Preparation method of hydrocortisone acetate

Abstract

The invention discloses a preparation method of hydrocortisone acetate, belonging to the field of chemical pharmacy. The preparation method comprises the following steps: by using an intermediate Pu's oxide in the traditional cortisone acetate synthesis technique as a raw material, sequentially carrying out ketalation reaction, reduction reaction, hydrolysis reaction, iodine reaction and acetylation reaction under certain conditions to obtain the product hydrocortisone acetate. The preparation method of hydrocortisone acetate has the advantages of accessible raw materials and common auxiliary materials, and does not need some toxic, virulent and cancerigenic reagents in the original technique. The invention is environment-friendly and effective; the product has both high quality and yield; and the HPLC (high performance liquid chromatography) content is up to higher than 98.5%, and the yield is up to higher than 80%.

Description

technical field [0001] The invention relates to a preparation method of hydrocortisone acetate, in particular to an environmentally friendly preparation method of medicinal hydrocortisone acetate, which belongs to the field of chemical pharmacy. Background technique [0002] Hydrocortisone acetate is mainly used to treat rheumatoid arthritis, rheumatic fever, gout, and bronchial asthma. Injections are used for tuberculous or suppurative meningitis, tuberculous pleurisy, empyema, arthritis, tenosynovitis, tendon strain, sprains, prurigo nodosa, lichen planus, etc. Eye drops are used for various ophthalmic conditions. Creams are used for allergic or seborrheic dermatitis, pruritus, etc. Is an important corticosteroid drugs. [0003] Hydrocortisone acetate is mainly prepared by the reaction of hydrocortisone and acetic anhydride. Traditionally, pyridine is used as a solvent and catalyst for reaction to prepare hydrocortisone acetate. Its disadvantage is that pyridine is hi...

AI Technical Summary

Problems solved by technology

The present invention provides a method for preparing hydrocortisone acetate, which can effectively overcome the shortcomings and deficiencies of the above-mentioned prior art, such as large pollution and unsafe conditions.

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