Preparation method of folium sennae extract for health food

Abstract

The invention belongs to the technical field of preparation of drugs, and particularly relates to a preparation method of a folium sennae extract for health food. The preparation method comprises: (1)crushing: crushing a herb folium sennae into coarse powder or fine powder according to the requirement; (2) extracting: carrying out ultrasonic extraction on the crushed herb by using water as solvent; (3) concentrating and impurity removing: carrying out concentrating and impurity removing on the filtrate by using a membrane filtration device, carrying out ultra-filtration treatment with a filtration membrane, and collecting the product concentrated liquid; and (4) drying: carrying out freeze drying on the collected product concentrated liquid, and carrying out pressure reducing freeze drying to obtain the solid powder. According to the present invention, the method has advantages of simple process, low energy consumption, short production period and easily controlled cost, and does notuse organic reagents and acid-alkali solutions so as not to cause environmental pollution; and the obtained folium sennae extract has characteristics of high effective component content and less side-effect component, and can be used for industrial production.

Description

Technical field: [0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of senna leaf extract used for health food. Background technique: [0002] Senna is a traditional Chinese medicine, which is the dried leaflet of Cassia angustifolia Vahl or Cassia acutifolia Delile, a leguminous herb. Traditional Chinese medicine believes that this product is cold in nature, sweet and bitter in taste, and belongs to the large intestine meridian. It has the effects of purging heat and stagnation, and promoting water. In recent years, it has been mainly used for intestinal cleaning before various imaging examinations of the abdomen and intestinal tract or before surgery, and for the treatment of constipation. Analysis of existing data shows that it has become the most widely used cathartic in the world, and the market development prospect is good. [0003] Studies have shown that the main components of senna are a class of unst...

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Problems solved by technology

Chinese patent 200510095338.0 discloses a method for preparing senna leaf extract by using reflux heat extraction, acid-base treatment to remove impurities and resin enrichment. Although sennoside is enriched, it does not control substances that produce side effects such as aloe-emodin

Patent 200610130604.3 discloses a method of alcohol extraction combined with resin column chromatography and acid-base treatment, which can not only enrich sennosides, but also control the content of substances such as aloe-emodin that can cause side effects, which is a step further than the former, but this The method also has many operating steps, many variable factors, difficult quality control, and the use of organic solvents and acid-base solutions may have an impact on the environment and the risk of residues in resin chromatography, and there are also active ingredients that are easy to process The risk of changes caused by heat and acid-base influences in the process will affect the safety of use

Patent CN201010293147.6 discloses a method for extracting sennosides. This method adopts the method of adjusting neutrality to place crystals, washing with absolute ethanol and vacuum drying to obtain the product. However, the active ingredients extracted from senna leaves are thermally unstable. Using this method will make Sennoside loss

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