six cortical hormones in skin-care cosmetic
The invention provides a method for separating and detecting six cortical hormones in a skin-care cosmetic. The six cortical hormones, i.e. fluticasone propionate, triamcinolone acetonide, cortisone acetate, dexamethasone, hydrocortisone and prednisone, in the cosmetic are separated and detected by a reverse micro emulsion electrokinetic chromatography (MEEKC) with ionic liquid and beta-cyclodextrin as additives. Compared with a conventional MEEKC separation and detection method, the method has higher separation degree. An experiment result shows that the method is simple in sample treatment, low in using amount, economic, high in speed, and high in separation degree and sensitivity. Capillary electrophoretic detection on the cortical hormones in the cosmetic is realized by the method.
Owner:JIANGNAN UNIV
Cortisone acetate intermediate, preparation method and use thereof in preparation of cortisone acetate
InactiveCN104098642ARaw materials are cheap and easy to getSimple and stable processSteroidsSynthesis methodsCortisone acetate
The invention discloses a cortisone acetate synthesis method and an intermediate compound IV used in cortisone acetate synthesis. The cortisone acetate synthesis method has the advantages of cheap and easily obtained raw materials, short route, convenient operation and high yield. The reaction route of the cortisone acetate synthesis method is shown in the specification.
Owner:沈敬山
Preparation method of hydrocortisone acetate
InactiveCN102827230AAvoid it happening againRaw materials are easy to getSteroidsEthylic acidAcetylation
The invention discloses a preparation method of hydrocortisone acetate, belonging to the field of chemical pharmacy. The preparation method comprises the following steps: by using an intermediate Pu's oxide in the traditional cortisone acetate synthesis technique as a raw material, sequentially carrying out ketalation reaction, reduction reaction, hydrolysis reaction, iodine reaction and acetylation reaction under certain conditions to obtain the product hydrocortisone acetate. The preparation method of hydrocortisone acetate has the advantages of accessible raw materials and common auxiliary materials, and does not need some toxic, virulent and cancerigenic reagents in the original technique. The invention is environment-friendly and effective; the product has both high quality and yield; and the HPLC (high performance liquid chromatography) content is up to higher than 98.5%, and the yield is up to higher than 80%.
Owner:HENAN LIHUA PHARMA
Method for preparing cortisone acetate in one pot
ActiveCN109942660AEmission reductionProcess method energy saving and consumption reductionSteroidsSulfite saltOrganic layer
Provided is a method for preparing cortisone acetate in one pot. According to the method, Anecortave acetate is adopted as a raw material, and after the raw material is added into an organic solvent,a pot is adopted for preparation. The method comprises the following steps of A, adding a compound I into a mixed organic solvent and adding a halogenating reagent and an acid catalyst, wherein the reaction temperature is controlled in a range from -10 DEG C to 30 DEG C; after the reaction is finished, adding a quencher to quench the reaction, wherein the quencher comprises a sodium sulfite solution or a sodium bisulfite solution; B, adding an oxidant into a system finally obtained in step A, wherein the oxidant is a Jones reagent or pyridine chlorochromate or a Dess-Martin oxidant used for anoxidization reaction, and the reaction temperature is controlled in a range from -10 DEG C to 30 DEG C; after the reaction is finished, adding the quencher to quench the reaction; C, adding an organic acid catalyst and a reducing agent into an organic layer finally obtained in step B to obtain a target product cortisone acetate IV. The preparation method greatly reduces the discharge amount of waste liquid.
Owner:HENAN LIHUA PHARMA
Preparing method of cortisone acetate
The invention provides a preparing method of cortisone acetate. The method comprises the three following steps of iodine solution preparation, the iodo reaction and the replacement reaction. In the step one, an idodine solution and bromine are mixed to prepare bromine and iodine liquid. In the step two of the iodo reaction, a reactant 17 alpha-hydroxyl-pregnene-4-alkene-3,11,20-triketone (I) and the bromine and iodine liquid are subjected to the iodo reaction to obtain an intermediate product iodine substitute (II). In the step three of the replacement reaction, the iodine substitute (II) and acetate are subjected to the replacement reaction to obtain a final product cortisone acetate (III). According to the preparing method, the bromine and iodine mixture iodo reaction replaces the traditional iodo reaction, the amount of adopted iodine is reduced greatly, cost is low, environmental pollution is reduced, and applicability is high.
Owner:河北远大九孚生物科技有限公司
Preparation method of cortisone acetate
ActiveCN103232514AReduce manufacturing costImprove the production operating environmentSteroidsEpoxyKetone
The invention discloses a preparation method of cortisone acetate, which comprises the following steps: preparing the raw material 11-hydroxy-16,17-epoxy-4-ene-3,20-dione into 17-alpha-hydroxy-4-pregnene-3,11,20-trione; and carrying out substitution and replacement reaction on the 17-alpha-hydroxy-4-pregnene-3,11,20-trione with raw materials bromine, potassium acetate and the like to obtain the cortisone acetate. The method specifically comprises the following steps:(a) in an inert gas protective atmosphere, reacting 17-alpha-hydroxy-4-pregnene-3,11,20-trione with pyrrolidine by using alcohol as a solvent to obtain an intermediate compound A; and (b) in an inert gas protective atmosphere and in the presence of catalysts methylsulfonic acid and triethyl orthoformate, carrying out substitution reaction on the intermediate compound A and bromine by using alcohol as a solvent, and carrying out replacement reaction on the product and postassium acetate to obtain the cortisone acetate. The new process disclosed by the invention can greatly lower the production cost of cortisone acetate.
Owner:河北远大九孚生物科技有限公司
Method for producing 6 alpha-methylprednisolone and its derivatives
InactiveCN1978457AStrong response specificityHigh yieldSteroids preparationKetone6Alpha-Methylprednisolone
This invention discloses a 6alpha-methylprednisolone and production method of its derivate. This invention uses cortisone acetate and its derivate as raw material to produce 6alpha-methylprednisolone and its derivate. Its production method includes steps such as: lead-in methenyl at sixth position, methenyl is transformed to alpha-methyl, 1,2 position is dehydrogenated to 6alpha-methyl prednisoni acetasby by method of arthrobacterium biotransformation, then selectively hydrogenise 11-ketone to 11 beta-hydroxy group. Using this invention can obtain higher 6alpha-methylprednisolone and yield and quality of its derivate. This invention has characteristics such as: position specificity is high, yield is high. It has important significance for preparing steroid medicine.
Owner:ZHEJIANG UNIV
Method for treating prednisone acetate mother liquor
The invention relates to the technical field of chemical pharmacy, in particular to a method for treating prednisone acetate mother liquor. The method comprises the following steps: (1) adding a solvent and alkali liquor into the prednisone acetate mother liquor to carry out hydrolysis reaction; (2) after the hydrolysis reaction is finished, adjusting the reaction liquid to be neutral, concentrating under reduced pressure until a large amount of crystals are separated out, and performing suction filtration to obtain a hydrolysate crude product; (3) adding the hydrolysate crude product into a solvent, and refining to obtain a hydrolyzed refined product; (4) adding the hydrolyzed refined substance and a catalyst into a solvent, and reacting with acetic anhydride to obtain a mixture of prednisone acetate and cortisone acetate; and (5) fermenting and dehydrogenating the mixture to obtain the prednisone acetate. According to the treatment method, the prednisone acetate in the prednisone acetate mother liquor can be recycled, particularly, the prednisone acetate in the mother liquor can be recycled, the treatment cost is saved, and the yield of the prednisone acetate is increased; The method can well remove the dehydrogenation RSA and RSA impurities, and is stable in processand simple to operate.
Owner:HENAN LIHUA PHARMA
Method for preparing hydrocortisone
The invention relates to a method for preparing hydrocortisone. The method includes: subjecting a cortisone acetate raw material to sites No. 3,20-keto protective reaction, site No.11-keto reduction reaction, site No.21-hydroxy esterification reaction, sites No. 3,20-ketone deprotection reaction, and site No. 21-acetate hydrolysis to obtain hydrocortisone. The method provides a new synthetic route containing esterification and deprotection in order, greatly improves the reaction selectivity, easily separates deprotection reaction products and avoids the posttreatment of tedious several times of extraction of a large amount of solvents in the traditional deprotection reaction process, and also avoids the side reaction caused by quenching reaction in the posttreatment of the traditional process; and the ester hydrolysis reaction is carried out under protection of inert gases in a mixed solvent, so as to avoid by-products produced in the hydrolysis reaction. The process route of the invention is novel, simple for operation, low in production cost, and applicable to industrial scale production.
Owner:HUAZHONG PHARMA
Process method for producing intermediate 3,20-diethylene glycol of betamethasone serial products
InactiveCN101560238AHigh yieldQuality improvementOrganic-compounds/hydrides/coordination-complexes catalystsSteroidsBoron trifluorideDiethylene glycol
The invention discloses a process method for producing an intermediate 3,20-diethylene glycol of betamethasone serial products, which belongs to the field of chemical medicaments. The method comprises the following steps: using a cortisone acetate intermediate prowazekii oxide (1) and glycol as raw materials, boron trifluoride and triethyl orthoformate as catalysts, and chloralkane as a menstruum to perform reaction; and concentrating, crystallizing, filtering, washing and drying the reactants to obtain a reaction product. The method can increase the batch charging concentration, shorten the reaction time, and greatly improve the yield and the quality of a condensation compound. Besides, the method reduces the equipment loss, avoids the use of benzene solvents which are more harmful, and greatly reduces the harm to health and the pollution to the environment.
Owner:HENAN LIHUA PHARMA
Method for preparing prednisolone through bio-fermentation in one step
The invention relates to a method for directly generating prednisolone through bio-fermentation in one step by using hydrocortisone acetate as a raw material and Arthrobacter Simple ATCC 21032.
Owner:TIANJIN JINYAO GRP
Preparation method of important intermediate of cortisone acetate
Owner:JIANGSU YUANDA XIANLE PHARMA
Preparation method of hydrocortisone
The invention relates to a preparation method of hydrocortisone. The preparation method comprises the following steps: by taking cortisone acetate as a raw material and orderly carrying out a 3-site / 20-site keto protection reaction, a 11-site keto reduction reaction and a 3-site / 20-site keto deprotection reaction to obtain the hydrocortisone. The preparation method of the hydrocortisone has the advantages that the use of a toxic carcinogenic reagent in a traditional process is avoided, the selectivity of the reactions are greatly improved, meanwhile, the after-treatment mode of multiple extraction by use of a large amount of solvent is avoided, and the production cost is low; as a result, the preparation method is suitable for industrial large-scale production.
Owner:HUAZHONG PHARMA
Preparation method for compound cortisone acetate
The invention discloses a preparation method of a compound cortisone acetate. The method takes a compound 4-pregnen-11(alpha),17(alpha)-alcohol-3,20-diketone (I) as a raw material and a mixed solution of chromic anhydride, sulfuric acid and water as an oxidation reagent, and comprises the following steps of: oxidizing the eleventh site to obtain a compound 4-pregnen-17(alpha)-alcohol-3,11,20-triketone (II); then iodizing the twenty-first site to obtain a compound 4-pregnen-21-iodine-17(alpha)-alcohol-3,11,20-triketone (III); and finally performing a replacement reaction to enable the compound 4-pregnen-21-iodine-17(alpha)-alcohol-3,11,20-triketone (III) to react with potassium acetate in a replacement reaction solvent to obtain a compound 4-pregnen-21-iodine-17(alpha),21-diol-3,11,20-triketone-21-acetate (IV), namely cortisone acetate. Through the invention, the dangerous operation of bromination and hydrogenation reaction can be avoided, the product yield can be improved, the process cost can be lowered, and the production is more economical, safer and more environment-friendly, thus the method is more suitable for industrial production.
Owner:ZHEJIANG XIANJU PHARMA
Refining method of hydrocortisone acetate
Owner:HUNAN NORCHEM PHARMACEUTICAL CO LTD
Recycling method of cortisone acetate biological catalysis cyclodextrin medium
ActiveCN103695521AAchieve recyclingRealize biocatalytic clean productionMicroorganism based processesChemical recyclingOrganic solventCyclodextrin
The invention relates to a recycling method of a cortisone acetate biological catalysis cyclodextrin medium, and belongs to the technical field of biotransformation. The recycling method comprises the following steps of: processing a cyclodextrin-containing transfer solution by filtering and extracting with an organic solvent; removing the residual organic solvent from a cyclodextrin-containing extraction phase; adding to perform biological catalysis of a water repellent compound again, thus realizing the recycle of high-price cyclodextrin as well as environmentally-friendly and clean production of biological catalysis. The recycling method saves the production cost, and has a wide application prospect.
Owner:TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Medicinal composition for treating lung diseases, as well as preparation method and use of medicinal composition
ActiveCN105920020AIncrease profitPromote absorptionAntibacterial agentsDispersion deliveryDiseaseHigh energy
The invention discloses a medicinal composition for treating lung diseases, as well as a preparation method and use of the medicinal composition. The medicinal composition is prepared according to the proportion of carbamide: cortisone acetate: dexamethasone: N-acetyl-cysteine: heparin sodium: sorbitan tri-oleate: 1,1,1,2-tetrafluoroethane: methylparaben of 1:(1-4):(1-3):2:2:2:5:1, and is loaded into an aerosol can with a quantitative aerosol valve to prepare aerosol; active ingredients of the medicinal composition are subjected to freeze drying at first, then are micronized by adopting a high-energy ball mill or jet mill technology, and are loaded into the aerosol can of which the medicament release range of the quantitative aerosol valve is 30 to 250 microliters. The medicinal composition is directly administrated through the lung, so that the utilization rate of the medicinal composition is increased, anti-inflammation and antiviral effects are achieved, and meanwhile, the oxygen absorption of a patient is increased.
Owner:潘海英
Medicament for treating herpes and neurodermatitis
InactiveCN101618042AGood treatment effectGood for itchingOrganic active ingredientsAntimycoticsTreatment effectEye drop
The invention relates to a medicament for treating herpes and neurodermatitis, which is prepared from the following components in percentage by weight: 0.2 to 0.6 g of chlorpheniramine maleate, 0.8 to 1.2 g of fosfomycin sodium, 0.01 to 0.02 g of cortisone acetate eye drops, 8 to 12 g of compositus mentholi cream and 8 to 12 g of triamcinolone acetonide acetate and miconazole nitrate and neomycin sulfate cream. The medicament for treating the herpes and the neurodermatitis has the advantages of good treatment effects on herpes, neurodermatitis, beriberi, psoriasis and cutaneous pruritus, quick response and short healing time.
Owner:江燕
Compound medicine for treating migraine headache
InactiveCN1861083AEasy to useFormulation ScienceNervous disorderHeterocyclic compound active ingredientsAspirinIndometacin
A compound medicine for treating hemicrania is proportionally prepared from aspirin, caffeine, indometacin and cortal.
Owner:金桂兰 +2
Preparation method of high-quality prednisone acetate and intermediate thereof
InactiveCN110862431AHigh feeding concentrationGood conversion effectMicroorganism based processesSteroidsHydrocortisoneDehydrogenation
The invention discloses a preparation method of high-quality prednisone acetate and an intermediate thereof. The method includes the steps of: taking epihydrocortisone as the raw material, firstly conducting microbial dehydrogenation to obtain 11alpha, 17alpha, 21-trihydroxy-pregn-1, 4-diene-3, 20-dione intermediate, then carrying out esterification reaction to obtain 11alpha, 17alpha, 21-trihydroxy-pregn-1, 4-diene-3, 20-dione-21-acetate, and finally carrying out oxidation reaction to obtain prednisone acetate. The method provided by the invention solves the technical difficulty of non-idealintroduction of C1, 2 double bond in the traditional fermentation production process of prednisone acetate. The cortisone acetate prepared by the method provided by the invention has high quality andextremely low impurity content, greatly improves the multidirectional application of prednisone acetate, and meanwhile, the process route has the characteristics of low cost and simple operation.
Owner:HUAZHONG PHARMA
The preparation method of cortisone acetate
Owner:HUNAN NORCHEM PHARMACEUTICAL CO LTD
Compound medicine for treating migraine headache
InactiveCN1861083BEasy to useFormulation ScienceNervous disorderHeterocyclic compound active ingredientsAspirinIndometacin
A compound medicine for treating hemicrania is proportionally prepared from aspirin, caffeine, indometacin and cortal.
Owner:金桂兰 +2
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