Natural high-molecular acrylate and its preparation method

A natural polymer and acrylate technology, which is applied in the field of natural polymer acrylate derivatives and their preparation, can solve the problems of many reaction steps, intense reaction conditions, and poor water solubility of products, and achieve mild conditions and simple operation. Effect

Inactive Publication Date: 2012-03-28
常州市晨光树脂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the disadvantages of these three methods are: although the unsaturated carbon-carbon double bond is introduced, the product has poor water solubility, and the reaction conditions are intense and harsh; although the polymerizable group and the water-soluble gro...

Method used

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  • Natural high-molecular acrylate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] With 2.0g chitosan (DP=90%, Mw=300) with the volume ratio of 200mL be in the solution of triethylamine and chloroform of 1: 1, stir at room temperature and place 48 hours in the ice of 5 ℃ Cool and stir in the bath for 2 hours, dissolve 4.0g of acryloyl chloride in 10mL of chloroform and stir evenly, slowly drop into the chitosan solution in an ice bath and react for 4 hours, continue to react at room temperature for 8 hours, The filtered precipitate was washed three times with acetone to obtain the natural biological material derivative.

[0019] Dissolve 5.0 g of the synthesized natural polymer derivative in 400 mL of phosphate buffer solution with pH=7.4, add 2.02 g of photoinitiator 2-hydroxy-2-methyl-1-p-hydroxyethyl ether phenylacetone , and stir until the solution is uniform. Then inject in the polytetrafluoroethylene template of 8 millimeters (diameter) * 1 millimeter (thickness), after upper and lower two sides are clamped with glass slide glass, leave standst...

Embodiment 2

[0021] With 2.0g chitosan (DP=92%, Mw=3000) with the volume ratio of 300mL is in the solution of diethylamine and dichloromethane of 2: 1, stir at room temperature and place 48 hours in the ice of 8 ℃ Cool and stir in the bath for 2 hours, dissolve 5.0g of methacryloyl chloride in 12.5mL of dichloromethane and stir evenly, slowly add it to the chitosan solution in an ice bath at 1°C to react for 4 hours, and continue at room temperature The reaction was carried out for 8 hours, and the filtered precipitate was washed three times with acetone to obtain the natural biological material derivative.

[0022] Dissolve 5.0 g of the synthesized natural polymer derivative in 400 mL of phosphate buffer solution with pH=7.4, add 2.02 g of photoinitiator 2-hydroxy-2-methyl-1-p-hydroxyethyl ether phenylacetone , and stir until the solution is uniform. Then inject in the polytetrafluoroethylene template of 8 millimeters (diameter) * 1 millimeter (thickness), after upper and lower two sides...

Embodiment 3

[0024] Add 2.0 g of hyaluronic acid (Mw=3000) to 300 mL of a solution of triethylamine and chloroform with a volume ratio of 2:1, stir at room temperature for 48 hours, then cool and stir in an ice bath at 3°C ​​for 2 6.0 g of acryloyl chloride was dissolved in 20 mL of chloroform and stirred evenly, slowly added dropwise to the solution of hyaluronic acid in an ice bath to react for 4 hours, heated to 30°C and reacted for 8 hours, and the precipitate after filtration Wash with acetone three times to obtain the natural biological material derivative.

[0025] Dissolve 5.0 g of the synthesized natural polymer derivative in 400 mL of phosphate buffer solution with pH=7.4, add 2.02 g of photoinitiator 2-hydroxy-2-methyl-1-p-hydroxyethyl ether phenylacetone , and stir until the solution is uniform. Then inject in the polytetrafluoroethylene template of 8 millimeters (diameter) * 1 millimeter (thickness), after upper and lower two sides are clamped with glass slide glass, leave st...

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Abstract

The invention relates to a synthesis method of natural high-molecular acrylate products. The method comprises the steps of: adding a polysaccharide taken from one of chitosan, hyaluronic acid or alpha, beta, gamma-cyclodextrin into a mixed solution of an acid binding agent and chloralkane in a volume ratio of 1-2:1, stirring and placing the mixed solution under room temperature for 48h; cooling and stirring the mixed solution in an ice bath at a temperature of 0-5DEG C for 2h; adding dropwisely a chloralkane solution of 20-40 wt% of unsaturated acyl chloride for 2-4h, controlling the added unsaturated acyl chloride of 2-4 times the weight of the polysaccharide; raising the temperature to 25-30DEG C for a reaction of 8h, and washing the filtered precipitate with acetone for 3 times, thus obtaining a natural biological polysaccharide derivative. The natural biomaterial acrylate product of the method provided in the invention can be used for tissue engineering scaffold materials, drug controlled slow release materials, and UV (ultraviolet)-curing paint materials.

Description

technical field [0001] The invention relates to a natural polymer acrylate derivative and a preparation method thereof, belonging to the field of preparation of natural biological polymer materials. Background technique [0002] Polysaccharide is a kind of natural polymer compound formed by aldose or ketose linked by glycosidic bonds. It is derived from animals, plants and microorganisms. It is an essential substance for organisms to maintain life activities. It is closely related to various physiological functions of life. A variety of biological functions. Such as: immune regulation, anti-infection, anti-tumor, anti-coagulation, hypoglycemic and anti-virus. At present, polysaccharides such as Yunzhi polysaccharide, polyporus polysaccharide, lentinan, schizophyllan, pachyphyllan, heparin, chitosan, etc. It has shown attractive prospects in the treatment of difficult diseases such as [0003] Chitin is widely distributed in nature and mainly exists in crustacean shells, pl...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08B37/16
Inventor 黄天兴吕波陈力
Owner 常州市晨光树脂有限公司
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