The invention discloses a medicine for treating Meniere's disease and a preparation method thereof. The medicine is prepared from the following ingredients in parts by mass: 1 part of uncaria, 1 part of rhizoma pinellinae praeparata, 1 part of chrysanthemum, 1 part of poria cocos, 1 part of bamboo shavings, 1 part of atractylodes macrocephala, 1 part of selfheal, 1 part of radix rehmanniae, 1 part of plantain seed, 1 part of radix achyranthis bidentatae, 1 part of Chinese wolfberries, and 1 part of nacre mother of pearl. The preparation method of the medicine comprises the following steps: according to the mass ratio, purchasing clean first-class uncaria, rhizoma pinellinae praeparata, chrysanthemum, poria cocos, bamboo shavings, atractylodes macrocephala, selfheal, radix rehmanniae, plantain seed, radix achyranthis bidentatae, Chinese wolfberries, and nacre mother of pearl, removing the residual impurities respectively, and soaking the materials in cool boiled water for half an hour for standby application; placing the soaked medicinal materials and the clear liquid for soaking the medicinal materials together into an earthenware pot, adding an appropriate amount of cool boiled water, decocting the materials for twice with strong fire first and slow fire later, decocting for the first time for 50 minutes, filtering the medicinal liquid, then adding warm boiled water to perform decoction for the second time for 55 minutes, combining the liquids, and concentrating the combined liquid to obtain 540 ml of traditional Chinese medicinal liquid with a concentration of 50%.