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Preparation method of compound lamotrigine subcutaneous implantable controlled-release glue rod

A technology for compound lamotrigine and lamotrigine, which is applied in the directions of pharmaceutical formulations, active ingredients of heterocyclic compounds, and nervous system diseases, etc., can solve the loss of control of emotional stability, the reduction of drug treatment effect, and the lack of patient compliance. and other problems, to achieve the effect of effective blood drug concentration, excellent controlled release effect and simple structure

Inactive Publication Date: 2014-08-20
郑玉华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At the same time, for some patients, during the acute treatment, one-time large doses of drugs or larger doses of common preparations prepared according to conventional methods are given in daily treatment to maintain a high drug concentration in the plasma, which often has toxic and side effects that patients cannot tolerate.
At the same time, the use of such common drugs is to take drugs at intervals, for example, two to three times a day, there will be fluctuations in the drug concentration level in the patient's body, that is, the peak-valley effect in medicine, which will lead to the lack of compliance of the patient, thus making the drug Decreased effectiveness of treatment or loss of control over emotional stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A compound lamotrigine slow-release glue stick for subcutaneous implantation is made of the following raw materials: 100 grams of lamotrigine, 40 grams of alprazolam, and 0.005 grams of propionic acid; Prazolam and propionic acid controlled-release agent are uniformly mixed and made into granules and wrapped in multiple medical silicone tubes.

[0029] The preparation method of the compound lamotrigine subcutaneous implantation slow-release glue stick of the present embodiment comprises the following steps:

[0030] 1) Preparation of raw materials: Confirm the quality of the required medical silicone tubes, lamotrigine, propionic acid controlled release agent, and medical adhesives, and carry out necessary disinfection treatment;

[0031] 2) Compound drug preparation: in order to fully and evenly mix lamotrigine and propionic acid controlled-release agent, put 100 grams of lamotrigine, alprazolam gram and 0.005 gram of propionic acid into the container, and then add 60%...

Embodiment 2

[0037] A compound lamotrigine subcutaneous implant slow-release glue stick is made from the following raw materials: 1000 grams of lamotrigine, 400 grams of alprazolam, and 0.08 grams of propionic acid controlled-release agent, mixed uniformly and prepared It is granulated and wrapped in multiple medical silicone tubes.

[0038] The preparation method of the compound lamotrigine subcutaneous implant slow-release glue stick of this embodiment is the same as that of Embodiment 1, the organic solvent used is 80% ethanol, and the medical adhesive used is medical silica gel.

Embodiment 3

[0040] A compound lamotrigine slow-release glue stick for subcutaneous implantation is made of the following raw materials: 100 grams of lamotrigine, 40 grams of alprazolam, and 0.04 grams of propionic acid controlled-release agent are uniformly mixed and prepared The granular form is wrapped in multiple medical silicone tubes.

[0041] The preparation method of the compound lamotrigine subcutaneous implant slow-release glue stick of this example is the same as that of Example 1, the organic solvent used is 70% ethanol, and the medical adhesive used is acrylic orthopedic cement.

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Abstract

The invention relates to a compound lamotrigine subcutaneous implantable controlled-release glue rod, which contains lamotrigine, alprazolam and a controlled-release agent. The compound lamotrigine subcutaneous implantable controlled-release glue rod can be implanted into a loose part of the lower abdominal wall subcutaneous tissues of a patient by using small incision and trocar introduction, after the patient obtains satisfactory curative effect from acute treatment; the controlled-release glue rod is lasting in curative effect, economical and practical, and the curative effect can be controlled at about 1 year for each implantation; and the drug is guided by the controlled-release agent and releases slowly at a uniform speed through a medical silica gel film wall, so as to guarantee stable and effective blood drug level and achieve the purpose of therapy maintenance. The controlled-release glue rod is applicable to patients with all types of epilepsy (induced mental disorders), mood disorders and other indications for lamotrigine treatment.

Description

technical field [0001] The invention relates to a preparation method of a compound lamotrigine subcutaneously implanted slow-release glue stick, belonging to the technical field of antiepileptic and antipsychotic medical drugs. Background technique [0002] In the fields of neurology and psychiatry, epilepsy and mood disorders are chronic diseases with recurrent or even lifelong diseases. Currently, these diseases are mainly treated with various drugs. According to the routine of diagnosis and treatment, after the acute treatment period, in order to achieve the purpose of consolidating the curative effect and preventing recurrence, it is necessary to maintain the medicine for a long time. Due to diseases, economic conditions, long time course, too much trouble taking medicine and other reasons, the patient's maintenance treatment compliance is poor, and patients often take the initiative to interrupt or do not follow the doctor's advice, causing the disease to recur. Seizu...

Claims

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Application Information

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IPC IPC(8): A61K31/5517A61K9/22A61K9/52A61P25/08A61P25/18A61K31/53
Inventor 郑士全
Owner 郑玉华
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