The invention discloses a preparation method of
puerarin and
hyaluronic acid nano-micelles. The method comprises the following steps that 1, a solution I of a
hyaluronic acid derivative is obtained through
dissolution; 2, ADH is dissolved to prepare a solution II; 3, the solution I is added into the solution II drop by drop, the
system pH is adjusted, and after reaction, a
hyaluronic acid-ADH intermediate is obtained through
centrifugal separation and
drying; 4, the hyaluronic acid-ADH intermediate and a
puerarin derivative are fully dissolved, and then a catalyst is added into the mixture toprepare the
puerarin and hyaluronic acid nano-micelles; 5, the puerarin and hyaluronic acid nano-micelles are added into an organic dispersion phase, the puerarin and hyaluronic acid nano-micelles andpuerarin are mixed,
dialysis treatment is conducted, and finally, a
solid product of the puerarin and hyaluronic acid nano-micelles is obtained. The method has the advantages that operation is convenient, the preparation technology is simple and stable, and the production cost is low; by means of the study, the
curative effect of the puerarin is improved, adverse reaction of the puerarin is reduced, and a novel production technology is provided for developing a novel puerarin replacement
medicine.