Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cortisone acetate intermediate, preparation method and use thereof in preparation of cortisone acetate

A technology of acetate and strong acid, applied in the field of medicine and chemical industry, can solve the problems of low yield, long route, high cost, etc., and achieve the effect of high yield, strong operability, simple and stable process

Inactive Publication Date: 2014-10-15
沈敬山
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many synthetic methods of existing cortisone acetate, but there are problems such as long route, low yield, high cost and serious pollution.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cortisone acetate intermediate, preparation method and use thereof in preparation of cortisone acetate
  • Cortisone acetate intermediate, preparation method and use thereof in preparation of cortisone acetate
  • Cortisone acetate intermediate, preparation method and use thereof in preparation of cortisone acetate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of 4-ene-pregna-3,11,17-trione (compound of formula II)

[0040] Add 4-ene-pregna-11α-hydroxyl-3,17-dione (compound of formula I) (100 g) (obtained through commercial purchase) and 2-butanone (800 ml) in a 2L reaction flask, and cool to 0 At about -10°C, add Jones reagent (150ml) dropwise (calculated as chromium trioxide, 1.1 equivalents), and the addition is completed in about 0.5 hours. After the raw materials are completely consumed, stop the reaction, stir at room temperature, add isopropanol (3ml) to destroy the oxidant, stir for 0.5h, add water (1L) to stir, let stand to separate the layers, separate the organic phase, and use ethyl acetate (200ml ) extraction, combined the organic phase, and added the organic phase to the rotary evaporator for concentration. When about half of the solvent remained, add water (about 500ml) to continue the concentration until the solvent was completely evaporated, and the product was precipitated in water as a white pow...

Embodiment 2

[0042] Preparation of 4-ene-pregna-3,11,17-trione (compound of formula II)

[0043] Add 4-ene-pregna-11α-hydroxy-3,17-dione (compound of formula Ⅰ) (50g), acetone (100ml) into a 2L reaction flask, cool down to about 0-10°C in an ice bath, and add Jones reagent dropwise (75ml) (calculated as chromium trioxide, 1.1 equivalent), about 0.5 hours to complete the addition, after the addition, keep warm overnight. When there is almost no remaining raw material, stop the reaction, stir at room temperature, add isopropanol (1ml) to destroy the oxidant, and concentrate directly after stirring for 0.5h. When about half of the solvent remains, add water (about 500ml) and continue to concentrate until the solvent is completely evaporated. The product was precipitated in water as a light brown powdery solid. Dry at 50°C to obtain 48.1 g of the product with a purity of about 98% and a yield of 97%.

Embodiment 3

[0045] Preparation of 4-ene-pregna-3,11,17-trione (compound of formula II)

[0046] Add 4-ene-pregna-11α-hydroxyl-3,17-dione (compound of formula I) (200g), dichloromethane (1000ml), water (400ml) into the 3L reaction flask, cool to 0-10 At about ℃, Jones reagent (290ml) (calculated as chromium trioxide, 1.1 equivalents) was added dropwise. The addition was completed in about 50 minutes, and after the addition was completed, the reaction was incubated overnight. After the reaction of the raw materials is complete, add isopropanol (6ml) to destroy the oxidant, stir for 1 hour and then separate the layers, separate the organic phase, extract the aqueous phase with dichloromethane (100ml x 1), combine the organic phases, and wash with water (200ml x 1). Wash to remove inorganic matter, add water to the organic phase at a volume ratio of 1:1, and then concentrate under reduced pressure. The product precipitates in the water phase as a white solid. After filtration, it is dried at...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a cortisone acetate synthesis method and an intermediate compound IV used in cortisone acetate synthesis. The cortisone acetate synthesis method has the advantages of cheap and easily obtained raw materials, short route, convenient operation and high yield. The reaction route of the cortisone acetate synthesis method is shown in the specification.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to an intermediate of cortisone acetate, a preparation method thereof and a new method for preparing cortisone acetate by using the intermediate. The method for preparing cortisone acetate has the advantages of cheap and easy-to-obtain raw materials, short route, convenient operation and high yield. Background technique [0002] Cortisone acetate (compound of formula VI), chemical name: 17a,21-dihydroxypregn-4-ene-3,11,20-trione 21-acetate. [0003] [0004] Cortisone acetate has anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects, and reduces the manifestations of inflammation by reducing and preventing tissue responses to inflammation. It can inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07J41/00C07J5/00
Inventor 朱富强杨小军陈伟铭
Owner 沈敬山
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com