8 results about "Inner Ear Diseases" patented technology

Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid or a pharmaceutically acceptable salt thereof are provided. Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction.

The application discloses an image processing system, method and storage medium, and the method comprises the following steps: acquiring an MRI image of a historical patient's ear and a corresponding medical report; generating left ear and right ear image features according to the MRI image coding; constructing an image reconstruction loss according to the left ear and right ear image features; constructing an image contrast learning loss according to anchor point features extracted from the MRI image; determining a specific severity score according to the medical report, performing cross-modal fusion and alignment between the image and text features extracted from the medical report according to the specific severity score, wherein a cross-modal contrast loss is constructed when the cross-modal alignment is performed; constructing an objective function according to each loss, so as to pre-train a diagnosis model through the objective function; and inputting an MRI image of a current patient's ear and a corresponding medical report into the pre-trained diagnosis model to output a Meniere's disease diagnosis result. The application can realize accurate and efficient diagnosis of Meniere's disease through image processing.

The present invention relates to a novel pyrimidine derivative compound and a use thereof. In auditory cells, the compound has a protective effect through treatment (or alleviation) and prevention of auditory dysfunctions such as ototoxic hearing loss, noise-induced hearing loss, sudden hearing loss, age-related hearing loss, hereditary hearing loss, autoimmune hearing loss, tinnitus, and Meniere's disease, which cause hearing loss by inhibiting homeostasis of auditory organs, and thus can be usefully utilized as a pharmaceutical product.

The invention belongs to the technical field of biological medicine and molecular biology, and particularly relates to application of glutamate enzyme and related biological elements thereof in meniere disease diagnosis and treatment. Specifically, the research finds that IL-1beta increases the glutamic acid level by up-regulating the expression of glutamate enzyme in HEI-OC1 cells. Treatment with a glutaminase inhibitor or an IL-1 [beta] receptor antagonist can alleviate auditory-vestibular dysfunction and reduce glutamic acid levels in endolymphatic hydrops mice. In a word, the research of the invention proves that the neurotransmitter release imbalance and immune response may cause the pathology of the Meniere's disease, possibly explains hearing loss and vertigo related to the Meniere's disease, and provides a new way for treatment intervention.

A system and method for analyzing a sample of earwax for chemical components indicating the presence of an otolaryngological disorder, such as Meniere's Disease. The system includes an analyzer that receives an earwax sample from a person, where the analyzer analyzes the earwax sample and produces diagnostic data. The diagnostic data includes chemical component data for the earwax sample and there is a computer device in communication with analyzer, and the computer device receives the diagnostic data from the analyzer and detects a predetermined combination of chemical components in the earwax sample which will indicate the presence of an otolaryngological disorder.

The application discloses an inner ear diagnosis and treatment robot and a use method. The inner ear diagnosis and treatment robot comprises: a shapeable hose, the outer diameter of the hose is smaller than the inner diameter of a natural cavity, and at least one through operation channel is arranged in the hose; a continuum is arranged in the hose and can be stretched out of the hose from the front end of the hose; a puncture assembly comprises a puncture needle, a liquid storage cavity and a flexible pipeline which are sequentially communicated from the front end to the rear end; a stabilizing device is arranged outside the hose and is used for fixing the hose in the natural cavity, so that the hose does not slide relative to the natural cavity; and a control system is used for controlling the movement of the hose, the continuum and the puncture assembly. The inner ear diagnosis and treatment robot can effectively and accurately realize sampling analysis diagnosis and local drug treatment, and improves the diagnosis and treatment effect of inner ear diseases.

Methods of treating tinnitus, acute sensorineural hearing loss, age-related hearing loss, or Meniere's disease, with a compound according to Formula (I), or a pharmaceutically acceptable salt thereof, are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, or Meniere's disease. Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and ring A have any of the meanings herein defined in the description.

Methods of treating tinnitus, acute sensorineural hearing loss, age-related hearing loss, or Meniere's disease, with a compound according to Formula (I), or a pharmaceutically acceptable salt thereof, are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, or Meniere's disease.or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and ring A have any of the meanings herein defined in the description.