Method of preparing 4-hydroxy pyrrolidone-2-acetamine

A technology for hydroxypyrrolidone and pyrrolidone, which is applied in the field of preparing 4-hydroxypyrrolidone-2-acetamide, can solve the problems that the purity cannot be fully used for medicine, cannot meet the requirements of industrial scale production, and the product composition is complicated, and the raw materials are cheap and the cost is achieved. Low cost, easy availability of raw materials
CN1513836AInactive Publication Date: 2004-07-21SUZHOU HOPE TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU HOPE TECH
Publication Date
2004-07-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for preparing 4-hydroxypyrrolidone-2-acetylamine used as brain function improver includes reacting between 4-haloacetoacetic acid derivative and the azide of alkali metal or alkali-earth metal to obtain 4-azoacetoacetic acid derivative, hydrogenating, cyclizing, and ammoniating. Its advantages are high quality and output rate of product, and low cost.
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Description

technical field

[0001] The invention relates to a method for preparing 4-hydroxypyrrolidone-2-acetamide. Background technique

[0002] 4-Hydroxypyrrolidone-2-acetamide, commonly known as oxiracetam, is used in medicine as a brain function improver.

[0003] U.S. Patents US4824861 and US4868313 describe the preparation method of oxiracetam, which are based on 3-hydroxy-4-halogenated butyric acid derivatives, with chemical reactions such as hydroxyl protection, cyclization, deprotection, and ammoniation process to prepare the desired product.

[0004] The above-mentioned preparation method is not suitable for industrial scale production, because it has many disadvantages, such as the use of expensive dihydropyran as a hydroxyl protecting group, and finally the dihydropyran after removal of the protecting group is very difficult to recover. And the yield in each step of the reaction process is very low. In addition, during this reaction process, the intermediate obtained in ...

Claims

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