New use of cape jasmine

A use, technology of gardenia, applied in the field of medicine

Inactive Publication Date: 2009-02-11
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no relevant report that gardenia or its c...

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The use of gardenia or geniposide in the preparation of medicines for treating vascular dementia is proved by the following experimental data.

[0016] Materials and Methods

[0017] 1.1 Materials

[0018] Sixty-six healthy male clean two-month-old SD rats, weighing 180±40g, were provided by the West China Medical Experimental Animal Center of Sichuan University. Solid particle beverages were freely ingested and water was freely available. The room temperature was about 22°C, and the photoperiod was 12 / 12h. Donepezil is a product of Eisai Pharmaceutical Co., Ltd., batch number: 070910A. Geniposide, with a purity of 94.8%, batch number: SZY071229, was purchased from Chengdu Dicotyledon Biotechnology Company. The Morris water maze is a product of Beijing Xintiandi Technology Company.

[0019] 1.2 Method

[0020] 1.2.1 Preparation of model: according to references [1] Making rat models of vascular dementia: rats were anesthetized by intraperitoneal injection of chlora...

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PUM

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Abstract

The invention belongs to the medicinal field, in particular to a new application of Gardenia. The technological problem needed to be solved is to provide the new medicinal application of the Gardenia, namely the application in preparing medicines for curing vascular dementia. Proved by experiments, after the inventor adopts a permanent bilateral common carotid artery ligation method and establishes animal models of the vascular dementia and cures the animal models for a month by giving different dosages of geniposide and positive control drug, the inventor carries out behavior and pathological observation for observing the influence of behavior and pathological brain tissue and related biochemical parameters of the geniposide on dementia rats. The inventor finds out that the geniposide with different dosages has functions of improving and recovering cognitive dysfunction of the vascular dementia rats and the rats have dose-dependency, wherein, the geniposide with medium and high dosages has the function of curing the dementia close to donepezil. Therefore, the Gardenia or the geniposide can be adopted for curing the vascular dementia.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of gardenia jasmine. Background technique [0002] Vascular dementia (English name: vascular dementiame abbreviation: VaD) is one of the mental disorders caused by cerebrovascular diseases (such as cerebral infarction or cerebral hemorrhage, etc.), and usually occurs at the age of 50-60. In recent years, the age of onset tends to be middle-aged, with more men than women. The course of disease is as short as 2 months and as long as 20 years, with an average of 5.2 years. Its early manifestations are mainly headache, dizziness, limb numbness, sleep disturbance, tinnitus, etc., and there may be mild impairment of recent memory, inattention and some emotional changes, without obvious dementia, so this manifestation is often called "brain weakness". syndrome". However, with the development of the disease, neuropsychiatric symptoms will appear, such as unclear p...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P9/10A61P25/28
Inventor 周东
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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